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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3870
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr4
Name: toll-like receptor 4
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr4increases expressionISOTLR4 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of TLR4 proteinPMID:26187476 PMID:28720485
Tlr4multiple interactionsISOTLR4 (Homo sapiens)6480464CTD[epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TLR4 protein]; gallocatechol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [[Vitallium analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CXCL8 mRNA]; TLR4 protein affects the reaction [[Vitallium analog co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CXCL8 protein]PMID:23680697 PMID:26187476
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