RGD Reference Report - The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection. - Rat Genome Database

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The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection.

Authors: Jin, X  Lin, Z  Xie, X 
Citation: Jin X, etal., Eur J Clin Microbiol Infect Dis. 2010 Feb;29(2):231-8. doi: 10.1007/s10096-009-0844-z. Epub 2009 Dec 13.
RGD ID: 8552969
Pubmed: PMID:20012880   (View Abstract at PubMed)
DOI: DOI:10.1007/s10096-009-0844-z   (Journal Full-text)

Keratitis caused by Pseudomonas aeruginosa is a potentially vision-threatening condition that requires prompt treatment to prevent vision loss. The recognition of infectious agents by the Toll-like receptor (TLR) system initiates primary innate and later adaptive immune responses. In this study, in late cases of corneal P. aeruginosa infection, the expression of TLR2, 4, 5 and 9 mRNA were all upregulated. In early infection cases, only TLR9 mRNA expression was upregulated. In late cases, the protein expression of TLR2, 4, 5, 9 and pIkappaB-alpha were elevated. In early cases, only TLR9 and pIkappaB-alpha expression were upregulated. Concentrations of IL-6 and IL-8 increased in infected corneas, especially in late cases. Myeloperoxidase (MPO) activity suggested that polymorphonuclear leukocyte (PMN) numbers were higher in late than in early stages of infection. The delayed response of TLRs may explain why P. aeruginosa infection exacerbates rapidly at the early infection stage. This finding may have important implications for the treatment of innate immunologic responses to corneal infections.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Pseudomonas Aeruginosa Keratitis  IEP 8552969; 8552969mRNA and protein:increased expression:cornea:RGD 
Pseudomonas Aeruginosa Keratitis  ISOTLR2 (Homo sapiens)8552969; 8552969mRNA and protein:increased expression:cornea:RGD 
Pseudomonas Aeruginosa Keratitis  ISOTLR4 (Homo sapiens)8552969; 8552969mRNA and protein:increased expression:cornea:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr2  (toll-like receptor 2)
Tlr4  (toll-like receptor 4)

Genes (Mus musculus)
Tlr2  (toll-like receptor 2)
Tlr4  (toll-like receptor 4)

Genes (Homo sapiens)
TLR2  (toll like receptor 2)
TLR4  (toll like receptor 4)


Additional Information