Gene: JAK1 (Janus kinase 1) Homo sapiens
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Symbol: JAK1
Name: Janus kinase 1
Description: This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: JAK-1; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); JTK3; OTTHUMP00000010896; tyrosine-protein kinase JAK1
Orthologs:
Mus musculus (house mouse) : Jak1 (Janus kinase 1)  MGI
Rattus norvegicus (Norway rat) : Jak1 (Janus kinase 1)  AGR
Chinchilla lanigera (long-tailed chinchilla) : Jak1 (Janus kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : JAK1 (Janus kinase 1)
Canis lupus familiaris (dog) : JAK1 (Janus kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jak1 (Janus kinase 1)
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Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38164,833,223 - 65,067,746 (-)NCBIGRCh38hg38GRCh38
GRCh37165,298,906 - 65,432,593 (-)NCBIGRCh37hg19GRCh37
Build 36165,071,494 - 65,204,775 (-)NCBINCBI36hg18NCBI36
Build 34165,012,228 - 65,064,007NCBI
Celera163,589,792 - 63,723,086 (-)NCBI
Cytogenetic Map1p31.3NCBImapview
HuRef163,407,815 - 63,541,120 (-)NCBI
CHM1_1165,415,253 - 65,649,730 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

Comparative Map Data
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miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on JAK1
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
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RGD Object Information
RGD ID: 69102
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2017-10-10
Status: ACTIVE