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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3870
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr4
Name: toll-like receptor 4
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr4decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of TLR4 mRNAPMID:33387578
Tlr4affects expressionISOTlr4 (Mus musculus)6480464CTDAcetaminophen affects the expression of TLR4 mRNAPMID:17562736
Tlr4increases expressionISOTlr4 (Mus musculus)6480464CTDAcetaminophen results in increased expression of TLR4 proteinPMID:26079055
Tlr4increases response to substanceISOTlr4 (Mus musculus)6480464CTDTLR4 results in increased susceptibility to AcetaminophenPMID:16439473
Tlr4multiple interactionsISOTLR4 (Homo sapiens)6480464CTD[Acetaminophen co-treated with Lipopolysaccharides] results in increased expression of TLR4 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of TLR4 mRNAPMID:31059760 PMID:33819548
Tlr4multiple interactionsISOTlr4 (Mus musculus)6480464CTD[Ethanol co-treated with isopentyl alcohol] promotes the reaction [TLR4 results in increased susceptibility to Acetaminophen]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR4 protein]PMID:16439473 PMID:26079055
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