CD59 (CD59 molecule, complement regulatory protein)

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Keyword

Gene: CD59 (CD59 molecule, complement regulatory protein) Homo sapiens

Symbol:

CD59

Name:

CD59 molecule, complement regulatory protein

Description:

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

16.3A5; 1F5; 1F5 antigen; 20 kDa homologous restriction factor; cd59 antigen; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); CD59 glycoprotein; EJ16; EJ30; EL32; FLJ38134; FLJ92039; G344; HRF-20; HRF20; human leukocyte antigen MIC11; Ly-6-like protein; lymphocytic antigen CD59/MEM43; MAC-IP; MACIF; MEM43; MEM43 antigen; membrane attack complex (MAC) inhibition factor; membrane attack complex inhibition factor; membrane inhibitor of reactive lysis; MGC2354; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; OTTHUMP00000232408; OTTHUMP00000232409; OTTHUMP00000232410; OTTHUMP00000232411; OTTHUMP00000232412; OTTHUMP00000232413; OTTHUMP00000232414; OTTHUMP00000232415; OTTHUMP00000232416; OTTHUMP00000232608; OTTHUMP00000232610; p18-20; protectin; surface anitgen recognized by monoclonal antibody 16.3A5; T cell-activating protein

Orthologs:

Mus musculus : Cd59b (CD59b antigen) MGI
Rattus norvegicus : Cd59 (CD59 molecule, complement regulatory protein)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	11	33,653,249 - 33,686,718	-	NCBI
Human Genome Assembly HuRef	11	33,421,201 - 33,454,193	-	NCBI
Human Genome Assembly GRCh37	11	33,724,556 - 33,758,025	-	NCBI
Human Genome Assembly Build 36	11	33,681,132 - 33,714,600	-	NCBI
Human Cytogenetic Map	11	p13		NCBI
Human Genome Assembly	11	33,681,133 - 33,714,600		NCBI