GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tlr4 | decreases expression | EXP | | 6480464 | CTD | resveratrol results in decreased expression of TLR4 mRNA; resveratrol results in decreased expression of TLR4 protein | PMID:22246136 PMID:26936125 | Tlr4 | multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TLR4 protein]; resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of TLR4 mRNA]; resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of TLR4 protein] | PMID:27064547 | Tlr4 | affects response to substance | ISO | TLR4 (Homo sapiens) | 6480464 | CTD | TLR4 protein affects the susceptibility to resveratrol | PMID:24758933 | Tlr4 | decreases activity | ISO | TLR4 (Homo sapiens) | 6480464 | CTD | resveratrol results in decreased activity of TLR4 protein | PMID:24758933 | Tlr4 | decreases expression | ISO | TLR4 (Homo sapiens) | 6480464 | CTD | resveratrol results in decreased expression of TLR4; resveratrol results in decreased expression of TLR4 protein | PMID:22251620 PMID:24170104 | Tlr4 | decreases expression | ISO | Tlr4 (Mus musculus) | 6480464 | CTD | resveratrol results in decreased expression of TLR4 protein | PMID:24818579 | Tlr4 | multiple interactions | ISO | TLR4 (Homo sapiens) | 6480464 | CTD | [resveratrol co-treated with [Lipopolysaccharides binds to and results in increased activity of TLR4 protein]] results in decreased secretion of IL10 protein; [resveratrol co-treated with [Lipopolysaccharides binds to and results in increased activity of TLR4 protein]] results in increased secretion of TNF protein; resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; resveratrol promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of TNF mRNA] | PMID:24035785 PMID:26497626 | Tlr4 | multiple interactions | ISO | Tlr4 (Mus musculus) | 6480464 | CTD | dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein]]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of NFKBIA protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of STAT1 protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein] | PMID:22118570 PMID:24756886 PMID:24802390 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |