RGD Reference Report - Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain. - Rat Genome Database

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Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain.

Authors: Wu, FX  Bian, JJ  Miao, XR  Huang, SD  Xu, XW  Gong, DJ  Sun, YM  Lu, ZJ  Yu, WF 
Citation: Wu FX, etal., Int J Med Sci. 2010 Aug 2;7(5):251-9.
RGD ID: 4144070
Pubmed: PMID:20714435   (View Abstract at PubMed)
PMCID: PMC2920570   (View Article at PubMed Central)

BACKGROUND: Neuropathic pain is characterized by hyperalgesia, allodynia and spontaneous pain. It often occurs as a result of injury to peripheral nerves, dorsal root ganglions (DRG), spinal cord, or brain. Recent studies have suggested that Toll-like receptor 4 (TLR4) might play a role in neuropathic pain. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we investigated the role of TLR4 in a rat chronic constriction injury (CCI) model and explored the feasibility of treating neuropathic pain by inhibiting TLR4. Our results demonstrated that intrathecal siRNA-mediated suppression of TLR4 attenuated CCI-induced mechanical allodynia and thermal hyperalgesia through inhibiting the activation of NF-kappaB p65 and production of proinflammatory cytokines (e.g., TNF-alpha and IL-1 beta). CONCLUSIONS/SIGNIFICANCE: These findings suggest that suppression of TLR4 mediated by intrathecally administered siRNA may be a new strategy for the treatment of neuropathic pain.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hyperalgesia  ISOTlr4 (Rattus norvegicus)4144070; 4144070 RGD 
Hyperalgesia  IMP 4144070 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr4  (toll-like receptor 4)

Genes (Mus musculus)
Tlr4  (toll-like receptor 4)

Genes (Homo sapiens)
TLR4  (toll like receptor 4)


Additional Information