RGD Reference Report - A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2.

Authors: Genuneit, J  Cantelmo, JL  Weinmayr, G  Wong, GW  Cooper, PJ  Riikjarv, MA  Gotua, M  Kabesch, M  Von Mutius, E  Forastiere, F  Crane, J  Nystad, W  El-Sharif, N  Batlles-Garrido, J  Garcia-Marcos, L  Garcia-Hernandez, G  Morales-Suarez-Varela, M  Nilsson, L  Braback, L  Saraclar, Y  Weiland, SK  Cookson, WO  Strachan, D  Moffatt, MF  Moffatt, M F 
Citation: Genuneit J, etal., Clin Exp Allergy. 2009 Dec;39(12):1875-88.
RGD ID: 5130731
Pubmed: PMID:20085599   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-2222.2009.03364.x   (Journal Full-text)

BACKGROUND: Common polymorphisms have been identified in genes suspected to play a role in asthma. We investigated their associations with wheeze and allergy in a case-control sample from Phase 2 of the International Study of Asthma and Allergies in Childhood. METHODS: We compared 1105 wheezing and 3137 non-wheezing children aged 8-12 years from 17 study centres in 13 countries. Genotyping of 55 candidate single nucleotide polymorphisms (SNPs) in 14 genes was performed using the Sequenom System. Logistic regression models were fitted separately for each centre and each SNP. A combined per allele odds ratio and measures of heterogeneity between centres were derived by random effects meta-analysis. RESULTS: Significant associations with wheeze in the past year were detected in only four genes (IL4R, TLR4, MS4A2, TLR9, P<0.05), with per allele odds ratios generally <1.3. Variants in IL4R and TLR4 were also related to allergen-specific IgE, while polymorphisms in FCER1B (MS4A2) and TLR9 were not. There were also highly significant associations (P<0.001) between SPINK5 variants and visible eczema (but not IgE levels) and between IL13 variants and total IgE. Heterogeneity of effects across centres was rare, despite differences in allele frequencies. CONCLUSIONS: Despite the biological plausibility of IgE-related mechanisms in asthma, very few of the tested candidates showed evidence of association with both wheeze and increased IgE levels. We were unable to confirm associations of the positional candidates DPP10 and PHF11 with wheeze, although our study had ample power to detect the expected associations of IL13 variants with IgE and SPINK5 variants with eczema.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Respiratory Sounds susceptibilityIAGP 5130731DNA:SNPs::rs11536891 more ...RGD 
Respiratory Sounds  IAGP 5130731DNA:SNP:promoter:g.-1486C>T rs187084 (human)RGD 
Respiratory Sounds susceptibilityISOTLR4 (Homo sapiens)5130731; 5130731DNA:SNPs::rs11536891 more ...RGD 
Respiratory Sounds  ISOTLR9 (Homo sapiens)5130731; 5130731DNA:snp:promoter:g.-1486C>T rs187084 (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Abnormal delayed hypersensitivity skin test susceptibilityIAGP 5130731DNA:SNP: :rs11536896(human)RGD 
Increased circulating IgE level susceptibilityIAGP 5130731DNA:SNPs: :rs11536896 more ...RGD 
Objects Annotated

Genes (Rattus norvegicus)
Tlr4  (toll-like receptor 4)
Tlr9  (toll-like receptor 9)

Genes (Mus musculus)
Tlr4  (toll-like receptor 4)
Tlr9  (toll-like receptor 9)

Genes (Homo sapiens)
TLR4  (toll like receptor 4)
TLR9  (toll like receptor 9)


Additional Information