RGD Reference Report - Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma. - Rat Genome Database

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Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma.

Authors: Sakamoto, Y  Kitajima, Y  Edakuni, G  Sasatomi, E  Mori, M  Kitahara, K  Miyazaki, K 
Citation: Sakamoto Y, etal., Oncol Rep. 2001 May-Jun;8(3):477-84.
RGD ID: 2325660
Pubmed: PMID:11295066   (View Abstract at PubMed)

Pancreatic ductal adenocarcinoma (PDAC) is a widely known severe malignancy with a poor prognosis. Perineural invasion extending to the extra-pancreatic nerve plexus, a significant concern in the treatment is frequently present in this cancer. We analyzed immunohistochemical expression of neurotrophins (NGF, BDNF, NT-3) and the cognate receptors, Trk tyrosine kinase receptor family (TrkA, B, C) and p75NGFR in 28 surgically resected PDAC specimens. A comparative study between several clinicopathologic factors and Trk receptors revealed a significant correlation between increased expression of TrkA and cancer proliferation, as well as TrkC and cancer invasion, including venous and perineural invasion. The present findings revealed a novel mechanism in PDAC progression that is mediated via a NTs-Trk interaction.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pancreatic ductal carcinoma disease_progressionIEP 2325660 RGD 
pancreatic ductal carcinoma disease_progressionISONTRK3 (Homo sapiens)2325660; 2325660 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ntrk3  (neurotrophic receptor tyrosine kinase 3)

Genes (Mus musculus)
Ntrk3  (neurotrophic tyrosine kinase, receptor, type 3)

Genes (Homo sapiens)
NTRK3  (neurotrophic receptor tyrosine kinase 3)


Additional Information