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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3870
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr4
Name: toll-like receptor 4
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr4multiple interactionsISOTLR4 (Homo sapiens)6480464CTD1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [HMGB1 protein binds to LY96 protein binds to TLR4 protein]]; 1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein binds to HMGB1 protein]]; 1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein]]; 1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [NOX4 protein binds to LY96 protein binds to TLR4 protein]]; tert-Butylhydroperoxide promotes the reaction [HMGB1 protein binds to LY96 protein binds to TLR4 protein]; tert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein binds to HMGB1 protein]; tert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein]; tert-Butylhydroperoxide promotes the reaction [NOX4 protein binds to LY96 protein binds to TLR4 protein]PMID:28063877 PMID:29111459
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