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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:pancreatic ductal carcinoma
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Accession:DOID:3587 term browser browse the term
Definition:A pancreatic carcinoma located_in the pancreatic duct. (DO)
Synonyms:exact_synonym: Duct Cell Carcinoma of the Pancreas;   Pancreas Duct-Cell Carcinoma;   Pancreas Duct-Cell Carcinomas;   Pancreatic Ductal Carcinomas;   ductal carcinoma of the pancreas;   malignant neoplasm of duct of Wirsung;   pancreatic duct cancer;   pancreatic duct cell carcinoma
 primary_id: MESH:D021441
 xref: ICD10CM:C25.3;   ICD9CM:157.3
For additional species annotation, visit the Alliance of Genome Resources.


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pancreatic ductal carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme IEP mRNA, protein:increased expression:pancreas RGD PMID:17481528 RGD:2325211 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ACE2 angiotensin converting enzyme 2 IEP protein:decreased expression:pancreas RGD PMID:19212105 RGD:2325210 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 disease_progression IEP mRNA:increased expression:pancreas RGD PMID:17979891 RGD:2325243 NCBI chr10:133,262,423...133,276,868
Ensembl chr10:133,262,420...133,276,868 		JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 disease_progression IEP protein:altered localization:cytoplasm RGD PMID:14997207 RGD:2325249 NCBI chr 8:38,996,973...39,105,261
Ensembl chr 8:38,996,754...39,105,445 		JBrowse link
G AGR2 anterior gradient 2, protein disulphide isomerase family member IEP mRNA:increased expression:pancreas RGD PMID:19609859 RGD:2325659 NCBI chr 7:16,791,811...16,804,999
Ensembl chr 7:16,791,811...16,833,433 		JBrowse link
G AGTR1 angiotensin II receptor type 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17481528 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G ALB albumin disease_progression IEP RGD PMID:19011933 RGD:2325677 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G ANXA2 annexin A2 disease_progression IEP mRNA, protein:increased expression, altered localization:pancreas, plasma membrane RGD PMID:19260470 PMID:16450333 RGD:2317307, RGD:2325731 NCBI chr15:60,347,151...60,397,986
Ensembl chr15:60,347,134...60,402,883 		JBrowse link
G ANXA5 annexin A5 IEP protein:increased expression:pancreas RGD PMID:19488907 RGD:2317538 NCBI chr 4:121,667,946...121,696,980
Ensembl chr 4:121,667,946...121,696,995 		JBrowse link
G ANXA8 annexin A8 IEP mRNA:increased expression:pancreas RGD PMID:18223320 RGD:2325735 NCBI chr10:47,467,993...47,991,796
Ensembl chr10:47,460,162...47,484,158 		JBrowse link
G APOC1 apolipoprotein C1 IEP RGD PMID:15876873 RGD:2325793 NCBI chr19:44,914,325...44,919,346
Ensembl chr19:44,914,247...44,919,349 		JBrowse link
G ARG2 arginase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23424623 NCBI chr14:67,619,920...67,651,708
Ensembl chr14:67,619,920...67,651,708 		JBrowse link
G BMI1 BMI1 proto-oncogene, polycomb ring finger ISO
IEP		 protein:increased expression:pancreas
protein:increased expression:exocrine pancreas: 		RGD PMID:19585519 PMID:19585519 RGD:9491843, RGD:9491843 NCBI chr10:22,321,099...22,331,484
Ensembl chr10:22,321,099...22,331,484 		JBrowse link
G C19orf33 chromosome 19 open reading frame 33 EXP CTD Direct Evidence: marker/mechanism CTD PMID:35142956 NCBI chr19:38,304,251...38,305,006
Ensembl chr19:38,304,164...38,305,006 		JBrowse link
G CALR calreticulin IEP protein:increased expression:pancreatic duct RGD PMID:15289361 RGD:2326165 NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489 		JBrowse link
G CBX7 chromobox 7 disease_progression IEP protein:decreased expression:pancreas RGD PMID:20185297 RGD:9587360 NCBI chr22:39,130,772...39,152,680
Ensembl chr22:39,120,167...39,152,680 		JBrowse link
G CCKAR cholecystokinin A receptor IEP protein:decreased expression:pancreas
mRNA:increased expression:pancreatic duct		 RGD PMID:12851875 PMID:9239407 RGD:4110816, RGD:4110818 NCBI chr 4:26,481,396...26,490,484
Ensembl chr 4:26,481,396...26,490,484 		JBrowse link
G CCKBR cholecystokinin B receptor IEP protein:decreased expression:pancreas RGD PMID:12851875 RGD:4110816 NCBI chr11:6,259,838...6,272,127
Ensembl chr11:6,259,806...6,272,127 		JBrowse link
G CCND1 cyclin D1 severity IEP protein:increased expression:pancreas (human) RGD PMID:17420962 RGD:13462063 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CD40 CD40 molecule treatment IDA
IMP
IEP		 protein:increased expression:dendritic cell RGD PMID:21436454 PMID:23983255 PMID:20976171 RGD:5490301, RGD:11522743, RGD:5490524 NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863 		JBrowse link
G CDK6 cyclin dependent kinase 6 treatment IDA human cells in a mouse model RGD PMID:24389175 RGD:13782187 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A disease_progression IEP RGD PMID:17671118 RGD:8662851 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A EXP CTD Direct Evidence: marker/mechanism CTD PMID:24986516 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301 		JBrowse link
G CLDN4 claudin 4 IEP RGD PMID:15693851 RGD:2317592 NCBI chr 7:73,830,996...73,832,690
Ensembl chr 7:73,799,542...73,832,690 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr 4:76,033,682...76,036,070
Ensembl chr 4:76,033,682...76,041,415 		JBrowse link
G DNMT1 DNA methyltransferase 1 disease_progression IEP
EXP		 protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:29844410 PMID:19424621 RGD:9588974 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta disease_progression IEP RGD PMID:22919364 RGD:9589121 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359 		JBrowse link
G DTX1 deltex E3 ubiquitin ligase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr12:113,056,730...113,098,025
Ensembl chr12:113,056,730...113,098,028 		JBrowse link
G DTX4 deltex E3 ubiquitin ligase 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr11:59,171,430...59,208,588
Ensembl chr11:59,171,430...59,208,588 		JBrowse link
G EGF epidermal growth factor disease_progression IEP protein:increased expression: : RGD PMID:18505086 RGD:2317644 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766 		JBrowse link
G FASLG Fas ligand IEP
IDA		 protein:increased expression:pancreas, liver RGD PMID:15375495 PMID:10547193 RGD:2317741, RGD:2317747 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FGF2 fibroblast growth factor 2 disease_progression IEP RGD PMID:12717266 PMID:18704599 RGD:2317758, RGD:2317756 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G FSCN1 fascin actin-bundling protein 1 disease_progression IEP protein:increased expression:pancreas RGD PMID:12109856 RGD:2317790 NCBI chr 7:5,592,816...5,606,655
Ensembl chr 7:5,592,816...5,606,655 		JBrowse link
G GPNMB glycoprotein nmb EXP CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr 7:23,246,775...23,275,108
Ensembl chr 7:23,235,967...23,275,108 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 resistance IEP
IAGP
IDA		 mRNA, protein:increased expression:pancreas
DNA:methylation: :		 RGD PMID:12488200 PMID:17265526 PMID:16537562 RGD:2317811, RGD:2317806, RGD:2317809 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G HDAC1 histone deacetylase 1 disease_progression IEP protein:increased expression:pancreas RGD PMID:19424621 RGD:9588974 NCBI chr 1:32,292,083...32,333,626
Ensembl chr 1:32,292,083...32,333,635 		JBrowse link
G HEATR1 HEAT repeat containing 1 treatment IMP RGD PMID:26676747 RGD:10761108 NCBI chr 1:236,549,005...236,604,516
Ensembl chr 1:236,549,005...236,604,516 		JBrowse link
G HES1 hes family bHLH transcription factor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732 		JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 8:79,764,010...79,767,767
Ensembl chr 8:79,762,371...79,767,857 		JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 6:125,749,632...125,761,269
Ensembl chr 6:125,747,664...125,761,269 		JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A EXP CTD Direct Evidence: marker/mechanism CTD PMID:17234771 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946 		JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B EXP CTD Direct Evidence: marker/mechanism CTD PMID:17234771 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254 		JBrowse link
G IGF1 insulin like growth factor 1 ISO RGD PMID:20098680 RGD:2317639 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGF1R insulin like growth factor 1 receptor IEP protein:increased expression:pancreas RGD PMID:14506643 PMID:14627343 RGD:2317652, RGD:2317649 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530 		JBrowse link
G IL4 interleukin 4 IMP RGD PMID:17942922 RGD:2317264 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL4R interleukin 4 receptor IEP protein:increased expression:pancreas RGD PMID:17942922 RGD:2317264 NCBI chr16:27,313,756...27,364,778
Ensembl chr16:27,313,668...27,364,778 		JBrowse link
G INS insulin IEP Glucagon/insulin RGD PMID:19571666 RGD:2317248 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221 		JBrowse link
G JAG1 jagged canonical Notch ligand 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr20:10,637,684...10,673,999
Ensembl chr20:10,637,684...10,673,999 		JBrowse link
G JAG2 jagged canonical Notch ligand 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr14:105,140,995...105,168,776
Ensembl chr14:105,140,982...105,168,824 		JBrowse link
G KDM2B lysine demethylase 2B severity IEP mRNA, protein:increased expression:pancreas (human) RGD PMID:23321669 RGD:9588253 NCBI chr12:121,408,461...121,582,279
Ensembl chr12:121,429,096...121,581,023 		JBrowse link
G KITLG KIT ligand EXP CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr12:88,492,793...88,580,471
Ensembl chr12:88,492,793...88,580,851 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase EXP CTD Direct Evidence: marker/mechanism CTD PMID:25347530 PMID:30654191 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936 		JBrowse link
G KRT7 keratin 7 disease_progression IEP RGD PMID:19260470 RGD:2317307 NCBI chr12:52,233,243...52,255,853
Ensembl chr12:52,232,520...52,252,186 		JBrowse link
G L1CAM L1 cell adhesion molecule severity IEP protein:increased expression:pancreas (human) RGD PMID:20162456 RGD:6483447 NCBI chr  X:153,861,514...153,886,173
Ensembl chr  X:153,861,514...153,886,173 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 EXP CTD Direct Evidence: marker/mechanism CTD PMID:34686948 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 treatment IDA human cells in mouse model RGD PMID:20179210 RGD:14348973 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 IEP mRNA, protein:increased expression:pancreatic duct RGD PMID:15548371 RGD:2317697 NCBI chr 7:100,092,728...100,101,397
Ensembl chr 7:100,092,233...100,101,940 		JBrowse link
G MDM2 MDM2 proto-oncogene severity
onset		 IEP
IAGP		 protein:increased expression:pancreas (human)
DNA:snp:promoter, intron:IVS1+309T>G (human)		 RGD PMID:15810085 PMID:19752772 RGD:2317416, RGD:2317414 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544 		JBrowse link
G MEN1 menin 1 IEP
IDA		 protein:decreased expression:pancreas RGD PMID:19170121 PMID:19170121 RGD:2317294, RGD:2317294 NCBI chr11:64,803,516...64,811,294
Ensembl chr11:64,803,510...64,811,294 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase IEP protein:increased expression:pancreatic duct (human) RGD PMID:7866999 RGD:2317530 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377 		JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase susceptibility IEP
IAGP		 protein:increased activity, increased expression:ductal adenocarcinoma (human)
