RGD Reference Report - TLR4 and TLR9 are induced in oral lichen planus. - Rat Genome Database

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TLR4 and TLR9 are induced in oral lichen planus.

Authors: Siponen, M  Kauppila, JH  Soini, Y  Salo, T 
Citation: Siponen M, etal., J Oral Pathol Med. 2012 Nov;41(10):741-7. doi: 10.1111/j.1600-0714.2012.01169.x. Epub 2012 Jun 5.
RGD ID: 7777153
Pubmed: PMID:22672741   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1600-0714.2012.01169.x   (Journal Full-text)

BACKGROUND: The role of Toll-like receptors (TLRs) has been elucidated in many human infectious, autoimmune and neoplastic diseases. Previously, TLR2 and TLR4 expression in oral lichen planus (OLP) was described. The aim of our study was to examine expression patterns of TLR4 and TLR9 in normal oral mucosa and OLP and describe the effect of topical tacrolimus treatment on the expression of TLR4 and TLR9 in OLP. METHODS: Toll-like receptor 4 and TLR9 expression was analysed by immunohistochemistry in five samples of normal oral mucosa and 50 samples of OLP (31 representing clinically white and 19 clinically erythematous/erosive lesions). We evaluated also the effect of topical tacrolimus on TLR4 and TLR9 expression in a patient with OLP. RESULTS: Toll-like receptor 4 and TLR9 expression was increased in OLP epithelium compared with normal epithelium (P < 0.001); no significant difference between the two clinical types of OLP was observed. TLR9 expression was strongest in the superficial layer of the epithelium (P < 0.001), while the expression of TLR4 was strongest in the basal layer (P < 0.001). Treatment of OLP lesions with topical tacrolimus resulted in clinical improvement but had no effect on TLR expression levels. CONCLUSIONS: Toll-like receptor 4 and TLR9 are induced in OLP; our finding confirms the results of a previous study. TLR4 and TLR9 may play a part in the pathogenesis of OLP. Further studies are needed to dissect the definitive role of TLRs in OLP pathogenesis and progression and to determine the effect of tacrolimus on the function of TLRs.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Oral Lichen Planus  IEP 7777153; 7777153protein:increased expression:oral epithelium:RGD 
Oral Lichen Planus  ISOTLR4 (Homo sapiens)7777153; 7777153protein:increased expression:oral epithelium:RGD 
Oral Lichen Planus  ISOTLR9 (Homo sapiens)7777153; 7777153protein:increased expression:oral epithelium:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr4  (toll-like receptor 4)
Tlr9  (toll-like receptor 9)

Genes (Mus musculus)
Tlr4  (toll-like receptor 4)
Tlr9  (toll-like receptor 9)

Genes (Homo sapiens)
TLR4  (toll like receptor 4)
TLR9  (toll like receptor 9)


Additional Information