CDK4 (cyclin-dependent kinase 4) - Rat Genome Database

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Keyword

Gene: CDK4 (cyclin-dependent kinase 4) Homo sapiens

Symbol:

CDK4

Name:

cyclin-dependent kinase 4

Description:

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

cell division kinase 4; cell division protein kinase 4; CMM3; cyclin-dependent kinase 4; melanoma cutaneous malignant, 3; MGC14458; OTTHUMP00000243624; OTTHUMP00000243627; OTTHUMP00000243628; PSK-J3

Orthologs:

Mus musculus : Cdk4 (cyclin-dependent kinase 4) MGI
Rattus norvegicus : Cdk4 (cyclin-dependent kinase 4)

Related Pseudogenes:

CDK4PS

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	12	57,975,948 - 57,980,668	-	NCBI
Human Genome Assembly HuRef	12	55,178,350 - 55,183,070	-	NCBI
Human Genome Assembly GRCh37	12	58,141,510 - 58,146,230	-	NCBI
Human Genome Assembly Build 36	12	56,428,270 - 56,432,431	-	NCBI
Human Cytogenetic Map	12	q14		NCBI
Human Genome Assembly	12	56,428,271 - 56,432,431		NCBI