RGD Reference Report - Increased expression of alpha-1-antitrypsin, glutathione S-transferase pi and vascular endothelial growth factor in human pancreatic adenocarcinoma. - Rat Genome Database

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Increased expression of alpha-1-antitrypsin, glutathione S-transferase pi and vascular endothelial growth factor in human pancreatic adenocarcinoma.

Authors: Trachte, AL  Suthers, SE  Lerner, MR  Hanas, JS  Jupe, ER  Sienko, AE  Adesina, AM  Lightfoot, SA  Brackett, DJ  Postier, RG 
Citation: Trachte AL, etal., Am J Surg. 2002 Dec;184(6):642-7; discussion 647-8.
RGD ID: 2317811
Pubmed: PMID:12488200   (View Abstract at PubMed)

BACKGROUND: This study was designed to investigate abnormalities in gene expression in ductal adenocarcinoma of the pancreas using cDNA arrays. METHODS: Gene expression in pancreatic ductal adenocarcinoma was compared with normal pancreatic tissue controls. Specimens from 5 patients with pancreatic adenocarcinoma were taken fresh at operation and analyzed using commercially prepared cDNA arrays evaluating approximately 2,000 genes. Immunohistochemical staining was used to confirm protein expression of selected genes. RESULTS: Alpha-1-antitrypsin (A1AT) and glutathione S-transferase pi (GSTP) were significantly up-regulated in all 5 tumors. Vascular endothelial growth factor (VEGF) was up-regulated in 4 of the 5 patients. Immunohistochemical staining verified the overexpression of each of these genes. CONCLUSIONS: A1AT, GSTP, and VEGF are overexpressed in human pancreatic adenocarcinoma specimens taken fresh at operation. To our knowledge, this is the first study of human pancreatic ductal adenocarcinoma demonstrating the up-regulation of these genes using gene expression arrays.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pancreatic ductal carcinoma  IEP 2317811; 2317811mRNA and protein:increased expression:pancreasRGD 
pancreatic ductal carcinoma  ISOGSTP1 (Homo sapiens)2317811; 2317811mRNA and protein:increased expression:pancreasRGD 
pancreatic ductal carcinoma  ISOSERPINA1 (Homo sapiens)2317811; 2317811mRNA and protein:increased expression:pancreasRGD 

Objects Annotated

Genes (Rattus norvegicus)
Gstp1  (glutathione S-transferase pi 1)
Serpina1  (serpin family A member 1)

Genes (Mus musculus)
Gstp1  (glutathione S-transferase, pi 1)
Serpina1e  (serine (or cysteine) peptidase inhibitor, clade A, member 1E)

Genes (Homo sapiens)
GSTP1  (glutathione S-transferase pi 1)
SERPINA1  (serpin family A member 1)


Additional Information