| 1306461 | Usp1 | ubiquitin specific peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); peptidase activity (ortholog); INVOLVED IN monoubiquitinated protein deubiquitination (ortholog); positive regulation of receptor signaling pathway via JAK-STAT (ortholog); protein deubiquitination (ortholog); ASSOCIAT ED WITH Fanconi anemia (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 118703056 | 118714426 | Rat | 137 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1315093 | USP1 | ubiquitin specific peptidase 1 | This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The prot ein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] | 1 | 62436395 | 62451804 | Human | 129 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1315094 | Usp1 | ubiquitin specific peptidase 1 | This gene encodes a member of the ubiquitin-specific peptidase family. The encoded protein acts as a catalytic subunit in a heterodimeric deubiquitinating enzyme complex that deubiquitinates Fanconi anemia, complementation group D2, and plays a role in homologous recombination-mediated DNA repair. D isruption of this gene is associated with a Fanconi anemia-like phenotype and genomic instability. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 3, 12, and 15. [provided by RefSeq, Aug 2014] | 4 | 98812047 | 98823780 | Mouse | 174 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8902345 | Usp1 | ubiquitin specific peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); peptidase activity (ortholog); INVOLVED IN monoubiquitinated protein deubiquitination (ortholog); positive regulation of receptor signaling pathway via JAK-STAT (ortholog); protein deubiquitination (ortholog); ASSOCIAT ED WITH Fanconi anemia (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | NW_004955423 | 27236242 | 27254064 | Chinchilla | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11830051 | USP1 | ubiquitin specific peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN skeletal system development (ortholog); ASSOCIATED WITH Fanconi anemia (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | 1 | 61694775 | 61710216 | Bonobo | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12224916 | USP1 | ubiquitin specific peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN skeletal system development (ortholog); ASSOCIATED WITH Fanconi anemia (ortholog); FOUND IN nucleoplasm (inferre d); nucleus (inferred) | 5 | 47655533 | 47666767 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12569277 | Usp1 | ubiquitin specific peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN skeletal system development (ortholog); ASSOCIATED WITH Fanconi anemia (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936692 | 147699 | 159921 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13992361 | USP1 | ubiquitin specific peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN skeletal system development (ortholog); ASSOCIATED WITH Fanconi anemia (ortholog); FOUND IN nucleoplasm (inferre d); nucleus (inferred) | | | | Pig | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14389758 | Usp1 | | | | | | Fly | | symbol | gene, null |
| 18464593 | USP1 | ubiquitin specific peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN skeletal system development (ortholog); ASSOCIATED WITH Fanconi anemia (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18919437 | Usp1 | ubiquitin specific peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN monoubiquitinated protein deubiquitination (ortholog); positive regulation of receptor signaling pathway via JAK -STAT (ortholog); response to UV (ortholog); ASSOCIATED WITH Fanconi anemia (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235617 | usp1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625843041 | Usp1 | ubiquitin specific peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); peptidase activity (ortholog); INVOLVED IN monoubiquitinated protein deubiquitination (ortholog); positive regulation of receptor signaling pathway via JAK-STAT (ortholog); protein deubiquitination (ortholog); ASSOCIAT ED WITH Fanconi anemia (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243186 | usp1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155235616 | usp1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1557542 | Usp17lc | ubiquitin specific peptidase 17-like C | Enables cysteine-type deubiquitinase activity. Involved in chordate embryonic development. Acts upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to several human genes i ncluding USP17L11 (ubiquitin specific peptidase 17 like family member 11); USP17L12 (ubiquitin specific peptidase 17 like family member 12); and USP17L15 (ubiquitin specific peptidase 17 like family member 15). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 103065903 | 103068381 | Mouse | 43 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1347511 | WDR48 | WD repeat domain 48 | The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated F ANCD2. FANCD2 is ubiquitinated in response to DNA damage. [provided by RefSeq, Sep 2016] | 3 | 39052016 | 39096664 | Human | 97 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1550376 | Wdr48 | WD repeat domain 48 | Predicted to enable DNA binding activity; deubiquitinase activator activity; and ubiquitin binding activity. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; regulation of protein monoubiquitination; and seminiferous tubule development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in femur. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 119723961 | 119755652 | Mouse | 116 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1352341 | USP10 | ubiquitin specific peptidase 10 | Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein subs trates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013] | 16 | 84700000 | 84779922 | Human | 151 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1558121 | Usp10 | ubiquitin specific peptidase 10 | Predicted to enable several functions, including cysteine-type peptidase activity; p53 binding activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; monoubiquitinated protein deubiquitination; and negative regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosolic ribosome; early endosome; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human USP10 (ubiquitin specific peptidase 10). [provided by Alliance of Genome Resources, Apr 2025] | 8 | 120637099 | 120684299 | Mouse | 180 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1561965 | Usp10 | ubiquitin specific peptidase 10 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); molecular function inhibitor activity (ortholog); INVOLVED IN cellular response to interleukin-1 (ortholog); DNA damage response (ortholog); DNA damage response, signal transduction by p53 class mediator (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); cytosolic ribosome (ortholog); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 19 | 64881255 | 64923522 | Rat | 171 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8970892 | Usp10 | ubiquitin specific peptidase 10 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); molecular function inhibitor activity (ortholog); INVOLVED IN cellular response to interleukin-1 (ortholog); DNA damage response (ortholog); DNA damage response, signal transduction by p53 class mediator (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); cytosolic ribosome (ortholog) | NW_004955541 | 242182 | 296018 | Chinchilla | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11848367 | USP10 | ubiquitin specific peptidase 10 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN autophagy (inferred); cellular response to interleukin-1 (inferred); DNA damage response (inferred); FOUND IN cy toplasm (inferred); cytosol (inferred); cytosolic ribosome (inferred) | 16 | 65367463 | 65447549 | Bonobo | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12228145 | USP10 | ubiquitin specific peptidase 10 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN autophagy (inferred); cellular response to interleukin-1 (inferred); DNA damage response (inferred); FOUND IN cy toplasm (inferred); cytosol (inferred); cytosolic ribosome (inferred) | 5 | 67736215 | 67774756 | Dog | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12643532 | Usp10 | ubiquitin specific peptidase 10 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN autophagy (inferred); cellular response to interleukin-1 (inferred); DNA damage response (inferred); FOUND IN cy toplasm (inferred); cytosol (inferred); cytosolic ribosome (inferred) | NW_004936641 | 3308121 | 3350476 | Squirrel | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13844262 | USP10 | ubiquitin specific peptidase 10 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN autophagy (inferred); cellular response to interleukin-1 (inferred); DNA damage response (inferred); FOUND IN cy toplasm (inferred); cytosol (inferred); cytosolic ribosome (inferred) | | | | Pig | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14389115 | Usp10 | | | | | | Fly | | symbol | gene, null |
