RGD Reference Report - Notch1 Functions as a Tumor Suppressor in a Model of K-ras-Induced Pancreatic Ductal Adenocarcinoma. - Rat Genome Database

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Notch1 Functions as a Tumor Suppressor in a Model of K-ras-Induced Pancreatic Ductal Adenocarcinoma.

Authors: Hanlon, L  Avila, JL  Demarest, RM  Troutman, S  Allen, M  Ratti, F  Rustgi, AK  Stanger, BZ  Radtke, F  Adsay, V  Long, F  Capobianco, AJ  Kissil, JL 
Citation: Hanlon L, etal., Cancer Res. 2010 May 18.
RGD ID: 2325323
Pubmed: PMID:20484026   (View Abstract at PubMed)
PMCID: PMC2880196   (View Article at PubMed Central)
DOI: DOI:10.1158/0008-5472.CAN-09-4645   (Journal Full-text)

K-ras is the most commonly mutated oncogene in pancreatic cancer and its activation in murine models is sufficient to recapitulate the spectrum of lesions seen in human pancreatic ductal adenocarcinoma (PDAC). Recent studies suggest that Notch receptor signaling becomes reactivated in a subset of PDACs, leading to the hypothesis that Notch1 functions as an oncogene in this setting. To determine whether Notch1 is required for K-ras-induced tumorigenesis, we used a mouse model in which an oncogenic allele of K-ras is activated and Notch1 is deleted simultaneously in the pancreas. Unexpectedly, the loss of Notch1 in this model resulted in increased tumor incidence and progression, implying that Notch1 can function as a tumor suppressor gene in PDAC. Cancer Res; 70(11); 4280-6. (c)2010 AACR.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pancreatic ductal carcinoma  ISONotch1 (Mus musculus)2325323; 2325323 RGD 
pancreatic ductal carcinoma  IMP 2325323 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Notch1  (notch receptor 1)

Genes (Mus musculus)
Notch1  (notch 1)

Genes (Homo sapiens)
NOTCH1  (notch receptor 1)


Additional Information