RGD Reference Report - Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis. - Rat Genome Database

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Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.

Authors: Carvalho, A  Pasqualotto, AC  Pitzurra, L  Romani, L  Denning, DW  Rodrigues, F 
Citation: Carvalho A, etal., J Infect Dis. 2008 Feb 15;197(4):618-21.
RGD ID: 5130863
Pubmed: PMID:18275280   (View Abstract at PubMed)
DOI: DOI:10.1086/526500   (Journal Full-text)

Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
allergic bronchopulmonary aspergillosis susceptibilityIAGP 5130863DNA:SNP:promoter:g.-1237T>C (rs5743836) (human)RGD 
allergic bronchopulmonary aspergillosis susceptibilityISOTLR9 (Homo sapiens)5130863; 5130863DNA:SNP:promoter:g.-1237T>C rs5743836 (human)RGD 
invasive aspergillosis susceptibilityIAGP 5130863DNA:polymorphism:exon:p.D299G(human)RGD 
invasive aspergillosis susceptibilityISOTLR4 (Homo sapiens)5130863; 5130863DNA:polymorphism:exon:p.D299G(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr4  (toll-like receptor 4)
Tlr9  (toll-like receptor 9)

Genes (Mus musculus)
Tlr4  (toll-like receptor 4)
Tlr9  (toll-like receptor 9)

Genes (Homo sapiens)
TLR4  (toll like receptor 4)
TLR9  (toll like receptor 9)


Additional Information