| 18379402 | USP10 | ubiquitin specific peptidase 10 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN autophagy (inferred); cellular response to interleukin-1 (inferred); DNA damage response (inferred); FOUND IN cy toplasm (inferred); cytosol (inferred); cytosolic ribosome (inferred) | | | | Green Monkey | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903993 | Usp10 | ubiquitin specific peptidase 10 | ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); molecular function inhibitor activity (ortholog); p53 binding (ortholog); INVOLVED IN cellular response to interleukin-1 (ortholog); innate immune response (ortholog); monoubiquitinated protein deubiquitination (ortholo g); FOUND IN cytosolic ribosome (ortholog); nucleoplasm (ortholog); protein-containing complex (ortholog) | | | | Naked Mole-Rat | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238951 | usp10 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626121882 | Usp10 | ubiquitin specific peptidase 10 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); molecular function inhibitor activity (ortholog); INVOLVED IN cellular response to interleukin-1 (ortholog); DNA damage response (ortholog); DNA damage response, signal transduction by p53 class mediator (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); cytosolic ribosome (ortholog) | | | | Black Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1303052 | Usp11 | ubiquitin specific peptidase 11 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN protein deubiquitination (ortholog); ASSOCIATED WITH bronchiectasis (ortholog); FOUND IN cytosol (ortholog); nu cleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; 6-propyl-2-thiouracil | X | 4026865 | 4043036 | Rat | 93 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1347156 | USP11 | ubiquitin specific peptidase 11 | Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cy steine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008] | X | 47233009 | 47248328 | Human | 105 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1550499 | Usp11 | ubiquitin specific peptidase 11 | Predicted to enable cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; and transcription corepressor binding activity. Predicted to be involved in protein deubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed i n brain; cortical plate; dorsal root ganglion; and spinal cord. Orthologous to human USP11 (ubiquitin specific peptidase 11). [provided by Alliance of Genome Resources, Jul 2025] | X | 20570148 | 20586778 | Mouse | 112 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8938311 | Usp11 | ubiquitin specific peptidase 11 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN protein deubiquitination (ortholog); ASSOCIATED WITH bronchiectasis (ortholog); FOUND IN cytosol (ortholog); nu cleoplasm (ortholog); nucleus (ortholog) | NW_004955516 | 840708 | 858201 | Chinchilla | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11757878 | USP11 | ubiquitin specific peptidase 11 | ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH bronchiectasis (ortholog); FOUND IN nucleus (ortholog) | X | 39669761 | 39685231 | Bonobo | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12405943 | USP11 | ubiquitin specific peptidase 11 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN protein deubiquitination (ortholog); ASSOCIATED WITH bronchiectasis (ortholog); FOUND IN nucleus (ortholog) | X | 40826648 | 40842700 | Dog | 47 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12456074 | Usp11 | ubiquitin specific peptidase 11 | ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH bronchiectasis (ortholog); FOUND IN nucleus (ortholog) | NW_004936502 | 13003214 | 13020772 | Squirrel | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14184272 | USP11 | ubiquitin specific peptidase 11 | ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH bronchiectasis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleo plasm (inferred) | | | | Pig | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18418520 | USP11 | ubiquitin specific peptidase 11 | ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH bronchiectasis (ortholog); FOUND IN nucleus (ortholog) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18905668 | Usp11 | ubiquitin specific peptidase 11 | ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH bronchiectasis (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); nucl eus (ortholog) | | | | Naked Mole-Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626101924 | Usp11 | ubiquitin specific peptidase 11 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); transcription corepressor binding (ortholog); INVOLVED IN protein deubiquitination (ortholog); ASSOCIATED WITH bronchiectasis (ortholog); FOUND IN cytosol (ortholog); nu cleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1308045 | Usp12 | ubiquitin specific peptidase 12 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN cytoplasm (ortholog); nucleus (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A | 12 | 13423625 | 13477547 | Rat | 104 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1317587 | USP12 | ubiquitin specific peptidase 12 | Enables cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Involved in protein deubiquitination. Located in cytoplasm; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 13 | 27066156 | 27171811 | Human | 112 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1317588 | Usp12 | ubiquitin specific peptidase 12 | Enables deubiquitinase activity. Acts upstream of or within protein deubiquitination. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system; gonad; metanephros; and retina layer. Orthologous to human USP1 e='font-weight:700;'>USP12 (ubiquitin specific peptidase 12). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 146671619 | 146731817 | Mouse | 137 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8808749 | Usp12 | ubiquitin specific peptidase 12 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN cytoplasm (ortholog); nucleus (ortholog); plasma membrane (ortholog) | NW_004955497 | 6524487 | 6613403 | Chinchilla | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12012833 | USP12 | ubiquitin specific peptidase 12 | ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | 13 | 8334651 | 8463102 | Bonobo | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12234382 | USP12 | ubiquitin specific peptidase 12 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN cytoplasm (inferred) ; nucleus (inferred); plasma membrane (inferred) | 25 | 12389360 | 12477406 | Dog | 28 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12605466 | Usp12 | ubiquitin specific peptidase 12 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN cytoplasm (inferred) ; cytosol (inferred); nucleus (inferred) | NW_004936472 | 22390418 | 22467690 | Squirrel | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14226557 | USP12 | ubiquitin specific peptidase 12 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN cytoplasm (inferred) ; nucleus (inferred); plasma membrane (inferred) | | | | Pig | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18490407 | USP12 | ubiquitin specific peptidase 12 | ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929676 | Usp12 | ubiquitin