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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3870
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr4
Name: toll-like receptor 4
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr4increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of TLR4 mRNAPMID:24386269
Tlr4multiple interactionsISOTLR4 (Homo sapiens)6480464CTDcobaltous chloride results in increased activity of [TLR4 protein binds to LY96 protein]; TLR4 protein affects the reaction [cobaltous chloride results in increased secretion of CXCL8 protein]PMID:23692033 PMID:25803856
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