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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3870
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr4
Name: toll-like receptor 4
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr4decreases expressionEXP 6480464CTDSimvastatin results in decreased expression of TLR4 mRNA; Simvastatin results in decreased expression of TLR4 proteinPMID:19166837
Tlr4increases expressionISOTLR4 (Homo sapiens)6480464CTDSimvastatin results in increased expression of TLR4 proteinPMID:16387846
Tlr4multiple interactionsISOTLR4 (Homo sapiens)6480464CTDSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]PMID:16443229
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