RGD Reference Report - Expression of toll-like receptor 2 and 4 in intestinal mucosa in experimental severe acute pancreatitis. - Rat Genome Database

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Expression of toll-like receptor 2 and 4 in intestinal mucosa in experimental severe acute pancreatitis.

Authors: Sawa, H  Ueda, T  Takeyama, Y  Yasuda, T  Shinzeki, M  Matsumura, N  Nakajima, T  Kuroda, Y 
Citation: Sawa H, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2247-51.
RGD ID: 2312507
Pubmed: PMID:19260515   (View Abstract at PubMed)

BACKGROUND/AIMS: In severe acute pancreatitis (SAP), endotoxin/bacterial translocation (E/BT) from the gut is main cause of infection, which is contributor to high mortality. Toll-like receptors (TLRs) recognize micro-organisms and are involved in the host defense. This study aimed to investigate the expression of TLR2 and TLR4 in intestinal mucosa in SAP. METHODOLOGY: SAP was induced by injection of 3% sodium deoxycholate into the biliopancreatic duct in rats. Terminal ileum was removed 2, 6, 12, and 18 hours after the induction. Expression of TLR2/4 was analyzed by western blotting and immunohistochemistry. NF-kappaB activation was assessed by enzyme immunoassay. E/BT was also evaluated. RESULTS: TLR2/4 proteins were increased 2 and 6 hours, and were decreased 12 and 18 hours after the induction. Immunoreactivities for them were detected at the top of villi and crypt in control rats. They were increased 6 hours, and were diminished 12 hours after the induction. Activated NF-kappaB was increased 6 hours, and was decreased 18 hours after the induction. E/BT occurred 18 hours after the induction. CONCLUSIONS: Intestinal immune response enhances in the early phase and suppresses in the late phase of SAP, and TLRs may be implicated in the mechanism of E/BT.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pancreatitis  ISOTlr2 (Rattus norvegicus)2312507; 2312507 RGD 
pancreatitis  ISOTlr4 (Rattus norvegicus)2312507; 2312507 RGD 
pancreatitis  IEP 2312507; 2312507 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr2  (toll-like receptor 2)
Tlr4  (toll-like receptor 4)

Genes (Mus musculus)
Tlr2  (toll-like receptor 2)
Tlr4  (toll-like receptor 4)

Genes (Homo sapiens)
TLR2  (toll like receptor 2)
TLR4  (toll like receptor 4)


Additional Information