DNA:missense mutation:cds:p.L84F rs12917 (human)		 RGD PMID:9393761 PMID:16844323 RGD:2317664, RGD:2317648 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983 		JBrowse link
G MIR142 microRNA 142 EXP CTD Direct Evidence: marker/mechanism CTD PMID:29844410 NCBI chr17:58,331,232...58,331,318
Ensembl chr17:58,331,232...58,331,318 		JBrowse link
G MIR873 microRNA 873 EXP CTD Direct Evidence: therapeutic CTD PMID:30654191 NCBI chr 9:28,888,879...28,888,955
Ensembl chr 9:28,888,879...28,888,955 		JBrowse link
G MMP2 matrix metallopeptidase 2 severity IEP protein:increased expression:pancreas RGD PMID:17377415 RGD:2325746 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 IEP protein:increased expression:blood
protein:increased expression:pancreas, serum		 RGD PMID:20332475 PMID:18706098 RGD:2325830, RGD:2325844 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MSLN mesothelin disease_progression IDA
EXP
IEP		 DNA:hypomethylation:5'UTR
CTD Direct Evidence: marker/mechanism
protein:increased secretion:serum		 CTD
RGD		 PMID:14576474 PMID:21775916 PMID:25347530 PMID:12874021 PMID:19818733 RGD:2326065, RGD:2326055 NCBI chr16:760,734...768,865
Ensembl chr16:760,734...768,865 		JBrowse link
G MUC1 mucin 1, cell surface associated disease_progression IEP
IMP
IDA		 protein:increased expression, altered localization:pancreas RGD PMID:14681945 PMID:18713982 PMID:19109152 RGD:2317983, RGD:2324633, RGD:2324616 NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916 		JBrowse link
G MUC3A mucin 3A, cell surface associated disease_progression IEP mRNA:increased expression:pancreas RGD PMID:12657964 RGD:2324946 NCBI chr 7:100,949,534...100,968,347
Ensembl chr 7:100,949,534...100,968,347 		JBrowse link
G MUC4 mucin 4, cell surface associated disease_progression IEP mRNA:increased expression:pancreas
protein:increased expression:pancreas		 RGD PMID:12657964 PMID:16049287 RGD:2324946, RGD:2324942 NCBI chr 3:195,746,771...195,811,929
Ensembl chr 3:195,746,765...195,811,973 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming disease_progression IEP mRNA:increased expression:pancreas RGD PMID:7657125 PMID:10227724 RGD:2324986, RGD:2324907 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138 		JBrowse link
G MUC5B mucin 5B, oligomeric mucus/gel-forming IEP mRNA:increased expression:pancreas RGD PMID:7657125 RGD:2324986 NCBI chr11:1,223,066...1,262,172
Ensembl chr11:1,223,066...1,262,172 		JBrowse link
G NDRG1 N-myc downstream regulated 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16778198 NCBI chr 8:133,237,175...133,297,252
Ensembl chr 8:133,237,175...133,302,022 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21489257 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 IEP protein:increased expression:pancreas (human) RGD PMID:17492507 RGD:5132867 NCBI chr17:51,153,559...51,162,168
Ensembl chr17:51,153,559...51,162,428 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO RGD PMID:12660813 RGD:2325254 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOTCH1 notch receptor 1 ISO
EXP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19208345 PMID:20484026 PMID:19028876 RGD:2325323, RGD:2325324 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048 		JBrowse link
G NOTCH3 notch receptor 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr19:15,159,038...15,200,995
Ensembl chr19:15,159,038...15,200,995 		JBrowse link
G NOTCH4 notch receptor 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 6:32,194,843...32,224,067
Ensembl chr 6:32,194,843...32,224,067 		JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 disease_progression IEP protein:increased expression:pancreas RGD PMID:10209957 PMID:11295066 RGD:2325663, RGD:2325660 NCBI chr15:87,859,751...88,256,739
Ensembl chr15:87,859,751...88,256,791 		JBrowse link
G OSM oncostatin M EXP CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr22:30,262,829...30,266,851
