RGD Reference Report - Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer.

Authors: Di Renzo, MF  Poulsom, R  Olivero, M  Comoglio, PM  Lemoine, NR 
Citation: Di Renzo MF, etal., Cancer Res. 1995 Mar 1;55(5):1129-38.
RGD ID: 2317530
Pubmed: PMID:7866999   (View Abstract at PubMed)

The c-MET oncogene encodes the receptor for hepatocyte growth factor (HGF) scatter factor, a multifunctional cytokine able to mediate morphogenesis as well as invasive growth of epithelial cells. The c-MET-encoded receptor is detectable only at low levels in the normal human exocrine pancreas, but it is up-regulated in the majority of pancreatic ductal adenocarcinomas. The c-MET-encoded HGF receptor is also overexpressed in a proportion of the panel of 31 human pancreatic cancer cell lines examined, which have a range of different growth properties and degrees of differentiation. In most cases the HGF receptor found in the malignant cells has features of the normal receptor. When added to pancreatic cancer cell lines, HGF triggers receptor phosphorylation and stimulates cells to move and proliferate. In overexpressing cell lines, the Met/HGF receptor is phosphorylated in the absence of endogenously produced or exogenously added ligand. These data suggest that the Met/HGF receptor may be involved in the growth and behavior of pancreatic cancer and may contribute to the ductal phenotype of these tumors.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pancreatic ductal carcinoma  IEP 2317530protein:increased expression:pancreatic duct (human)RGD 
pancreatic ductal carcinoma  ISOMET (Homo sapiens)2317530; 2317530protein:increased expression:pancreatic duct (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Met  (MET proto-oncogene, receptor tyrosine kinase)

Genes (Mus musculus)
Met  (met proto-oncogene)

Genes (Homo sapiens)
MET  (MET proto-oncogene, receptor tyrosine kinase)


Additional Information