specific peptidase 12 | ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN cytoplasm (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235472 | usp12 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626058133 | Usp12 | ubiquitin specific peptidase 12 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN cytoplasm (ortholog); nucleus (ortholog); plasma membrane (ortholog) | | | | Black Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1306044 | Usp13 | ubiquitin specific peptidase 13 | ENCODES a protein that exhibits BAT3 complex binding (ortholog); cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); INVOLVED IN cell population proliferation (ortholog); maintenance of unfolded protein (ortholog); positive regulation of ERAD pathway (o rtholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); skin disease (ortholog); FOUND IN cytoplasm (inferred); INTERACTS WITH (+)-schisandrin B; aconitine; acrylamide | 2 | 117502811 | 117617049 | Rat | 123 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1314436 | USP13 | ubiquitin specific peptidase 13 | Enables several functions, including BAT3 complex binding activity; peptidase activity; and proteasome binding activity. Involved in several processes, including maintenance of unfolded protein; regulation of DNA-templated transcription; and regulation of catabolic process. Acts upstream of or withi n protein deubiquitination and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2025] | 3 | 179653040 | 179789401 | Human | 138 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1552359 | Usp13 | ubiquitin specific peptidase 13 (isopeptidase T-3) | Predicted to enable several functions, including BAT3 complex binding activity; peptidase activity; and proteasome binding activity. Predicted to be involved in several processes, including protein K63-linked deubiquitination; protein stabilization; and regulation of catabolic process. Predicted to act upstream of or within protein K29-linked deubiquitination and protein K6-linked deubiquitination. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human USP13 (ubiquitin specific peptidase 13). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 32870432 | 32992224 | Mouse | 157 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9036988 | Usp13 | ubiquitin specific peptidase 13 | ENCODES a protein that exhibits BAT3 complex binding (ortholog); cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); INVOLVED IN cell population proliferation (ortholog); maintenance of unfolded protein (ortholog); positive regulation of ERAD pathway (o rtholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); skin disease (ortholog) | NW_004955420 | 8835858 | 8919837 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12034422 | USP13 | ubiquitin specific peptidase 13 | ENCODES a protein that exhibits BAT3 complex binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); INVOLVED IN protein K29-linked deubiquitination (ortholog); protein K6-linked deubiquitination (ortholog); protein K63-linked deubiquiti nation (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); skin disease (ortholog); FOUND IN cytoplasm (inferred) | 3 | 176685541 | 176818360 | Bonobo | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12170999 | USP13 | ubiquitin specific peptidase 13 | ENCODES a protein that exhibits BAT3 complex binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); INVOLVED IN protein K29-linked deubiquitination (ortholog); protein K6-linked deubiquitination (ortholog); protein K63-linked deubiquiti nation (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); skin disease (ortholog); FOUND IN cytoplasm (inferred); INTERACTS WITH bisphenol A | 34 | 13059099 | 13175980 | Dog | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12733337 | Usp13 | ubiquitin specific peptidase 13 | ENCODES a protein that exhibits BAT3 complex binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); INVOLVED IN protein K29-linked deubiquitination (ortholog); protein K6-linked deubiquitination (ortholog); protein K63-linked deubiquiti nation (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); skin disease (ortholog); FOUND IN cytoplasm (inferred) | NW_004936566 | 3416468 | 3522127 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14208316 | USP13 | ubiquitin specific peptidase 13 | ENCODES a protein that exhibits BAT3 complex binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); INVOLVED IN protein K29-linked deubiquitination (ortholog); protein K6-linked deubiquitination (ortholog); protein K63-linked deubiquiti nation (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); skin disease (ortholog); FOUND IN cytoplasm (inferred) | | | | Pig | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18736316 | USP13 | ubiquitin specific peptidase 13 | ENCODES a protein that exhibits BAT3 complex binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); INVOLVED IN protein K29-linked deubiquitination (ortholog); protein K6-linked deubiquitination (ortholog); protein K63-linked deubiquiti nation (ortholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); skin disease (ortholog); FOUND IN cytoplasm (inferred) | | | | Green Monkey | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18911481 | Usp13 | ubiquitin specific peptidase 13 | ENCODES a protein that exhibits BAT3 complex binding (ortholog); cysteine-type endopeptidase activity (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN cell population proliferation (ortholog); maintenance of unfolded protein (ortholog); positive regulation of ERAD pathway (orth olog); ASSOCIATED WITH Arsenic Poisoning (ortholog); skin disease (ortholog); FOUND IN cytoplasm (inferred) | | | | Naked Mole-Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259923 | usp13 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625864585 | Usp13 | ubiquitin specific peptidase 13 | ENCODES a protein that exhibits BAT3 complex binding (ortholog); cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); INVOLVED IN cell population proliferation (ortholog); maintenance of unfolded protein (ortholog); positive regulation of ERAD pathway (o rtholog); ASSOCIATED WITH Arsenic Poisoning (ortholog); skin disease (ortholog) | | | | Black Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1311825 | Usp14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); endopeptidase inhibitor activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); inflammatory response (ortholog); negative regulation of ERAD pathway (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog); INTERACTS WITH (+)-schisandrin B; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene | 18 | 1292745 | 1330867 | Rat | 151 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1323483 | USP14 | ubiquitin specific peptidase 14 | This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice wit h a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | 18 | 158557 | 214629 | Human | 157 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1323484 | Usp14 | ubiquitin specific peptidase 14 | Predicted to enable deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Acts upstream of or within chemical synaptic transmission. Located in synapse. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including ali mentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 9993615 | 10030149 | Mouse | 235 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8795140 | Usp14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); endopeptidase inhibitor activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); inflammatory response (ortholog); negative regulation of ERAD pathway (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog) | NW_004955402 | 9710080 | 9737601 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11993211 | USP14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits K63-linked deubiquitinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred) | 18 | 14104754 | 14158402 | Bonobo | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12384300 | USP14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); endopeptidase inhibitor activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); inflammatory response (ortholog); negative regulation of ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog) | 7 | 67035774 | 67080082 | Dog | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12657520 | Usp14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits K63-linked deubiquitinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred) | NW_004936550 | 640331 | 675703 | Squirrel | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14221744 | USP14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits K63-linked deubiquitinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred) | | | | Pig | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14389119 | Usp14 | | | | | | Fly | | symbol | gene, null |