Ensembl chr22:30,262,829...30,266,851 		JBrowse link
G PALLD palladin, cytoskeletal associated protein IEP protein:increased expression, alternative form:pancreas, fibroblast RGD PMID:17404500 RGD:2325781 NCBI chr 4:168,497,052...168,928,441
Ensembl chr 4:168,497,052...168,928,457 		JBrowse link
G PAX6 paired box 6 IEP protein:increased expression:pancreatic duct (human) RGD PMID:17849422 RGD:8552381 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961 		JBrowse link
G PMS1 PMS1 homolog 1, mismatch repair system component IDA protein:increased expression:pancreatic duct RGD PMID:15856462 RGD:2324870 NCBI chr 2:189,784,450...189,877,629
Ensembl chr 2:189,784,085...189,877,629 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma disease_progression IEP RGD PMID:19396032 RGD:2317461 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:18670639 RGD:2317185 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:34686948 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RNF2 ring finger protein 2 IEP protein:increased expression:pancreas RGD PMID:19585519 RGD:9491843 NCBI chr 1:185,045,558...185,102,603
Ensembl chr 1:185,045,497...185,102,603 		JBrowse link
G RXRA retinoid X receptor alpha severity IEP RGD PMID:19396032 RGD:2317461 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585 		JBrowse link
G SERPINA1 serpin family A member 1 IEP mRNA, protein:increased expression:pancreas RGD PMID:12488200 RGD:2317811 NCBI chr14:94,376,747...94,390,635
Ensembl chr14:94,376,747...94,390,693 		JBrowse link
G SLC2A2 solute carrier family 2 member 2 ISO protein:increased expression:pancreatic duct RGD PMID:19252908 RGD:2324975 NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743 		JBrowse link
G SMAD4 SMAD family member 4 disease_progression IEP RGD PMID:15173084 RGD:21066334 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045 		JBrowse link
G SMO smoothened, frizzled class receptor IMP RGD PMID:16826192 RGD:2324981 NCBI chr 7:129,188,633...129,213,545
Ensembl chr 7:129,188,633...129,213,545 		JBrowse link
G STK11 serine/threonine kinase 11 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26887594 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431 		JBrowse link
G TGFB1 transforming growth factor beta 1 disease_progression IEP RGD PMID:16101174 RGD:2325019 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 disease_progression ISO
IEP		 mRNA:increased expresssion:pancreas RGD PMID:17114585 PMID:10547197 RGD:2317498, RGD:2317500 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,478...30,694,249 		JBrowse link
G THBS1 thrombospondin 1 disease_progression IEP
IDA		 DNA:hypermethylation:promoter (human) RGD PMID:12429967 PMID:19065635 RGD:2325025, RGD:2325022 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466 		JBrowse link
G TMPRSS3 transmembrane serine protease 3 IEP RGD PMID:14695172 RGD:2325152 NCBI chr21:42,371,890...42,396,052
Ensembl chr21:42,371,887...42,396,091 		JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29844410 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TSC2 TSC complex subunit 2 severity IEP RGD PMID:16213898 RGD:11568674 NCBI chr16:2,047,985...2,089,491
Ensembl chr16:2,047,967...2,089,491 		JBrowse link
G TYMP thymidine phosphorylase disease_progression IEP RGD PMID:19760965 RGD:2325155 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032 		JBrowse link
G VEGFA vascular endothelial growth factor A EXP CTD Direct Evidence: marker/mechanism CTD PMID:17481528 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VHL von Hippel-Lindau tumor suppressor IDA DNA:hypermethylation:promoter (human) RGD PMID:19065635 RGD:2325022 NCBI chr 3:10,141,778...10,153,667
Ensembl chr 3:10,141,778...10,153,667 		JBrowse link
G YEATS2 YEATS domain containing 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:34686948 NCBI chr 3:183,697,797...183,812,624
Ensembl chr 3:183,697,797...183,812,624 		JBrowse link
