| 10510 | Egf | epidermal growth factor | This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and fun ction in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the encoded protein do not exhibit an abnormal phenotype but transgenic mice overexpressing the encoded protein exhibit hypospermatogenesis. [provided by RefSeq, Jul 2016] | 3 | 129471223 | 129548971 | Mouse | 782 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1553497 | Adgre1 | adhesion G protein-coupled receptor E1 | Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; ge nitourinary system; hemolymphoid system; and intestine. Orthologous to human ADGRE1 (adhesion G protein-coupled receptor E1). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 57665650 | 57790527 | Mouse | 198 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1550875 | Adgre4 | adhesion G protein-coupled receptor E4 | Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within epidermal growth factor receptor signaling pathway. Located in cell surface. Is expressed in alimenta ry system; gonad; and metanephros. Orthologous to human ADGRE4P (adhesion G protein-coupled receptor E4, pseudogene). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 56056984 | 56160662 | Mouse | 78 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1332497 | Egfl7 | EGF-like domain 7 | Enables Notch binding activity. Involved in vasculogenesis. Acts upstream of or within negative regulation of smooth muscle cell migration. Located in extracellular space. Is expressed in several structures, including cardiovascular system; early conceptus; embryo mesenchyme; genitourinary system; a nd retina. Orthologous to human EGFL7 (EGF like domain multiple 7). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 26471095 | 26482694 | Mouse | 130 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1615005 | Egfl8 | EGF-like domain 8 | Predicted to enable signaling receptor binding activity. Predicted to be involved in vasculogenesis. Predicted to be active in cell surface and extracellular region. Is expressed in several structures, including diaphragm; genitourinary system; gut; hemolymphoid system gland; and trigeminal nerve. O rthologous to human EGFL8 (EGF like domain multiple 8). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 34832174 | 34835536 | Mouse | 47 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1557004 | Egfl6 | EGF-like-domain, multiple 6 | Predicted to enable calcium ion binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; lung; and skin . Orthologous to human EGFL6 (EGF like domain multiple 6). [provided by Alliance of Genome Resources, Jul 2025] | X | 165306003 | 165368712 | Mouse | 93 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736663 | Megf6 | multiple EGF-like-domains 6 | Predicted to enable calcium ion binding activity and scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Located in collagen-containing extracellular matrix. Is expressed in several structures, including embryo mesenchyme; head bone; intraembryonic coelom; pharyngo-t ympanic tube; and submandibular gland primordium. Orthologous to human MEGF6 (multiple EGF like domains 6). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 154255156 | 154360178 | Mouse | 117 | symbol , old_gene_name , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737435 | Megf8 | multiple EGF-like-domains 8 | Predicted to enable calcium ion binding activity. Involved in several processes, including BMP signaling pathway; embryonic organ development; and fasciculation of sensory neuron axon. Acts upstream of or within several processes, including circulatory system development; determination of digestive tract left/right asymmetry; and embryonic brain development. Located in nucleus. Part of ubiquitin ligase complex. Is expressed in several structures, including branchial arch; ganglia; heart; limb bud; and telencephalon. Used to study Carpenter syndrome and visceral heterotaxy. Human ortholog(s) of this gene implicated in Carpenter syndrome 2. Orthologous to human MEGF8 (multiple EGF like domains 8). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 25016589 | 25065342 | Mouse | 216 | symbol , old_gene_name , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1318038 | Megf9 | multiple EGF-like-domains 9 | Predicted to be involved in several processes, including axon guidance; basement membrane assembly; and substrate adhesion-dependent cell spreading. Located in basement membrane. Is expressed in several structures, including eye; gut epithelium; nervous system; olfactory epithelium; and skin. Orthol ogous to human MEGF9 (multiple EGF like domains 9). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 70350164 | 70453165 | Mouse | 85 | symbol , old_gene_name , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1558549 | Megf10 | multiple EGF-like-domains 10 | Enables Notch binding activity. Involved in several processes, including myoblast development; positive regulation of myoblast proliferation; and skeletal muscle satellite cell proliferation. Acts upstream of or within apoptotic process involved in development; engulfment of apoptotic cell; and reco gnition of apoptotic cell. Located in phagocytic cup. Is expressed in several structures, including brain; heart; retina layer; skeletal muscle tissue; and testis. Human ortholog(s) of this gene implicated in congenital myopathy 10B and early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to human MEGF10 (multiple EGF like domains 10). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 57266162 | 57430539 | Mouse | 143 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1557497 | Megf11 | multiple EGF-like-domains 11 | Predicted to enable scavenger receptor activity. Involved in homotypic cell-cell adhesion and retina layer formation. Predicted to be located in basolateral plasma membrane. Is expressed in heart; nervous system; and retina layer. Orthologous to human MEGF11 (mu ltiple EGF like domains 11). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 64291556 | 64618584 | Mouse | 68 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1617601 | Cripto | cripto, EGF-CFC family member | Enables several functions, including Wnt-protein binding activity; coreceptor activity; and nodal binding activity. Involved in several processes, including morphogenesis of a branching structure; nodal signaling pathway; and positive regulation of cell migration. Acts upstream of or within several processes, including circulatory system development; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of fibroblast proliferation. Located in several cellular components, including Golgi apparatus; cell surface; and perinuclear region of cytoplasm. Is expressed in several structures, including blastocyst; brain; extraembryonic component; gonad; and heart. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Orthologous to several human genes including CRIPTO (cripto, EGF-CFC family member). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 110768676 | 110775226 | Mouse | 194 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1557732 | Cfc1 | cryptic, EGF-CFC family member 1 | Enables activin receptor binding activity. Involved in nodal signaling pathway. Acts upstream of or within several processes, including heart development; left lung morphogenesis; and spleen development. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracell ular region. Is expressed in several structures, including embryo mesoderm; intermediate mesenchyme; neural ectoderm; and primitive streak. Used to study dextro-looped transposition of the great arteries; double outlet right ventricle; right atrial isomerism; and visceral heterotaxy. Human ortholog(s) of this gene implicated in tetralogy of Fallot; visceral heterotaxy; and visceral heterotaxy 2. Orthologous to several human genes including CFC1B (cryptic, EGF-CFC family member 1B). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 34574729 | 34583392 | Mouse | 111 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1316291 | Egfem1 | EGF-like and EMI domain containing 1 | Predicted to enable calcium ion binding activity. Orthologous to human EGFEM1P (EGF like and EMI domain containing 1, pseudogene). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 29135695 | 29831923 | Mouse | 38 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1551256 | Creld1 | cysteine-rich with EGF-like domains 1 | Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be an extracellular matrix structural constituent. Is active in glutamatergic synapse. Is expressed in branchial arch; heart; and nervous system. Human ortholog(s) of this gene implicated in atrio ventricular septal defect and heart septal defect. Orthologous to human CRELD1 (cysteine rich with EGF like domains 1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 113460317 | 113470304 | Mouse | 120 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1321619 | Creld2 | cysteine-rich with EGF-like domains 2 | Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be an extracellular matrix structural constituent. Located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including alimentary system; brai n; genitourinary system; long bone; and respiratory system. Orthologous to human CRELD2 (cysteine rich with EGF like domains 2). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 88703849 | 88710884 | Mouse | 166 | old_gene_name , name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1558447 | Sned1 | sushi, nidogen and EGF-like domains 1 | Predicted to enable Notch binding activity. Predicted to be involved in cell-matrix adhesion. Located in extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; limb interdigital region; and mesothelium. Orthologous to human S NED1 (sushi, nidogen and EGF like domains 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 93163563 | 93228787 | Mouse | 91 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1550695 | Dner | delta/notch-like EGF repeat containing | Enables Notch binding activity. Acts upstream of or within Notch receptor processing; glial cell differentiation; and skeletal muscle fiber development. Located in dendrite and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; limb; peripher al nervous system ganglion; and sensory organ. Orthologous to human DNER (delta/notch like EGF repeat containing). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 84347560 | 84673942 | Mouse | 171 | old_gene_name , name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1552258 | Hbegf | heparin-binding EGF-like growth factor | Enables epidermal growth factor receptor binding activity; heparin binding activity; and signaling receptor activator activity. Involved in several processes, including ERBB2 signaling pathway; positive regulation of keratinocyte migration; and wound healing, spreading of epidermal cells. Acts upstr eam of or within several processes, including epidermal growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of heart contraction. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; heart; submandibular gland primordium; and telencephalon. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 36637980 | 36648858 | Mouse | 486 | symbol , old_gene_name , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1319122 | Scube1 | signal peptide, CUB domain, EGF-like 1 | Predicted to enable identical protein binding activity. Acts upstream of or within positive regulation of smoothened signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be active in cell surface and extracellular space. Is expressed in several structures, inc luding allantois; embryo ectoderm; embryo mesenchyme; forelimb bud; and genitourinary system. Orthologous to human SCUBE1 (signal peptide, CUB domain and EGF like domain containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 83486784 | 83609252 | Mouse | 111 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1617561 | Scube2 | signal peptide, CUB domain, EGF-like 2 | Enables hedgehog family protein binding activity. Acts upstream of or within several processes, including chondrocyte differentiation involved in endochondral bone morphogenesis; positive regulation of chondrocyte proliferation; and positive regulation of osteoblast differentiation. Located in extra cellular space. Is expressed in several structures, including cardiovascular system; central nervous system; neural ectoderm; sensory organ; and skeleton. Orthologous to human SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 109397897 | 109464886 | Mouse | 115 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1614840 | Scube3 | signal peptide, CUB domain, EGF-like 3 | Predicted to enable BMP binding activity; BMP receptor binding activity; and identical protein binding activity. Involved in positive regulation of osteoblast differentiation. Acts upstream of or within positive regulation of smoothened signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracellular space. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; integumental system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2. Orthologous to human SCUBE3 (signal peptide, CUB domain and EGF like domain containing 3). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 28361074 | 28393825 | Mouse | 165 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1332003 | Vwce | von Willebrand factor C and EGF domains | Predicted to enable calcium ion binding activity. Predicted to be involved in cellular response to virus. Predicted to be located in extracellular region. Predicted to be active in cytoplasm. Is expressed in left lung; mandible; maxilla; orbito-sphenoid; and right lung. Orthologous to human VWCE (vo n Willebrand factor C and EGF domains). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 10611582 | 10643577 | Mouse | 96 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1614921 | Vwde | von Willebrand factor D and EGF domains | Predicted to be located in extracellular region. Is expressed in tooth. Orthologous to human VWDE (von Willebrand factor D and EGF domains). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 13156439 | 13224964 | Mouse | 42 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1551471 | Ccbe1 | collagen and calcium binding EGF domains 1 | Predicted to enable collagen binding activity and protease binding activity. Involved in positive regulation of angiogenesis and positive regulation of lymphangiogenesis. Acts upstream of or within several processes, including lymphangiogenesis; positive regulation of endothelial cell migration; and respiratory system process. Predicted to be located in extracellular matrix and extracellular space. Predicted to be part of collagen trimer. Is expressed in several structures, including anterior cardinal vein; branchial arch; embryo mesenchyme; heart; and intraembryonic coelom. Human ortholog(s) of this gene implicated in Hennekam syndrome. Orthologous to human CCBE1 (collagen and calcium binding EGF domains 1). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 66189926 | 66424909 | Mouse | 163 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1558142 | Celsr1 | cadherin, EGF LAG seven-pass G-type receptor 1 | Predicted to enable calcium ion binding activity. Involved in establishment of planar polarity and neural tube closure. Acts upstream of or within several processes, including apical protein localization; morphogenesis of an epithelium; and motor neuron migration. Located in membrane. Is expressed i n several structures, including central nervous system; epithelium; primitive streak; renal cortex; and skin. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 85782959 | 85918424 | Mouse | 250 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736028 | Celsr2 | cadherin, EGF LAG seven-pass G-type receptor 2 | Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in several processes, including Wnt signaling pathway; homophilic cell adhesion via plasma membrane adhesion molecules; and neural plate anterior/posterior regionalization. Acts upstream of or within s everal processes, including cerebrospinal fluid secretion; cilium assembly; and nervous system development. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; skin; and visual system. Used to study hydrocephalus. Orthologous to human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 108298164 | 108323416 | Mouse | 154 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732288 | Celsr3 | cadherin, EGF LAG seven-pass G-type receptor 3 | Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in Wnt signaling pathway, planar cell polarity pathway; dopaminergic neuron axon guidance; and serotonergic neuron axon guidance. Acts upstream of or within several processes, including cilium assembly ; generation of neurons; and regulation of protein phosphorylation. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Is expressed in several structures, including central nervous system; embryo ectoderm; epiblast; peripheral nervous system; and retina. Orthologous to human CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 108703244 | 108730168 | Mouse | 151 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1557383 | Edil3 | EGF-like repeats and discoidin I-like domains 3 | Predicted to enable calcium ion binding activity. Acts upstream of or within positive regulation of cell-substrate adhesion. Predicted to be located in extracellular region. Is expressed in several structures, including cartilage; cerebral cortex; heart; skeletal system; and trachea. Orthologous to human EDIL3 (EGF like repeats and discoidin domains 3). [provided by Alliance of Genome Resources, Apr 2025] | 13 | 88969591 | 89471344 | Mouse | 656 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1558285 | Heg1 | heart development protein with EGF-like domains 1 | Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including circulatory system development; endothelial cell morphogenesis; and lymph circulation. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, inc luding alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Orthologous to human HEG1 (heart development protein with EGF like domains 1). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 33504754 | 33591946 | Mouse | 189 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1332080 | Egflam | EGF-like, fibronectin type III and laminin G domains | Enables glycosaminoglycan binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane and interstitial matrix. Is active in photoreceptor ribbon synapse. Is expressed in hair follicle and rib. Ortholo gous to human EGFLAM (EGF like, fibronectin type III and laminin G domains). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 7235598 | 7428203 | Mouse | 108 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 10895 | Mfge8 | milk fat globule EGF and factor V/VIII domain containing | Enables integrin binding activity. Involved in apoptotic cell clearance. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including central nervous system; extraembryonic component; hemolymphoid system; integumental system; and reproductive sys tem. Human ortholog(s) of this gene implicated in temporal arteritis. Orthologous to human MFGE8 (milk fat globule EGF and factor V/VIII domain containing). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 78783516 | 78798808 | Mouse | 224 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1550671 | Eogt | EGF domain specific O-linked N-acetylglucosamine transferase | Enables protein O-acetylglucosaminyltransferase activity. Involved in protein O-linked glycosylation. Predicted to be active in endoplasmic reticulum lumen. Is expressed in several structures, including blood vessel; central nervous system; limb; lung; and tail unsegmented mesenchyme. Human ortholog (s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 97086977 | 97128445 | Mouse | 94 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1551713 | Tie1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in circulatory system development; response to retinoic acid; and tissue remodeling. Acts upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculat ure development. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 118328388 | 118347046 | Mouse | 177 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 62297 | Tmeff1 | transmembrane protein with EGF-like and two follistatin-like domains 1 | Predicted to enable receptor ligand inhibitor activity. Involved in host-mediated suppression of symbiont invasion. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Orthologous to seve ral human genes including TMEFF1 (transmembrane protein with EGF like and two follistatin like domains 1). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 48585064 | 48663136 | Mouse | 93 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1318844 | Tmeff2 | transmembrane protein with EGF-like and two follistatin-like domains 2 | Predicted to be involved in cell differentiation. Predicted to act upstream of or within negative regulation of cell migration; negative regulation of cellular component organization; and wound healing, spreading of cells. Predicted to be located in membrane. Predicted to be active in extracellular region. Is expressed in several structures, including gut; nervous system; prostate gland; vibrissa; and white fat. Human ortholog(s) of this gene implicated in prostate cancer and urinary bladder cancer. Orthologous to human TMEFF2 (transmembrane protein with EGF like and two follistatin like domains 2). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 50951946 | 51226429 | Mouse | 142 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1557866 | Svep1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | Enables chromatin binding activity and integrin binding activity involved in cell-matrix adhesion. Involved in positive regulation of platelet activation. Acts upstream of or within several processes, including Tie signaling pathway; lymph circulation; and lymph vessel morphogenesis. Located in extr acellular space. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver sinusoid; and respiratory system. Orthologous to human SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 58042796 | 58206596 | Mouse | 168 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1619279 | Egfbp2 | epidermal growth factor binding protein type B | The protein encoded by this gene belongs to the kallikrein family, which is a highly homologous group of serine proteases encoded by a cluster of related genes on chromosome 7. This gene has been shown to function as both a prorenin converting enzyme and as epidermal growth factor (EGF -weight:700;'>EGF)-binding protein involved in the maturation of EGF (PMIDs: 1918045, 3322387, 9685728). This gene is thought to be distinct from Klk1b26 gene (GeneID:16618), with which it shares 98% identity (PMID:1959648, 9685728), however, it is not clear if both genes are present in all strains of mice. Blast analyses suggest that this gene is missing from the current reference (GRCm38, based on C57BL/6J genome) and alternate Celera (based on mixed strain genomes) assemblies. Therefore, the RefSeq for this locus was based on sequence from the ICR strain, which has been reported in literature (PMID:1959648) to contain both genes. [provided by RefSeq, Aug 2012] | | | | Mouse | 27 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1619280 | Klk1b22 | kallikrein 1-related peptidase b22 | This gene encodes the beta subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. The encoded preproprotein undergoes proteolytic processing to generate a fu nctional, mature peptide. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016] | 7 | 43762097 | 43766346 | Mouse | 34 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1619278 | Klk1b9 | kallikrein 1-related peptidase b9 | This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic clea vage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016] | 7 | 43625485 | 43629800 | Mouse | 22 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733023 | Klk1b26 | kallikrein 1-related petidase b26 | This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. The kallikrein genes are present in a large gene cluster on chromosome 7. The encoded preproprotein is proteolytically processed to generate a mature protein product. Expression of this gene in the submandibular gland is sexually dimorphic likely due to both transcriptional and post-transcriptional regulation. This gene is thought to be distinct from the Egfbp2 gene (Gene ID: 13647), with which it shares 98% identity (PMIDs: 1959648, 9685728), however, it is not clear if both genes are present in all strains of mice. [provided by RefSeq, Sep 2015] | 7 | 43662102 | 43666393 | Mouse | 35 | old_gene_name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1313718 | Adgre5 | adhesion G protein-coupled receptor E5 | Predicted to enable G protein-coupled receptor activity and chondroitin sulfate binding activity. Acts upstream of or within positive regulation of synapse assembly. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in vibratory urticaria. Orthologous to several human genes including ADGRE5 (adhesion G protein-coupled receptor E5). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 84449874 | 84467812 | Mouse | 142 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 732484 | Adgrl4 | adhesion G protein-coupled receptor L4 | Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and protein-containing complex assembly. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Is expres sed in brain; cardiovascular system; lung; metanephros; and skeletal muscle. Orthologous to human ADGRL4 (adhesion G protein-coupled receptor L4). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 151143519 | 151250718 | Mouse | 118 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1319321 | Dlk2 | delta like non-canonical Notch ligand 2 | Enables identical protein binding activity. Involved in regulation of fat cell differentiation. Acts upstream of or within negative regulation of Notch signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; brain; limb mesenchyme; met anephros; and musculoskeletal system. Orthologous to human DLK2 (delta like non-canonical Notch ligand 2). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 46608342 | 46614197 | Mouse | 80 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1557020 | Itgbl1 | integrin, beta-like 1 | Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to be located in extracellular region. Predicted to be part of integrin complex. Predic ted to be active in cell surface and focal adhesion. Is expressed in axial skeleton; brain; heart ventricle; meninges; and vibrissa. Orthologous to human ITGBL1 (integrin subunit beta like 1). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 123897331 | 124215173 | Mouse | 91 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1313808 | Pear1 | platelet endothelial aggregation receptor 1 | Enables signaling receptor activity. Involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction; platelet aggregation; and positive regulation of platelet activation. Acts upstream of or within recognition of apoptotic cell. Located in phagocytic cup. Is active in plasma membrane . Is expressed in brain; dorsal root ganglion; embryo; heart; and spinal cord. Orthologous to human PEAR1 (platelet endothelial aggregation receptor 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 87656404 | 87676262 | Mouse | 97 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1316134 | Kctd11 | potassium channel tetramerisation domain containing 11 | Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including negative regulation of neuroblast proliferation; negative regulation of smoothened signaling pathway; and positive regulation of neuron differentiation. Located in cytoplasm. Is expressed in several structures, including 1st branchial arch; central nervous system; ectoplacental cone; primitive streak; and sensory organ. Orthologous to human KCTD11 (potassium channel tetramerization domain containing 11). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 69769090 | 69771811 | Mouse | 76 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1552464 | Tek | TEK receptor tyrosine kinase | Enables protein tyrosine kinase activity and signaling receptor activity. Involved in several processes, including circulatory system development; negative regulation of endothelial cell apoptotic process; and response to retinoic acid. Acts upstream of or within several processes, including positiv e regulation of macromolecule metabolic process; positive regulation of protein import into nucleus; and regulation of non-canonical NF-kappaB signal transduction. Located in perinuclear region of cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in arteriovenous malformation; multiple cutaneous and mucosal venous malformations; and renal Wilms' tumor. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 94627322 | 94763213 | Mouse | 368 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1614982 | Npnt | nephronectin | Enables integrin binding activity. Involved in several processes, including cell-cell adhesion mediated by integrin; pilomotor reflex; and positive regulation of metabolic process. Acts upstream of or within several processes, including branching involved in ureteric bud morphogenesis; positive regu lation of cell-substrate adhesion; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in several cellular components, including basement membrane; collagen-containing extracellular matrix; and smooth muscle contractile fiber. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study bilateral renal aplasia. Orthologous to human NPNT (nephronectin). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 132587506 | 132656052 | Mouse | 141 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 736146 | Fbln5 | fibulin 5 | Enables integrin binding activity. Involved in several processes, including elastic fiber assembly; intramembranous bone growth; and regulation of transcription by RNA polymerase II. Acts upstream of or within extracellular matrix organization. Located in extracellular space. Colocalizes with collag en-containing extracellular matrix and elastic fiber. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and skeleton. Used to study cutis laxa. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; age related macular degeneration; autosomal dominant cutis laxa 2; autosomal recessive cutis laxa type IA; and cutis laxa. Orthologous to human FBLN5 (fibulin 5). [provided by Alliance of Genome Resources, Apr 2025] | 12 | 101712820 | 101785541 | Mouse | 240 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1318352 | Efemp1 | epidermal growth factor-containing fibulin-like extracellular matrix protein 1 | Predicted to enable epidermal growth factor receptor activity and epidermal growth factor receptor binding activity. Predicted to be involved in several processes, including negative regulation of chondrocyte differentiation; peptidyl-tyrosine phosphorylation; and regulation of cell projection organ ization. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; male reproductive gland or organ; and skeleton. Used to study Doyne honeycomb retinal dystrophy. Human ortholog(s) of this gene implicated in Doyne honeycomb retinal dystrophy and cutis laxa. Orthologous to human EFEMP1 (EGF containing fibulin extracellular matrix protein 1). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 28803154 | 28876743 | Mouse | 309 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1551771 | Efemp2 | epidermal growth factor-containing fibulin-like extracellular matrix protein 2 | Predicted to enable heparin binding activity and protein homodimerization activity. Involved in several processes, including elastic fiber assembly; negative regulation of vascular associated smooth muscle cell proliferation; and vasculature development. Acts upstream of or within artery development . Located in basement membrane; elastic fiber; and microfibril. Is expressed in several structures, including central nervous system; genitourinary system; gut; immune system; and respiratory system. Used to study aortic aneurysm and cutis laxa. Human ortholog(s) of this gene implicated in aortic aneurysm; arterial tortuosity syndrome; autosomal recessive cutis laxa type IB; endometrial cancer; and osteosarcoma. Orthologous to human EFEMP2 (EGF containing fibulin extracellular matrix protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 5523974 | 5532548 | Mouse | 231 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 735589 | Cspg5 | chondroitin sulfate proteoglycan 5 | This gene encodes a chondroitin sulfate proteoglycan. The encoded protein has been termed a 'part-time' proteoglycan, as chondroitin sulfate chains appear to be attached to the protein in the developing but not the adult cerebellum and retina. It is thought that this protein plays roles in dendrite branching and synapse formation. [provided by RefSeq, Oct 2009] | 9 | 110072851 | 110091644 | Mouse | 114 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1321167 | Stab1 | stabilin 1 | Predicted to enable low-density lipoprotein particle binding activity; low-density lipoprotein particle receptor activity; and scavenger receptor activity. Predicted to be involved in cell-cell signaling; defense response to bacterium; and negative regulation of angiogenesis. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including blood; cardiovascular system; early conceptus; genitourinary system; and retina nuclear layer. Orthologous to human STAB1 (stabilin 1). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 30860974 | 30890616 | Mouse | 135 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1615743 | Stab2 | stabilin 2 | Enables cargo receptor activity. Involved in hyaluronan catabolic process and receptor-mediated endocytosis. Predicted to be located in cytosol and external side of plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; heart; and liver. O rthologous to human STAB2 (stabilin 2). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 86677058 | 86843902 | Mouse | 119 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 10511 | Egfr | epidermal growth factor receptor | Enables epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in ERBB2-EGFR signaling pathway; cellular response to amino acid stimulus; and positive regulation of fibroblast proliferation. Acts upstream of or within se veral processes, including eyelid development in camera-type eye; protein modification process; and regulation of epidermal growth factor receptor signaling pathway. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and sensory organ. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 16700153 | 16868158 | Mouse | 1900 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1612813 | Egfros | epidermal growth factor receptor, opposite strand | | 11 | 16760001 | 16780750 | Mouse | 3 | symbol , PhenoGen | gene, ncrna, MODEL [RefSeq] |
| 1312891 | Rhbdf1 | rhomboid 5 homolog 1 | Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including negative regulation of protein secretion; regulation of epidermal growth factor receptor signaling pathway; and regulation of proteasomal protein catabolic process. Predicted to be locate d in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; eye; and genitourinary system. Orthologous to human RHBDF1 (rhomboid 5 homolog 1). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 32159585 | 32172339 | Mouse | 187 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1621802 | Klk13 | kallikrein related-peptidase 13 | Kallikreins are serine proteases encoded by a cluster of highly related genes on chromosome 7. When genomic sequence became available, it was possible to clarify the gene-to-sequence relationship for this family. Until January, 2006, NM_010115 was called kallikrein 13. After that time, NM_001039042 was called Klk13 and NM_010115 was called Klk1b26. [provided by RefSeq, Jul 2008] | 7 | 43361991 | 43377288 | Mouse | 58 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1617450 | Nup210l | nucleoporin 210-like | Acts upstream of or within Sertoli cell development and spermatid development. Predicted to be located in membrane. Predicted to be part of nuclear pore. Orthologous to human NUP210L (nucleoporin 210 like). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 90011445 | 90119458 | Mouse | 50 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1618321 | 1700016L21Rik | RIKEN cDNA 1700016L21 gene | ASSOCIATED WITH abnormal alveolar macrophage morphology; abnormal CD8-positive, alpha-beta T cell differentiation; abnormal circulating cytokine level | 1 | 80423649 | 80453377 | Mouse | 56 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 11411 | Tgfa | transforming growth factor alpha | This gene encodes a member of the epidermal growth factor (EGF) family of proteins that regulate cellular proliferation. The encoded protein undergoes proteolytic processing to generate a soluble glycoprotein that is secreted by the cell. The secreted protein bi nds to the EGF receptors to initiate signaling events resulting in cellular proliferation, mucous production or inhibition of gastric acid secretion. The transgenic expression of the encoded protein in mice induces the development of cancers in various tissues such as liver, pancreas, skin and mammary glands. Mice lacking the encoded protein exhibit a wavy coat and curly whiskers phenotype as well as abnormalities in the eye. [provided by RefSeq, Sep 2015] | 6 | 86172020 | 86252726 | Mouse | 492 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735336 | Akt1 | Akt serine/threonine kinase 1 | This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived g rowth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] | 12 | 112620260 | 112641266 | Mouse | 3292 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 736382 | Areg | amphiregulin | This gene encodes a member of the epidermal growth factor (EGF) family and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein is a ligand of the epidermal growth factor receptor (EGF ;'>EGFR) and has been shown to play a role in immunity, inflammation, tissue repair, and lung and mammary gland development. Homozygous knockout mice for this gene exhibit impaired immune system regulation in the skin and gene expression changes characteristic of chronic liver damage. [provided by RefSeq, Aug 2015] | 5 | 91287458 | 91296291 | Mouse | 486 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 733574 | Btc | betacellulin, epidermal growth factor family member | This gene encodes a member of the epidermal growth factor (EGF) family. These growth factors are ligands for the EGFR/ErbB receptor tyrosine kinases, and play roles in cell growth and differentiation. The encoded protein is synthesized as a transmembrane