| 18420370 | USP14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits K63-linked deubiquitinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred) | | | | Green Monkey | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18923353 | Usp14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); endopeptidase inhibitor activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); inflammatory response (ortholog); negative regulation of ERAD pathway (ortholog); ASS OCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog) | | | | Naked Mole-Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231810 | usp14 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626062667 | Usp14 | ubiquitin specific peptidase 14 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); endopeptidase inhibitor activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); inflammatory response (ortholog); negative regulation of ERAD pathway (ortholog); ASSOCIATED WITH distal arthrogryposis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 628795 | Usp15 | ubiquitin specific peptidase 15 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination; BMP signaling pathway (ortholog); monoubiquitinated protein deubiquitination (ortholog); PARTICIPATES IN m itochondrial autophagy pathway; ASSOCIATED WITH chronic myeloid leukemia (ortholog); diabetic neuropathy (ortholog); FOUND IN cytoplasm; nucleus; cytosol (ortholog); INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; acrylamide | 7 | 60643611 | 60805137 | Rat | 198 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 733296 | USP15 | ubiquitin specific peptidase 15 | This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 s ignalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011] | 12 | 62260404 | 62416389 | Human | 171 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 733297 | Usp15 | ubiquitin specific peptidase 15 | The protein encoded by this gene is a member of the large ubiquitin specific protease (Usp) family of proteins. These proteins are known to cleave ubiquitin, and contain a conserved cysteine residue (Cys box) and two conserved histidine residues (His box) that are thought to form part of the active site of the protease. This protein has been shown to cleave both the ubiquitin-proline and the ubiquitin-methionine bonds in vitro. This protein is thought to regulate many cellular processes through its deubiquitination activity, including the transforming growth factor beta (TGF-beta) pathway. Cardiac-specific overexpression of the human ortholog of this gene in mice causes enlargement of the heart that is more pronounced in the atrium than in the ventricle. This gene has two pseudogenes on chromosome 14. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms.[provided by RefSeq, Aug 2014] | 10 | 122940911 | 123032924 | Mouse | 221 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8790398 | Usp15 | ubiquitin specific peptidase 15 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); monoubiquitinated protein deubiquitination (ortholog); negative regulation of antifunga l innate immune response (ortholog); PARTICIPATES IN mitochondrial autophagy pathway; ASSOCIATED WITH chronic myeloid leukemia (ortholog); diabetic neuropathy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear body (ortholog) | NW_004955458 | 9440645 | 9533653 | Chinchilla | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12045372 | USP15 | ubiquitin specific peptidase 15 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator (ortholog); PARTICIPATES IN mitochondrial autophagy pathway; ASSOCIATED WITH chronic myeloid leukemia (ortholog); diabetic neuropathy (ortholog); FOUND IN cytoplasm (ortholog) | 12 | 26533441 | 26682964 | Bonobo | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12283650 | USP15 | ubiquitin specific peptidase 15 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator (ortholog); PARTICIPATES IN mitochondrial autophagy pathway; ASSOCIATED WITH chronic myeloid leukemia (ortholog); diabetic neuropathy (ortholog); FOUND IN cytoplasm (ortholog) | 10 | 5510759 | 5634954 | Dog | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12611031 | Usp15 | ubiquitin specific peptidase 15 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator (ortholog); PARTICIPATES IN mitochondrial autophagy pathway; ASSOCIATED WITH chronic myeloid leukemia (ortholog); diabetic neuropathy (ortholog); FOUND IN cytoplasm (ortholog) | NW_004936545 | 978318 | 1094729 | Squirrel | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14252724 | USP15 | ubiquitin specific peptidase 15 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator (ortholog); PARTICIPATES IN mitochondrial autophagy pathway; ASSOCIATED WITH chronic myeloid leukemia (ortholog); diabetic neuropathy (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18658030 | USP15 | ubiquitin specific peptidase 15 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator (ortholog); PARTICIPATES IN mitochondrial autophagy pathway; ASSOCIATED WITH chronic myeloid leukemia (ortholog); diabetic neuropathy (ortholog); FOUND IN cytoplasm (ortholog) | | | | Green Monkey | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918772 | Usp15 | ubiquitin specific peptidase 15 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); monoubiquitinated protein deubiquitination (ortholog); negative regulation of antifunga l innate immune response (ortholog); PARTICIPATES IN mitochondrial autophagy pathway; ASSOCIATED WITH chronic myeloid leukemia (ortholog); diabetic neuropathy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear body (ortholog) | | | | Naked Mole-Rat | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238346 | usp15 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625903470 | Usp15 | ubiquitin specific peptidase 15 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); monoubiquitinated protein deubiquitination (ortholog); negative regulation of antifunga l innate immune response (ortholog); PARTICIPATES IN mitochondrial autophagy pathway; ASSOCIATED WITH chronic myeloid leukemia (ortholog); diabetic neuropathy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear body (ortholog) | | | | Black Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1307192 | Usp16 | ubiquitin specific peptidase 16 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); histone binding (ortholog); INVOLVED IN DNA damage response (ortholog); monoubiquitinated protein deubiquitination (ortholog); positive regulation of DNA-templated trans cription (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH (+)-schisandrin B; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol | 11 | 40166651 | 40196792 | Rat | 149 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1316236 | USP16 | ubiquitin specific peptidase 16 | This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cel l division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | 21 | 29024668 | 29054488 | Human | 120 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1316237 | Usp16 | ubiquitin specific peptidase 16 | Enables histone H2A deubiquitinase activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; nervous sy stem; and sensory organ. Orthologous to human USP16 (ubiquitin specific peptidase 16). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 87251833 | 87280403 | Mouse | 146 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8754875 | Usp16 | ubiquitin specific peptidase 16 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); histone binding (ortholog); INVOLVED IN DNA damage response (ortholog); monoubiquitinated protein deubiquitination (ortholog); positive regulation of DNA-templated trans cription (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; FOUND IN cytoplasm (ortholog); nucleus (ortholog) | NW_004955407 | 28375246 | 28413279 | Chinchilla | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11733723 | USP16 | ubiquitin specific peptidase 16 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); chromatin remodeling (inferred); PARTICIPATES IN at axia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred) | 21 | 15455805 | 15487853 | Bonobo | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12130247 | USP16 | ubiquitin specific peptidase 16 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); chromatin remodeling (inferred); PARTICIPATES IN at axia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; FOUND IN cytoplasm (inferred); nucleus (inferred) | 31 | 24034399 | 24060268 | Dog | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12566167 | Usp16 | ubiquitin specific peptidase 16 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); chromatin remodeling (inferred); PARTICIPATES IN at axia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred) | NW_004936500 | 12963811 | 12989024 | Squirrel | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13926329 | USP16 | ubiquitin specific peptidase 16 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); chromatin remodeling (inferred); PARTICIPATES IN at axia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Pig | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18348456 | USP16 | ubiquitin specific peptidase 16 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN cell division (inferred); chromatin organization (inferred); chromatin remodeling (inferred); PARTICIPATES IN at axia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred) | | | | Green Monkey | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18901676 | Usp16 | ubiquitin specific peptidase 16 | ENCODES a protein that exhibits ribosomal small subunit binding (ortholog); INVOLVED IN DNA damage response (ortholog); monoubiquitinated protein deubiquitination (ortholog); positive regulation of ribosome biogenesis (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233406 | usp16 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625973004 | Usp16 | ubiquitin specific peptidase 16 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); histone binding (ortholog); INVOLVED IN DNA damage response (ortholog); monoubiquitinated protein deubiquitination (ortholog); positive regulation of DNA-templated trans cription (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; FOUND IN cytoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1353279 | USP18 | ubiquitin specific peptidase 18 | The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011] | 22 | 18150170 | 18177397 | Human | 261 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1359153 | Usp18 | ubiquitin specific peptidase 18 | ENCODES a protein that exhibits ISG15-specific peptidase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); negative regulation of type I interferon-mediated signaling pathway (ortholog); regulation of inflammatory response (ortholog) ; ASSOCIATED WITH Acute Lung Injury (ortholog); Aicardi-Goutieres syndrome (ortholog); Chronic Hepatitis C (ortholog); FOUND IN cytosol (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 4 | 156143770 | 156171292 | Rat | 217 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1551994 | Usp18 | ubiquitin specific peptidase 18 | Enables ISG15-specific peptidase activity. Involved in response to stilbenoid. Acts upstream of or within response to bacterium. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol and nucleus. Is expressed in axial skeleton; lung; and mandible. Ort hologous to several human genes including USP18 (ubiquitin specific peptidase 18). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 121222865 | 121247876 | Mouse | 252 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8896359 | Usp18 | ubiquitin specific peptidase 18 | ENCODES a protein that exhibits ISG15-specific peptidase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); negative regulation of type I interferon-mediated signaling pathway (ortholog); regulation of inflammatory response (ortholog) ; ASSOCIATED WITH Acute Lung Injury (ortholog); Aicardi-Goutieres syndrome (ortholog); Chronic Hepatitis C (ortholog); FOUND IN cytosol (ortholog); nucleus (ortholog) | NW_004955454 | 6171575 | 6200879 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12202061 | USP18 | ubiquitin specific peptidase 18 | ENCODES a protein that exhibits molecular adaptor activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); negative regulation of type I interferon-mediated signaling pathway (ortholog); regulation of inflammatory response (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog) ; Aicardi-Goutieres syndrome (ortholog); Chronic Hepatitis C (ortholog); FOUND IN cytosol (ortholog); nucleus (ortholog); INTERACTS WITH bisphenol A | 27 | 45739845 | 45814668 | Dog | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12508534 | Usp18 | ubiquitin specific peptidase 18 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN response to bacterium (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); Aicardi-Goutieres syndrome (ortholog); Chronic Hep atitis C (ortholog); FOUND IN cytosol (inferred); nucleus (inferred) | NW_004936807 | 1090928 | 1116166 | Squirrel | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14113405 | USP18 | ubiquitin specific peptidase 18 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN response to bacterium (ortholog); response to stilbenoid (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); Aicardi-Goutier es syndrome (ortholog); Chronic Hepatitis C (ortholog); FOUND IN cytosol (inferred); nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 35 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18935480 | Usp18 | ubiquitin specific peptidase 18 | ENCODES a protein that exhibits molecular adaptor activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); negative regulation of type I interferon-mediated signaling pathway (ortholog); regulation of inflammatory response (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog) ; Aicardi-Goutieres syndrome (ortholog); Chronic Hepatitis C (ortholog); FOUND IN cytosol (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 151677161 | USP18 | ubiquitin specific peptidase 18 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); molecular adaptor activity (inferred); INVOLVED IN antiviral innate immune response (inferred); negative regulation of type I interferon-mediated signaling pathway (inferred); protein deubiquitination (inferred); FOUND IN cytosol (inferred); nucleus (inferred) | | | | Green Monkey | 12 | symbol | gene, protein-coding |
