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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1550266 | 6480464 | Ethinyl Estradiol results in increased expression of PGF mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1550266 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PGF mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:1550266 | 6480464 | Ethinyl Estradiol affects the expression of PGF mRNA | CTD | PMID:17555576 | 17beta-estradiol | affects expression | ISO | RGD:1550266 | 6480464 | Estradiol affects the expression of PGF mRNA | CTD | PMID:15598610 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PGF mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PGF mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1550266 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PGF mRNA | CTD | PMID:17942748 | 2,3-dimethoxynaphthalene-1,4-dione | decreases expression | EXP | | 6480464 | 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of PGF mRNA | CTD | PMID:17547211 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:1550266 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of PGF mRNA | CTD | PMID:18648102 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of PGF mRNA | CTD | PMID:21632981 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of PGF mRNA | CTD | PMID:21934132 | ammonium chloride | affects expression | ISO | RGD:619850 | 6480464 | Ammonium Chloride affects the expression of PGF mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of PGF mRNA | CTD | PMID:20106945 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of PGF mRNA | CTD | PMID:20106945 PMID:21632981 | cadmium dichloride | affects expression | EXP | | 6480464 | Cadmium Chloride affects the expression of PGF mRNA | CTD | PMID:20580663 | choline | multiple interactions | ISO | RGD:1550266 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PGF gene | CTD | PMID:20938992 | chromium atom | decreases expression | EXP | | 6480464 | Chromium results in decreased expression of PGF mRNA | CTD | PMID:17547211 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of PGF mRNA | CTD | PMID:17553155 | cocaine | affects expression | ISO | RGD:619850 | 6480464 | Cocaine affects the expression of PGF mRNA | CTD | PMID:20187946 | coumestrol | decreases expression | EXP | | 6480464 | Coumestrol results in decreased expression of PGF mRNA | CTD | PMID:19167446 | dextran sulfate | decreases expression | ISO | RGD:619850 | 6480464 | Dextran Sulfate results in decreased expression of PGF mRNA | CTD | PMID:16375993 | dextran sulfate | multiple interactions | ISO | RGD:619850 | 6480464 | Oligosaccharides inhibits the reaction [Dextran Sulfate results in decreased expression of PGF mRNA] | CTD | PMID:16375993 | diarsenic trioxide | decreases expression | EXP | | 6480464 | arsenic trioxide results in decreased expression of PGF mRNA | CTD | PMID:17547211 | dibutyl phthalate | increases expression | ISO | RGD:1550266 | 6480464 | Dibutyl Phthalate results in increased expression of PGF mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | ISO | RGD:1550266 | 6480464 | Dibutyl Phthalate results in increased expression of PGF mRNA | CTD | PMID:17361019 PMID:21266533 | dibutyl phthalate | decreases expression | ISO | RGD:619850 | 6480464 | Dibutyl Phthalate results in decreased expression of PGF mRNA | CTD | PMID:21266533 | dioxygen | multiple interactions | ISO | RGD:1550266 | 6480464 | HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of PGF mRNA] | CTD | PMID:20880076 | dioxygen | increases expression | ISO | RGD:1550266 | 6480464 | Oxygen deficiency results in increased expression of PGF mRNA | CTD | PMID:20880076 | folic acid | multiple interactions | ISO | RGD:1550266 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PGF gene | CTD | PMID:20938992 | furosemide | decreases expression | ISO | RGD:619850 | 6480464 | Furosemide results in decreased expression of PGF mRNA | CTD | PMID:16526316 | L-methionine | multiple interactions | ISO | RGD:1550266 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PGF gene | CTD | PMID:20938992 | manganese atom | increases expression | EXP | | 6480464 | Manganese results in increased expression of PGF mRNA | CTD | PMID:17175027 | manganese(0) | increases expression | EXP | | 6480464 | Manganese results in increased expression of PGF mRNA | CTD | PMID:17175027 | manganese(II) chloride | increases expression | EXP | | 6480464 | manganese chloride results in increased expression of PGF mRNA | CTD | PMID:17175027 | N-nitrosodimethylamine | decreases expression | EXP | | 6480464 | Dimethylnitrosamine results in decreased expression of PGF mRNA | CTD | PMID:17547211 | naphthalene | increases expression | ISO | RGD:1550266 | 6480464 | naphthalene results in increased expression of PGF mRNA | CTD | PMID:18978301 | nickel sulfate | increases expression | EXP | | 6480464 | nickel sulfate results in increased expression of PGF mRNA | CTD | PMID:18832182 | nickel sulfate | increases expression | EXP | | 6480464 | nickel sulfate results in increased expression of PGF mRNA | CTD | PMID:18651567 PMID:18832182 | nickel sulfate | multiple interactions | EXP | | 6480464 | [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of PGF mRNA | CTD | PMID:18832182 | oxaliplatin | increases expression | EXP | | 6480464 | oxaliplatin results in increased expression of PGF protein | CTD | PMID:18790786 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PGF mRNA | CTD | PMID:22230336 | paraquat | increases expression | ISO | RGD:619850 | 6480464 | Paraquat results in increased expression of PGF mRNA; more ... | CTD | PMID:17997886 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PGF mRNA | CTD | PMID:19710929 | potassium dichromate | decreases expression | EXP | | 6480464 | Potassium Dichromate results in decreased expression of PGF mRNA | CTD | PMID:17547211 | tamoxifen | affects expression | ISO | RGD:1550266 | 6480464 | Tamoxifen affects the expression of PGF mRNA | CTD | PMID:17555576 | thimerosal | increases expression | EXP | | 6480464 | Thimerosal results in increased expression of PGF mRNA | CTD | PMID:16870260 | zinc atom | increases expression | EXP | | 6480464 | Zinc results in increased expression of PGF mRNA | CTD | PMID:16870260 | zinc atom | multiple interactions | EXP | | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of PGF mRNA | CTD | PMID:18593933 | zinc dichloride | increases expression | EXP | | 6480464 | zinc chloride results in increased expression of PGF mRNA | CTD | PMID:16870260 | zinc(0) | increases expression | EXP | | 6480464 | Zinc results in increased expression of PGF mRNA | CTD | PMID:16870260 | zinc(0) | multiple interactions | EXP | | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of PGF mRNA | CTD | PMID:18593933 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Focal adhesion |
