Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | ZZZ3 | Human | 1,2-dimethylhydrazine | decreases expression | ISO | Zzz3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of ZZZ3 mRNA | CTD | PMID:22206623 | ZZZ3 | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Zzz3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of ZZZ3 mRNA | CTD | PMID:21570461 | ZZZ3 | Human | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of ZZZ3 mRNA | CTD | PMID:29704546 | ZZZ3 | Human | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Zzz3 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of ZZZ3 mRNA | CTD | PMID:20188158 | ZZZ3 | Human | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Zzz3 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ZZZ3 mRNA | CTD | PMID:26251327 | ZZZ3 | Human | aflatoxin B1 | increases expression | ISO | Zzz3 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of ZZZ3 mRNA | CTD | PMID:19770486 | ZZZ3 | Human | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of ZZZ3 intron | CTD | PMID:30157460 | ZZZ3 | Human | aflatoxin B1 | decreases methylation | EXP | | 6480464 | Aflatoxin B1 results in decreased methylation of ZZZ3 gene | CTD | PMID:27153756 | ZZZ3 | Human | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of ZZZ3 mRNA | CTD | PMID:33167477 | ZZZ3 | Human | amosite asbestos | increases methylation | EXP | | 6480464 | Asbestos and Amosite results in increased methylation of ZZZ3 promoter | CTD | PMID:29626692 | ZZZ3 | Human | aristolochic acid A | decreases expression | EXP | | 6480464 | aristolochic acid I results in decreased expression of ZZZ3 mRNA | CTD | PMID:33212167 | ZZZ3 | Human | arsenite(3-) | multiple interactions | EXP | | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to ZZZ3 mRNA] | CTD | PMID:32406909 | ZZZ3 | Human | arsenous acid | increases expression | EXP | | 6480464 | Arsenic Trioxide results in increased expression of ZZZ3 mRNA | CTD | PMID:19128835 | ZZZ3 | Human | benzo[a]pyrene | multiple interactions | ISO | Zzz3 (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to ZZZ3 promoter] | CTD | PMID:19654925 | ZZZ3 | Human | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of ZZZ3 intron | CTD | PMID:30157460 | ZZZ3 | Human | benzo[a]pyrene diol epoxide I | decreases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:19150397 | ZZZ3 | Human | benzo[e]pyrene | increases methylation | EXP | | 6480464 | benzo(e)pyrene results in increased methylation of ZZZ3 intron | CTD | PMID:30157460 | ZZZ3 | Human | bisphenol A | decreases expression | ISO | Zzz3 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of ZZZ3 mRNA | CTD | PMID:25181051 | ZZZ3 | Human | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of ZZZ3 gene | CTD | PMID:31601247 | ZZZ3 | Human | bisphenol A | decreases methylation | ISO | Zzz3 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of ZZZ3 promoter | CTD | PMID:27312807 | ZZZ3 | Human | bisphenol A | increases methylation | ISO | Zzz3 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of ZZZ3 gene | CTD | PMID:28505145 | ZZZ3 | Human | carbon nanotube | decreases expression | ISO | Zzz3 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | ZZZ3 | Human | carbon nanotube | affects expression | ISO | Zzz3 (Mus musculus) | 6480464 | Nanotubes and Carbon affects the expression of ZZZ3 mRNA | CTD | PMID:31978390 | ZZZ3 | Human | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ZZZ3 gene] | CTD | PMID:28238834 | ZZZ3 | Human | chlorpyrifos | decreases expression | ISO | Zzz3 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of ZZZ3 mRNA | CTD | PMID:37019170 | ZZZ3 | Human | copper(II) sulfate | decreases expression | EXP | | 6480464 | Copper Sulfate results in decreased expression of ZZZ3 mRNA | CTD | PMID:19549813 | ZZZ3 | Human | coumarin | decreases phosphorylation | EXP | | 6480464 | coumarin results in decreased phosphorylation of ZZZ3 protein | CTD | PMID:35688186 | ZZZ3 | Human | cyclosporin A | increases expression | EXP | | 6480464 | Cyclosporine results in increased expression of ZZZ3 mRNA | CTD | PMID:20106945 and PMID:25562108 | ZZZ3 | Human | diarsenic trioxide | increases expression | EXP | | 6480464 | Arsenic Trioxide results in increased expression of ZZZ3 mRNA | CTD | PMID:19128835 | ZZZ3 | Human | dicrotophos | decreases