| 155238762 | usp18 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 329332500 | USP18 | ubiquitin specific peptidase 18 | ENCODES a protein that exhibits ISG15-specific peptidase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); negative regulation of type I interferon-mediated signaling pathway (ortholog); regulation of inflammatory response (ortholog) ; ASSOCIATED WITH Acute Lung Injury (ortholog); Aicardi-Goutieres syndrome (ortholog); Chronic Hepatitis C (ortholog); FOUND IN cytosol (ortholog); nucleus (ortholog) | | | | Bonobo | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 598132578 | USP18 | ubiquitin specific peptidase 18 | ENCODES a protein that exhibits ISG15-specific peptidase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); negative regulation of type I interferon-mediated signaling pathway (ortholog); regulation of inflammatory response (ortholog) ; ASSOCIATED WITH Acute Lung Injury (ortholog); Aicardi-Goutieres syndrome (ortholog); Chronic Hepatitis C (ortholog); FOUND IN cytosol (ortholog); nucleus (ortholog) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625994946 | Usp18 | ubiquitin specific peptidase 18 | ENCODES a protein that exhibits ISG15-specific peptidase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); negative regulation of type I interferon-mediated signaling pathway (ortholog); regulation of inflammatory response (ortholog) ; ASSOCIATED WITH Acute Lung Injury (ortholog); Aicardi-Goutieres syndrome (ortholog); Chronic Hepatitis C (ortholog); FOUND IN cytosol (ortholog); nucleus (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1303276 | Usp19 | ubiquitin specific peptidase 19 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); Hsp90 protein binding (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN positive regulation of cell cycle process; protein deubiquitination; regulation of protein stability; ASSOCIATED WITH general ized epilepsy (ortholog); long QT syndrome (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A | 8 | 118069227 | 118080283 | Rat | 103 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1344113 | USP19 | ubiquitin specific peptidase 19 | Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cy steine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017] | 3 | 49108050 | 49120823 | Human | 92 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551608 | Usp19 | ubiquitin specific peptidase 19 | Enables K48-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of skeletal muscle tissue development; protein K48-linked deubiquitination; and protein stabilization. Locate d in cytosol. Is expressed in ovary and primary sex cord. Orthologous to human USP19 (ubiquitin specific peptidase 19). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 108367806 | 108379536 | Mouse | 104 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8709808 | Usp19 | ubiquitin specific peptidase 19 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); Hsp90 protein binding (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN ERAD pathway (ortholog); negative regulation of proteasomal protein catabolic process (ortholog); negative regulation of skel etal muscle tissue development (ortholog); ASSOCIATED WITH generalized epilepsy (ortholog); long QT syndrome (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum membrane (ortholog) | NW_004955532 | 1104212 | 1115267 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11687839 | USP19 | ubiquitin specific peptidase 19 | ENCODES a protein that exhibits K48-linked deubiquitinase activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN negative regulation of proteasomal protein catabolic process (ortholog); negative regulation of skeletal muscle tissue development (ortholog); positive regulation o f cell cycle process (ortholog); ASSOCIATED WITH generalized epilepsy (ortholog); long QT syndrome (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (inferred); cytoplasm (inferred); cytosol (inferred) | 3 | 49032373 | 49045238 | Bonobo | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12192087 | USP19 | ubiquitin specific peptidase 19 | ENCODES a protein that exhibits K48-linked deubiquitinase activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN negative regulation of proteasomal protein catabolic process (ortholog); negative regulation of skeletal muscle tissue development (ortholog); positive regulation o f cell cycle process (ortholog); ASSOCIATED WITH generalized epilepsy (ortholog); long QT syndrome (ortholog); FOUND IN cytosol (inferred); endoplasmic reticulum membrane (inferred) | 20 | 40062802 | 40074221 | Dog | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12593404 | Usp19 | ubiquitin specific peptidase 19 | ENCODES a protein that exhibits K48-linked deubiquitinase activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN negative regulation of proteasomal protein catabolic process (ortholog); negative regulation of skeletal muscle tissue development (ortholog); positive regulation o f cell cycle process (ortholog); ASSOCIATED WITH generalized epilepsy (ortholog); long QT syndrome (ortholog); FOUND IN cytosol (inferred); endoplasmic reticulum membrane (inferred) | NW_004936529 | 814649 | 826008 | Squirrel | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14040083 | USP19 | ubiquitin specific peptidase 19 | ENCODES a protein that exhibits K48-linked deubiquitinase activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN negative regulation of proteasomal protein catabolic process (ortholog); negative regulation of skeletal muscle tissue development (ortholog); positive regulation o f cell cycle process (ortholog); ASSOCIATED WITH generalized epilepsy (ortholog); long QT syndrome (ortholog); FOUND IN cytosol (inferred); endoplasmic reticulum membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 37 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18545304 | USP19 | ubiquitin specific peptidase 19 | ENCODES a protein that exhibits K48-linked deubiquitinase activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN negative regulation of proteasomal protein catabolic process (ortholog); negative regulation of skeletal muscle tissue development (ortholog); positive regulation o f cell cycle process (ortholog); ASSOCIATED WITH generalized epilepsy (ortholog); long QT syndrome (ortholog); FOUND IN cytosol (inferred); endoplasmic reticulum membrane (inferred) | | | | Green Monkey | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915670 | Usp19 | ubiquitin specific peptidase 19 | ENCODES a protein that exhibits Hsp90 protein binding (ortholog); K48-linked deubiquitinase activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN negative regulation of proteasomal protein catabolic process (ortholog); negative regulation of skeletal muscle tissue development (ortholog); positive regulation of cell cycle process (ortholog); ASSOCIATED WITH generalized epilepsy (ortholog); long QT syndrome (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251441 | usp19 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625857780 | Usp19 | ubiquitin specific peptidase 19 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); Hsp90 protein binding (ortholog); K48-linked deubiquitinase activity (ortholog); INVOLVED IN ERAD pathway (ortholog); negative regulation of proteasomal protein catabolic process (ortholog); negative regulation of skel etal muscle tissue development (ortholog); ASSOCIATED WITH generalized epilepsy (ortholog); long QT syndrome (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Black Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258544 | usp12b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 41272412 | Usp17l | ubiquitin specific peptidase 17 like | | 1 | 168405604 | 168409349 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 155238950 | usp10.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155244840 | usp10.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1348071 | USP10P1 | USP10 pseudogene 1 | | 14 | 19677750 | 19680942 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1604853 | USP10P2 | USP10 pseudogene 2 | | 14 | 18634118 | 18637315 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 38625153 | USP10P3 | USP10 pseudogene 3 | | 22 | 15561175 | 15564363 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 155257729 | usp12.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258948 | usp12.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1561481 | Usp12l1 | ubiquitin specific peptidase 12 like 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); INTERACTS WITH bisphenol A | X | 154601076 | 154604142 | Rat | 13 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1346185 | USP12P1 | USP12 pseudogene 1 | | 5 | 171251643 | 171253966 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 14995390 | USP12P2 | USP12 pseudogene 2 | | 2 | 148295405 | 148296664 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 14995370 | USP12P3 | USP12 pseudogene 3 | | 9 | 67087746 | 67088288 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1351911 | USP12PX | USP12 pseudogene X-linked | INTERACTS WITH lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine | X | 90112475 | 90115029 | Human | 3 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1343926 | USP12PY | USP12 pseudogene Y-linked | INTERACTS WITH lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine | Y | 3682587 | 3685142 | Human | 3 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 155254193 | usp13.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255474 | usp13.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231811 | usp14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249460 | usp14.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155238347 | usp15.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256948 | usp15.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234047 | usp16.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243427 | usp16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 3029324 | USP17L1 | ubiquitin specific peptidase 17 like family member 1 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 7332387 | 7333979 | Human | 21 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, INFERRED [RefSeq] |