G ZZZ3 zinc finger ZZ-type containing 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:34686948 NCBI chr 1:77,562,416...77,683,398
Ensembl chr 1:77,562,416...77,683,419 		JBrowse link
pancreatic adenosquamous carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFB2 transforming growth factor beta 2 ameliorates IMP human cells in a mouse model RGD PMID:21366804 RGD:155630611 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
pancreatic ductal adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member IEP protein:increased expression:pancreas RGD PMID:19714807 RGD:2325658 NCBI chr 7:16,791,811...16,804,999
Ensembl chr 7:16,791,811...16,833,433 		JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 IEP protein:increased expression:pancreas RGD PMID:19077459 RGD:2325696 NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,303,965...19,312,144 		JBrowse link
G CALR calreticulin ameliorates IMP human cells in mouse model
human cells in a mouse model		 RGD PMID:33028359 PMID:29072694 RGD:150520160, RGD:150521706 NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489 		JBrowse link
G CCND1 cyclin D1 severity IAGP
IEP		 DNA:snp:exon:c.870G>A (human)
protein:increased expression:pancreas (human)		 RGD PMID:25470788 PMID:22939953 RGD:13462050, RGD:13462062 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CD59 CD59 molecule (CD59 blood group) disease_progression IEP protein:increased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr11:33,703,010...33,736,479
Ensembl chr11:33,703,010...33,736,479 		JBrowse link
G CDK4 cyclin dependent kinase 4 severity IEP protein:increased expression:pancreas, islet of Langerhans (human) RGD PMID:29735403 RGD:13781899 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013 		JBrowse link
G CFHR3 complement factor H related 3 disease_progression IEP protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 1:196,774,840...196,795,407
Ensembl chr 1:196,774,813...196,795,407 		JBrowse link
G E2F1 E2F transcription factor 1 severity IEP
IAGP		 protein:increased expression:pancreatic ductal cell, nucleus (human)
DNA:amplification: : (human)		 RGD PMID:12650514 PMID:17233815 PMID:27573434 RGD:13838735, RGD:13838739, RGD:13838738 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385 		JBrowse link
G FOXM1 forkhead box M1 disease_progression IEP RGD PMID:24859161 RGD:156430321 NCBI chr12:2,857,680...2,877,174
Ensembl chr12:2,857,680...2,877,174 		JBrowse link
G FUBP1 far upstream element binding protein 1 IEP mRNA:increased expression:pancreatic duct (human) RGD PMID:32481602 RGD:151361197 NCBI chr 1:77,944,055...77,979,501
Ensembl chr 1:77,944,055...77,979,110 		JBrowse link
G GLIPR2 GLI pathogenesis related 2 disease_progression IEP protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 9:36,136,536...36,163,913
Ensembl chr 9:36,136,536...36,163,913 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 treatment IMP human cells in a mouse model RGD PMID:23535601 RGD:13504844 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 disease_progression IEP protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta susceptibility ISO RGD PMID:22264792 RGD:13838741 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G JAK1 Janus kinase 1 IEP mRNA:decreased expression:pancreatic ductal cell (human) RGD PMID:28677798 RGD:13838745 NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 severity
disease_progression		 ISO protein:increased phosphorylation:pancreas (mouse) RGD PMID:28837246 PMID:23237571 RGD:14348974, RGD:14348975 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MIR155 microRNA 155 disease_progression IEP RGD PMID:28198398 RGD:25314300 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G MIR494 microRNA 494 disease_progression
ameliorates		 IEP
IDA		 RGD PMID:24859161 PMID:24859161 RGD:156430321, RGD:156430321 NCBI chr14:101,029,634...101,029,714
