GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tlr4 | increases expression | ISO | TLR4 (Homo sapiens) | 6480464 | CTD | nickel chloride results in increased expression of TLR4 mRNA; nickel chloride results in increased expression of TLR4 protein | PMID:30016632 | Tlr4 | increases expression | ISO | Tlr4 (Mus musculus) | 6480464 | CTD | nickel chloride results in increased expression of TLR4 mRNA | PMID:24670797 | Tlr4 | multiple interactions | ISO | TLR4 (Homo sapiens) | 6480464 | CTD | chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased expression of TLR4 mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased expression of TLR4 protein]; nickel chloride results in increased activity of [TLR4 protein binds to LY96 protein]; Quercetin inhibits the reaction [nickel chloride results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [nickel chloride results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [nickel chloride results in increased secretion of CXCL8 protein] | PMID:23692033 PMID:25803856 PMID:30016632 | Tlr4 | multiple interactions | ISO | Tlr4 (Mus musculus) | 6480464 | CTD | TLR4 mutant form inhibits the reaction [nickel chloride results in increased expression of TSLP protein] | PMID:24670797 | | ||||||||||||||||||||||
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