Gene: SERPINA1 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1)  Homo sapiens
Symbol: SERPINA1
Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Description: The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A1A; A1AT; AAT; alpha-1 protease inhibitor; alpha-1-antiproteinase; alpha-1-antitrypsin; alpha-1-antitrypsin null; alpha1AT; MGC23330; MGC9222; OTTHUMP00000197150; OTTHUMP00000197151; OTTHUMP00000197152; OTTHUMP00000197153; OTTHUMP00000197154; OTTHUMP00000245864; PI; PI1; PRO2275; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; serine (or cysteine) proteinase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; serpin A1
Orthologs: Rattus norvegicus : Serpina1 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1)
Related Pseudogenes: SERPINA2P  
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_11475,833,958 - 75,847,903-NCBI
Human Genome Assembly HuRef1475,022,652 - 75,036,601-NCBI
Human Genome Assembly GRCh371494,843,084 - 94,857,029-NCBI
Human Genome Assembly Build 361493,914,451 - 93,926,782-NCBI
Human Cytogenetic Map14q32.1 NCBI
Human Genome Assembly1493,914,450 - 93,926,782 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation    (Toggle Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
  
More on SERPINA1
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 1349357
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2013-05-14
Status: ACTIVE



Contact Us |  About Us |  Jobs at RGD