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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:Trail mediated signaling pathway
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Accession:PW:0000682 term browser browse the term
Definition:Trail-mediated signaling leads to apoptosis via assembly of the DISC complex (Death-Inducing Signaling Complex) downstream of its receptors.
Synonyms:related_synonym: TRAIL signaling;   TRAIL-activated apoptotic signaling pathway
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Trail mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist ISO RGD PMID:17403612 PMID:19961901 RGD:4143170, RGD:4143171 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Casp3 caspase 3 ISO RGD PMID:17403612 PMID:19961901 RGD:4143170, RGD:4143171 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 ISO RGD PMID:19961901 RGD:4143171 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 ISO PID
RGD		 PMID:17403612 PMID:19961901 PID:200068, RGD:4143170, RGD:4143171 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator ISO PID
RGD		 PMID:17403612 PMID:19961901 PID:200068, RGD:4143170, RGD:4143171 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200068 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Dap3 death associated protein 3 ISO PID PID:200068 NCBI chr 2:176,617,151...176,645,293
Ensembl chr 2:176,617,155...176,644,270 		JBrowse link
G Fadd Fas associated via death domain ISO PID
RGD		 PMID:17403612 PMID:19961901 PID:200068, RGD:4143170, RGD:4143171 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200068 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID PID:200068 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:157,367,639...157,392,757 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 ISO PID PID:200068 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200068 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO PID PID:200068 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO PID PID:200068 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200068 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200068 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta ISO PID PID:200068 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta ISO PID PID:200068 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200068 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO PID PID:200068 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 ISO PID PID:200068 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO PID PID:200068 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO PID PID:200068 NCBI chr 1:169,304,772...169,308,615
Ensembl chr 1:169,304,708...169,308,614 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b IMP
ISO 		PID
RGD		 PMID:19934367 PMID:17403612 PMID:19961901 PID:200068, RGD:4142856, RGD:4143170, RGD:4143171 NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082 		JBrowse link
G Tnfrsf22 tumor necrosis factor receptor superfamily, member 22 ISO PID PID:200068 NCBI chr 1:208,269,844...208,285,823
Ensembl chr 1:208,258,836...208,289,832 		JBrowse link
G Tnfsf10 TNF superfamily member 10 IMP
ISO 		PID
RGD		 PMID:19385008 PMID:17403612 PMID:19961901 PID:200068, RGD:2312745, RGD:4143170, RGD:4143171 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tradd TNFRSF1A-associated via death domain ISO PID PID:200068 NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO PID PID:200068 NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      cytokine and chemokine mediated signaling pathway 570
        cytokine mediated signaling pathway 485
          tumor necrosis factor superfamily mediated signaling pathway 88
            Trail mediated signaling pathway 28
              altered Trail mediated signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      cell death pathway 243
        programmed cell death pathway 243
          apoptotic cell death pathway 162
            extrinsic apoptotic pathway 88
              Trail mediated signaling pathway 28
                altered Trail mediated signaling pathway 0
paths to the root