GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tlr4 | multiple interactions | EXP | | 6480464 | CTD | Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA] | PMID:27634381 | Tlr4 | decreases expression | ISO | TLR4 (Homo sapiens) | 6480464 | CTD | Quercetin results in decreased expression of TLR4 mRNA; Quercetin results in decreased expression of TLR4 protein | PMID:20828867 PMID:27279714 | Tlr4 | increases expression | ISO | TLR4 (Homo sapiens) | 6480464 | CTD | Quercetin results in increased expression of TLR4 mRNA | PMID:21632981 | Tlr4 | multiple interactions | ISO | TLR4 (Homo sapiens) | 6480464 | CTD | Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [24-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [nickel chloride results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [nickel chloride results in increased expression of TLR4 protein]; Quercetin promotes the reaction [prolinedithiocarbamate results in decreased expression of TLR4 protein]; Quercetin promotes the reaction [TLR4 protein affects the expression of CDH1 protein]; Quercetin promotes the reaction [TLR4 protein affects the expression of MMP2 protein]; Quercetin promotes the reaction [TLR4 protein affects the expression of MMP9 protein]; Quercetin promotes the reaction [TLR4 protein affects the expression of RELA protein]; Quercetin promotes the reaction [TLR4 protein affects the expression of TLR4 protein] | PMID:24802026 PMID:27279714 PMID:30016632 | Tlr4 | multiple interactions | ISO | Tlr4 (Mus musculus) | 6480464 | CTD | Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TLR4 protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]; Quercetin inhibits the reaction [Dietary Fats results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [Palmitic Acid results in increased expression of TLR4 mRNA] | PMID:22915297 PMID:25614714 PMID:26218279 PMID:27601294 | | ||||||||||||||||||||||
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