| Pathways in cancer | |
| PI3K-Akt signaling pathway | |
| Pathway Interaction Database | VEGFR1 specific signals (PID:200177) |
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Focal adhesion |
| Pathways in cancer | |
| PI3K-Akt signaling pathway | |
| Pathway Interaction Database | VEGFR1 specific signals (PID:200177) |
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RGD Disease Portals| PGF has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| PGF (Homo sapiens) |
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| Pgf (Mus musculus) |
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| Pgf (Rattus norvegicus) |
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Position Markers| G10734 |
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| RH70005 |
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| PGF_2125 |
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| RH70836 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NG_029168 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001207012 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_002632 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | A18411 | (Get FASTA) | Search GEO for Microarray Profiles |
| ABBA01030712 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC006530 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK309886 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK310608 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK310886 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01005857 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC001422 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC007255 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC007789 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BT007182 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BX248289 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BX356823 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471061 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CQ858316 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CS067234 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CS172367 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CS367406 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU332861 | (Get FASTA) | Search GEO for Microarray Profiles | |
| HC040687 | (Get FASTA) | Search GEO for Microarray Profiles | |
| JX512453 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S57152 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S72960 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X54936 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001207012 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001193941 | ||||||||||||||||||||
| Peptide Label: | isoform 2 precursor | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_002632 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_002623 | |||||||||||||||||||||||||
| Peptide Label: | isoform 1 precursor | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001193941 | (Get FASTA) |
| NP_002623 | (Get FASTA) | |
| GenBank Protein | AAB25832 | (Get FASTA) |
| AAB30462 | (Get FASTA) | |
| AAD30179 | (Get FASTA) | |
| AAH01422 | (Get FASTA) | |
| AAH07255 | (Get FASTA) | |
| AAH07789 | (Get FASTA) | |
| AAP35846 | (Get FASTA) | |
| ABM83062 | (Get FASTA) | |
| ABM86256 | (Get FASTA) | |
| ABY87550 | (Get FASTA) | |
| AGC09600 | (Get FASTA) | |
| CAA01393 | (Get FASTA) | |
| CAA38698 | (Get FASTA) | |
| CAD62617 | (Get FASTA) | |
| CAH23419 | (Get FASTA) | |
| CAI84580 | (Get FASTA) | |
| CAJ32891 | (Get FASTA) | |
| CAL32761 | (Get FASTA) | |
| CBH30536 | (Get FASTA) | |
| EAW81207 | (Get FASTA) | |
| EAW81208 | (Get FASTA) | |
| EAW81209 | (Get FASTA) | |
| P49763 | (Get FASTA) |
Promoters| RGD ID: | 6866626 | ||||||||||
| Promoter ID: | EPDNEW_H6478 | ||||||||||
| Type: | initiation region | ||||||||||
| Name: | GRSF1_1 | ||||||||||
| Description: | G-rich RNA sequence binding factor 1 | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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| RGD ID: | 6791796 | ||||||||||
| Promoter ID: | HG_KWN:19803 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | K562, Lymphoblastoid | ||||||||||
| Transcripts: | ENST00000405431, NM_002632, UC001XRA.1, UC001XRB.1, UC010ASE.1, UC010ASF.1 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| COSMIC | PGF | COSMIC |
| Ensembl Genes | ENSG00000119630 | ENTREZGENE |
| Ensembl Protein | ENSP00000451040 | ENTREZGENE |
| ENSP00000451413 | ENTREZGENE | |
| Ensembl Transcript | ENST00000553716 | ENTREZGENE |
| ENST00000555567 | ENTREZGENE | |
| Entrez Gene | 5228 | ENTREZGENE |
| Germonline | ENSG00000119630 | |
| HGNC ID | 8893 | ENTREZGENE |
| HomoloGene Group ID | 1978 | ENTREZGENE |
| HPRD ID | 03076 | ENTREZGENE |
| InterPro | PD_growth_factor | UniProtKB/Swiss-Prot |
| PD_growth_factor_CS | UniProtKB/Swiss-Prot | |
| KEGG Report | hsa:5228 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 601121 | OMIM |
| Pfam | PDGF | UniProtKB/Swiss-Prot |
| PharmGKB | PA33231 | PharmGKB |
| PROSITE | PDGF_1 | UniProtKB/Swiss-Prot |
| PDGF_2 | UniProtKB/Swiss-Prot | |
| SMART | PDGF | UniProtKB/Swiss-Prot |
| UniGene | Hs.252820 | ENTREZGENE |
| UniProt | G3XA84_HUMAN | UniProtKB/TrEMBL |
| PLGF_HUMAN | UniProtKB/Swiss-Prot | |
| Q53XY6_HUMAN | UniProtKB/TrEMBL | |
| Q86TW6_HUMAN | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-08-16 | PGF | placental growth factor | PGF | placental growth factor | Symbol and/or name change | 39860 | APPROVED |
| 2011-07-27 | PGF | placental growth factor | PGF | placental growth factor | Symbol and/or name change | 39860 | APPROVED |
| More on PGF | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 1347328 |
| Created: | 2005-03-08 |
| Species: | Homo sapiens |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