expression | EXP | | 6480464 | dicrotophos results in decreased expression of ZZZ3 mRNA | CTD | PMID:28302478 | ZZZ3 | Human | disodium selenite | increases expression | EXP | | 6480464 | Sodium Selenite results in increased expression of ZZZ3 mRNA | CTD | PMID:18175754 | ZZZ3 | Human | doxorubicin | affects expression | EXP | | 6480464 | Doxorubicin affects the expression of ZZZ3 mRNA | CTD | PMID:29803840 | ZZZ3 | Human | enzyme inhibitor | multiple interactions | EXP | | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ZZZ3 protein | CTD | PMID:23301498 | ZZZ3 | Human | FR900359 | affects phosphorylation | EXP | | 6480464 | FR900359 affects the phosphorylation of ZZZ3 protein | CTD | PMID:37730182 | ZZZ3 | Human | geraniol | increases expression | EXP | | 6480464 | geraniol results in increased expression of ZZZ3 mRNA | CTD | PMID:27683099 | ZZZ3 | Human | methapyrilene | increases methylation | EXP | | 6480464 | Methapyrilene results in increased methylation of ZZZ3 intron | CTD | PMID:30157460 | ZZZ3 | Human | methimazole | decreases expression | ISO | Zzz3 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of ZZZ3 mRNA | CTD | PMID:30047161 | ZZZ3 | Human | N-nitrosodiethylamine | increases expression | ISO | Zzz3 (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of ZZZ3 mRNA | CTD | PMID:17942915 | ZZZ3 | Human | N-nitrosodiethylamine | multiple interactions | ISO | Zzz3 (Mus musculus) | 6480464 | MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ZZZ3 mRNA] | CTD | PMID:17942915 | ZZZ3 | Human | ochratoxin A | decreases acetylation | EXP | | 6480464 | ochratoxin A results in decreased acetylation of ZZZ3 promoter | CTD | PMID:29098329 | ZZZ3 | Human | ochratoxin A | decreases expression | EXP | | 6480464 | ochratoxin A results in decreased expression of ZZZ3 mRNA | CTD | PMID:29098329 | ZZZ3 | Human | ochratoxin A | multiple interactions | EXP | | 6480464 | [ochratoxin A results in decreased acetylation of ZZZ3 promoter] which results in decreased expression of ZZZ3 mRNA | CTD | PMID:29098329 | ZZZ3 | Human | oxaliplatin | multiple interactions | ISO | Zzz3 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of ZZZ3 mRNA | CTD | PMID:25729387 | ZZZ3 | Human | paracetamol | affects expression | ISO | Zzz3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of ZZZ3 mRNA | CTD | PMID:17562736 | ZZZ3 | Human | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of ZZZ3 mRNA | CTD | PMID:19159669 | ZZZ3 | Human | sulfadimethoxine | decreases expression | ISO | Zzz3 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in decreased expression of ZZZ3 mRNA | CTD | PMID:30047161 | ZZZ3 | Human | sunitinib | increases expression | EXP | | 6480464 | Sunitinib results in increased expression of ZZZ3 mRNA | CTD | PMID:31533062 | ZZZ3 | Human | tetrachloromethane | increases expression | ISO | Zzz3 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of ZZZ3 mRNA | CTD | PMID:27339419 and PMID:31919559 | ZZZ3 | Human | thapsigargin | decreases expression | ISO | Zzz3 (Mus musculus) | 6480464 | Thapsigargin results in decreased expression of ZZZ3 protein | CTD | PMID:24648495 | ZZZ3 | Human | thioacetamide | increases expression | ISO | Zzz3 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of ZZZ3 mRNA | CTD | PMID:23411599 | ZZZ3 | Human | topotecan | decreases expression | ISO | Zzz3 (Rattus norvegicus) | 6480464 | Topotecan results in decreased expression of ZZZ3 mRNA | CTD | PMID:25729387 | ZZZ3 | Human | topotecan | multiple interactions | ISO | Zzz3 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of ZZZ3 mRNA | CTD | PMID:25729387 | ZZZ3 | Human | triptonide | affects expression | ISO | Zzz3 (Mus musculus) | 6480464 | triptonide affects the expression of ZZZ3 mRNA | CTD | PMID:33045310 | ZZZ3 | Human | tungsten | decreases expression | ISO | Zzz3 (Mus musculus) | 6480464 | Tungsten results in decreased expression of ZZZ3 mRNA | CTD | PMID:30912803 | ZZZ3 | Human | valproic acid | decreases methylation | EXP | | 6480464 | Valproic Acid results in decreased methylation of ZZZ3 gene | CTD | PMID:29154799 | ZZZ3 | Human | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of ZZZ3 mRNA | CTD | PMID:25979313 | ZZZ3 | Human | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of ZZZ3 mRNA | CTD | PMID:23179753 and PMID:27188386 | |