Ensembl chr14:101,029,634...101,029,714 		JBrowse link
G PGF placental growth factor severity ISO associated with obesity RGD PMID:26861455 RGD:14349030 NCBI chr14:74,941,830...74,955,764
Ensembl chr14:74,941,834...74,955,626 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IEP mRNA, protein:increased expression:pancreas (human) RGD PMID:20876794 RGD:14390130 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980 		JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 severity IMP human cells in a mouse model RGD PMID:15591514 RGD:14390084 NCBI chr19:18,153,163...18,170,532
Ensembl chr19:18,153,163...18,170,532 		JBrowse link
G PLD1 phospholipase D1 severity IEP protein:increased expression:pancreas (human) RGD PMID:27713167 RGD:14392801 NCBI chr 3:171,600,404...171,810,483
Ensembl chr 3:171,600,404...171,810,950 		JBrowse link
G PTPRB protein tyrosine phosphatase receptor type B disease_progression IEP protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr12:70,515,870...70,637,429
Ensembl chr12:70,515,870...70,637,440 		JBrowse link
G PTPRM protein tyrosine phosphatase receptor type M disease_progression IEP protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr18:7,567,316...8,406,856
Ensembl chr18:7,566,782...8,406,861 		JBrowse link
G RAC1 Rac family small GTPase 1 IEP
ISO		 mRNA:increased expression:pancreas (human)
mRNA, protein:increased expression:pancreas (mouse)		 RGD PMID:23334332 PMID:21684285 RGD:14392806, RGD:14392816 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967 		JBrowse link
G RALA RAS like proto-oncogene A IEP mRNA:increased expression:pancreas (human) RGD PMID:29113235 RGD:14394418 NCBI chr 7:39,623,572...39,708,120
Ensembl chr 7:39,623,565...39,708,120 		JBrowse link
G S100A8 S100 calcium binding protein A8 disease_progression IEP protein:increased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073 		JBrowse link
G SMAD2 SMAD family member 2 severity IEP RGD PMID:26908446 RGD:14394493 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G TGFB1 transforming growth factor beta 1 ameliorates IEP protein:decreased expression:pancreas (human) RGD PMID:8253361 RGD:155630628 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFB2 transforming growth factor beta 2 ameliorates IEP protein:decreased expression:pancreas (human) RGD PMID:8253361 RGD:155630628 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G TGFB3 transforming growth factor beta 3 ameliorates IEP protein:decreased expression:pancreas (human) RGD PMID:8253361 RGD:155630628 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 ameliorates IMP human cell line in a mouse model RGD PMID:17297450 RGD:155630637 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
G VEGFD vascular endothelial growth factor D IEP protein:increased expression:blood serum (human) RGD PMID:21410412 RGD:155630646 NCBI chr  X:15,345,596...15,384,413
Ensembl chr  X:15,345,596...15,384,413 		JBrowse link
G VNN1 vanin 1 disease_progression IEP protein:increased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 6:132,680,849...132,714,055
Ensembl chr 6:132,680,849...132,714,055 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 35773
    disease of cellular proliferation 9921
      Neoplasms by Histologic Type 6606
        Glandular and Epithelial Neoplasms 4775
          carcinoma 3614
            pancreatic carcinoma 194
              pancreatic ductal carcinoma 134
                pancreatic ductal adenocarcinoma + 34
Path 2
Term Annotations click to browse term
  disease 35773
    disease of cellular proliferation 9921
      cancer 6890
        organ system cancer 6644
          endocrine gland cancer 2667
            pancreatic cancer 451
              malignant exocrine pancreas neoplasm 195
                pancreatic carcinoma 194
                  pancreatic ductal carcinoma 134
                    pancreatic ductal adenocarcinoma + 34
paths to the root