precursor that is proteolytically cleaved to generate a mature peptide, and plays a role in the differentiation of pancreatic beta cells. This gene may also play a protective role in acute pancreatitis, whereas increased expression of this gene may contribute to diabetic macular edema. Gene therapy using combinations of this gene and other pancreas-specific transcription factors may induce islet neogenesis and remediate hyperglycemia in type 1 diabetes. [provided by RefSeq, Apr 2011] | 5 | 91505120 | 91550853 | Mouse | 163 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1553035 | Nrxn3 | neurexin III | This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants for this gene, but the full-length nature of many of these vari ants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. [provided by RefSeq, Dec 2012] | 12 | 88689454 | 90301709 | Mouse | 204 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1332013 | Poglut1 | protein O-glucosyltransferase 1 | This gene encodes a protein that can catalyze transfer of either UDP-glucose or UDP-xylose to epidermal growth factor (EGF) repeats, such as those found in Notch. Loss of this gene product results in embryonic lethality. Embryos have neural plate defects, heart defects, and truncations of their posterior axis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] | 16 | 38345420 | 38370619 | Mouse | 158 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 69005 | Stat3 | signal transducer and activator of transcription 3 | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription ac tivators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015] | 11 | 100777632 | 100830447 | Mouse | 1950 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1614315 | Eldr | Egfr long non-coding downstream RNA | Acts upstream of or within regulation of gene expression and response to wounding. Is expressed in brain; cortical layer VI; neocortex; telencephalon mantle layer; and telencephalon ventricular layer. Orthologous to human ELDR (EGFR long non-coding downstream RN A). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 16884709 | 16901282 | Mouse | 9 | name , description | gene, ncrna, VALIDATED [RefSeq] |
| 1315143 | Vopp1 | vesicular, overexpressed in cancer, prosurvival protein 1 | Predicted to enable enzyme binding activity. Predicted to be located in cytoplasmic vesicle membrane; late endosome; and lysosome. Predicted to be active in organelle membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourina ry system; and neural retina. Orthologous to human VOPP1 (VOPP1 WW domain binding protein). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 57729249 | 57802110 | Mouse | 106 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1321588 | Eps8 | epidermal growth factor receptor pathway substrate 8 | Enables actin binding activity and small GTPase binding activity. Involved in several processes, including Rac protein signal transduction; actin filament organization; and barbed-end actin filament capping. Acts upstream of or within several processes, including adult locomotory behavior; behaviora l response to ethanol; and cellular response to leukemia inhibitory factor. Located in several cellular components, including brush border; ruffle membrane; and stereocilium tip. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; bone; brain; and metanephros. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (EGFR pathway substrate 8, signaling adaptor). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 137454242 | 137626262 | Mouse | 222 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1621212 | Nell1 | NEL-like 1 | Predicted to enable heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including negative regulation of osteoblast proliferation; positive regulation of bone mineralization; and positive regulation of os teoblast differentiation. Predicted to be located in nuclear envelope and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including basal columns; chondrocranium; tooth; tooth bud; and urinary system. Orthologous to human NELL1 (neural EGFL like 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 49625098 | 50513037 | Mouse | 176 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732317 | Nell2 | NEL-like 2 | Enables identical protein binding activity. Involved in commissural neuron axon guidance and fertilization. Located in extracellular region. Is expressed in several structures, including alimentary system; autopod; central nervous system; limb mesenchyme; and sensory organ. Orthologous to human NELL 2 (neural EGFL like 2). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 95117321 | 95426677 | Mouse | 152 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1551749 | Shc1 | src homology 2 domain-containing transforming protein C1 | Enables epidermal growth factor binding activity; identical protein binding activity; and signaling receptor binding activity. Involved in insulin-like growth factor receptor signaling pathway. Acts upstream of or within several processes, including circulatory system development; epidermal growth f actor receptor signaling pathway; and positive regulation of MAPK cascade. Predicted to be located in endosome membrane. Predicted to be part of Shc-EGFR complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cerebral cortex; early conceptus; liver; skeleton; and skin. Orthologous to human SHC1 (SHC adaptor protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 89325858 | 89337336 | Mouse | 426 | description | gene, protein-coding, VALIDATED [RefSeq] |