| 1605214 | USP17L2 | ubiquitin specific peptidase 17 like family member 2 | Enables cysteine-type deubiquitinase activity. Involved in several processes, including CAAX-box protein processing; protein deubiquitination; and regulation of defense response. Located in endoplasmic reticulum membrane and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 12136435 | 12138849 | Human | 54 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 2312705 | USP17L3 | ubiquitin specific peptidase 17 like family member 3 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 7976393 | 7977985 | Human | 19 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, INFERRED [RefSeq] |
| 2312696 | USP17L4 | ubiquitin specific peptidase 17 like family member 4 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 7337115 | 7338707 | Human | 13 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 2800946 | USP17L5 | ubiquitin specific peptidase 17 like family member 5 | Predicted to enable cysteine-type deubiquitinase activity and lncRNA binding activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to act upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum. P redicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9339403 | 9340995 | Human | 33 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 2312702 | USP17L7 | ubiquitin specific peptidase 17 like family member 7 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 12132417 | 12134099 | Human | 16 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 1588758 | Usp17l8 | ubiquitin specific peptidase 17 like family member 8 | | 1 | 168585112 | 168594783 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 2312703 | USP17L8 | ubiquitin specific peptidase 17 like family member 8 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 7971661 | 7973253 | Human | 13 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, INFERRED [RefSeq] |
| 1620124 | Usp17la | ubiquitin specific peptidase 17-like A | Enables cysteine-type deubiquitinase activity and lncRNA binding activity. Acts upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane and nucleolus. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; exocrine gland; intestine; reproductive system; and thymus. Orthologous to several human genes including USP17L11 (ubiquitin specific peptidase 17 like family member 11); USP17L12 (ubiquitin specific peptidase 17 like family member 12); and USP17L15 (ubiquitin specific peptidase 17 like family member 15). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 104506223 | 104511874 | Mouse | 43 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 41059698 | Usp17la | ubiquitin specific peptidase 17-like A | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); lncRNA binding (ortholog); INVOLVED IN protein deubiquitination (ortholog); INTERACTS WITH 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog); 2,2',5,5'-tetrachlorobi phenyl (ortholog) | 1 | 168577824 | 168581601 | Rat | 16 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1615514 | Usp17lb | ubiquitin specific peptidase 17-like B | Enables cysteine-type deubiquitinase activity. Acts upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including USP1 7L11 (ubiquitin specific peptidase 17 like family member 11); USP17L12 (ubiquitin specific peptidase 17 like family member 12); and USP17L15 (ubiquitin specific peptidase 17 like family member 15). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 104489464 | 104491790 | Mouse | 29 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1614006 | Usp17ld | ubiquitin specific peptidase 17-like D | Enables cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to act upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane and nucleolus. Predicted to be ac tive in cytosol and nucleus. Orthologous to several human genes including USP17L11 (ubiquitin specific peptidase 17 like family member 11); USP17L12 (ubiquitin specific peptidase 17 like family member 12); and USP17L15 (ubiquitin specific peptidase 17 like family member 15). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 102899293 | 102901712 | Mouse | 39 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1621816 | Usp17le | ubiquitin specific peptidase 17-like E | Enables cysteine-type deubiquitinase activity. Acts upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including USP1 7L11 (ubiquitin specific peptidase 17 like family member 11); USP17L12 (ubiquitin specific peptidase 17 like family member 12); and USP17L15 (ubiquitin specific peptidase 17 like family member 15). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 104417168 | 104426677 | Mouse | 46 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 14701027 | Usp17lf | ubiquitin specific peptidase 17-like F | | | | | Mouse | | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding |
| 41094097 | Usp17lh | ubiquitin specific peptidase 17 like H | | 1 | 168570552 | 168574326 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 155238761 | usp18.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236577 | usp18.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251442 | usp19.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255011 | usp19.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14389109 | Usp12-46 | | | | | | Fly | | symbol | gene, null |
| 6481278 | USP12-DT | USP12 divergent transcript | INTERACTS WITH lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine | 13 | 27172259 | 27183503 | Human | 3 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 155258545 | usp12b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259884 | usp12b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14389107 | Usp15-31 | | | | | | Fly | | symbol | gene, null |
| 14389759 | Usp16-45 | | | | | | Fly | | symbol | gene, null |
| 6904251 | USP17L10 | ubiquitin specific peptidase 17 like family member 10 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9210657 | 9212249 | Human | 20 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904258 | USP17L11 | ubiquitin specific peptidase 17 like family member 11 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9215405 | 9216997 | Human | 19 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904255 | USP17L12 | ubiquitin specific peptidase 17 like family member 12 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9220152 | 9221744 | Human | 19 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904261 | USP17L13 | ubiquitin specific peptidase 17 like family member 13 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9224896 | 9226488 | Human | 19 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904328 | USP17L15 | ubiquitin specific peptidase 17 like family member 15 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9234385 | 9236046 | Human | 25 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904267 | USP17L17 | ubiquitin specific peptidase 17 like family member 17 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9243879 | 9245471 | Human | 22 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904270 | USP17L18 | ubiquitin specific peptidase 17 like family member 18 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9248630 | 9250222 | Human | 21 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904287 | USP17L19 | ubiquitin specific peptidase 17 like family member 19 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9253378 | 9254970 | Human | 19 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904284 | USP17L20 | ubiquitin specific peptidase 17 like family member 20 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9258124 | 9259716 | Human | 19 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, PROVISIONAL [RefSeq] |
| 6904281 | USP17L21 | ubiquitin specific peptidase 17 like family member 21 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9262872 | 9264464 | Human | 20 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904427 | USP17L22 | ubiquitin specific peptidase 17 like family member 22 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9267619 | 9269211 | Human | 20 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 15036977 | USP17L23 | ubiquitin specific peptidase 17 like family member 23 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Predicted to be located in endoplasmic reticulum and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | | | | Human | 7 | symbol , COSMIC , Human Proteome Map | gene, protein-coding |
| 6904303 | USP17L24 | ubiquitin specific peptidase 17 like family member 24 | Enables RNA binding activity; cysteine-type deubiquitinase activity; and hyaluronic acid binding activity. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by A lliance of Genome Resources, Jul 2025] | 4 | 9325165 | 9326757 | Human | 29 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, INFERRED [RefSeq] |
| 6904300 | USP17L25 | ubiquitin specific peptidase 17 like family member 25 | Enables RNA binding activity; cysteine-type deubiquitinase activity; and hyaluronic acid binding activity. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by A lliance of Genome Resources, Jul 2025] | 4 | 9329911 | 9331503 | Human | 31 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904297 | USP17L26 | ubiquitin specific peptidase 17 like family member 26 | Enables RNA binding activity; cysteine-type deubiquitinase activity; and hyaluronic acid binding activity. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by A lliance of Genome Resources, Jul 2025] | 4 | 9334658 | 9336250 | Human | 29 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904294 | USP17L27 | ubiquitin specific peptidase 17 like family member 27 | Enables RNA binding activity; cysteine-type deubiquitinase activity; and hyaluronic acid binding activity. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by A lliance of Genome Resources, Jul 2025] | 4 | 9344148 | 9345740 | Human | 29 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904277 | USP17L28 | ubiquitin specific peptidase 17 like family member 28 | Enables RNA binding activity; cysteine-type deubiquitinase activity; and hyaluronic acid binding activity. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by A lliance of Genome Resources, Jul 2025] | 4 | 9348893 | 9350485 | Human | 29 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904274 | USP17L29 | ubiquitin specific peptidase 17 like family member 29 | Enables RNA binding activity; cysteine-type deubiquitinase activity; and hyaluronic acid binding activity. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by A lliance of Genome Resources, Jul 2025] | 4 | 9353638 | 9355230 | Human | 27 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 6904290 | USP17L30 | ubiquitin specific peptidase 17 like family member 30 | Enables RNA binding activity; cysteine-type deubiquitinase activity; and hyaluronic acid binding activity. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by A lliance of Genome Resources, Jul 2025] | 4 | 9363129 | 9364721 | Human | 30 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, INFERRED [RefSeq] |
| 2793512 | USP17L6P | ubiquitin specific peptidase 17 like family member 6, pseudogene | Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 9367874 | 9369070 | Human | 42 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |
| 1349777 | USP17L9P | ubiquitin specific peptidase 17 like family member 9, pseudogene | INTERACTS WITH butanal; cadmium atom; copper(II) sulfate | 4 | 9358382 | 9359974 | Human | 5 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |
| 6500127 | Usp17la2 | ubiquitin specific peptidase 17-like a2 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN CAAX-box protein processing (ortholog); negative regulation of GTPase activity (ortholog); negative regulation of protein processing (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); nucleus ( ortholog); INTERACTS WITH Cuprizon; 2-hydroxypropanoic acid (ortholog); benzo[a]pyrene (ortholog) | 1 | 168563281 | 168567056 | Rat | 30 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 6481274 | USP12-AS1 | USP12 antisense RNA 1 | INTERACTS WITH aflatoxin B1 | 13 | 27125533 | 27169135 | Human | 1 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1596203 | Usp12-ps1 | ubiquitin specific peptidase 12, pseudogene 1 | | 7 | 3591275 | 3592504 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 6499070 | Usp15-ps1 | ubiquitin specific peptidase 15, pseudogene 1 | | 7 | 7543621 | 7544603 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41215575 | Usp15-ps2 | ubiquitin specific peptidase 15, pseudogene 2 | | 5 | 118675654 | 118680932 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 6904264 | USP17L14P | ubiquitin specific peptidase 17 like family member 14, pseudogene | | 4 | 9229641 | 9231233 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6904265 | USP17L16P | ubiquitin specific peptidase 17 like family member 16, pseudogene | | 4 | 9239232 | 9240254 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1619619 | Usp17le-ps | ubiquitin specific peptidase 17-like E, pseudogene | INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine | 7 | 104296456 | 104302361 | Mouse | 1 | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1349681 | USP21 | ubiquitin specific peptidase 21 | This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquiti n-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] | 1 | 161159500 | 161165723 | Human | 88 | description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1615930 | Usp21 | ubiquitin specific peptidase 21 | Enables cysteine-type deubiquitinase activity and transcription coactivator activity. Involved in transcription initiation-coupled chromatin remodeling. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in left lung; primary oocyt e; right lung; and submandibular gland primordium. Orthologous to human USP21 (ubiquitin specific peptidase 21). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 171109523 | 171115534 | Mouse | 103 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1315395 | USP32 | ubiquitin specific peptidase 32 | Enables cysteine-type deubiquitinase activity. Involved in positive regulation of TORC1 signaling. Located in cytosol. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 60177327 | 60422416 | Human | 85 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1604943 | USP41P | ubiquitin specific peptidase 41, pseudogene | INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; 4,4'-sulfonyldiphenol; all-trans-retinoic acid | 22 | 20363616 | 20377260 | Human | 12 | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1594092 | Hrgl1 | histidine-rich glycoprotein like 1 | ENCODES a protein that exhibits heme binding (ortholog); heparan sulfate proteoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN defense response to fungus (ortholog); negative regulation of angiogenesis (ortholog); negative regulation of blood vessel endothelial cell migration (ort holog); FOUND IN extracellular region (inferred) | 11 | 91543964 | 91553946 | Rat | 50 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8774134 | LOC102020743 | ubiquitin carboxyl-terminal hydrolase 17 | | NW_004955403 | 53540579 | 53541734 | Chinchilla | | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8876659 | LOC102016277 | ubiquitin carboxyl-terminal hydrolase 17-like protein 6 | | NW_004955487 | 138278 | 141472 | Chinchilla | | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1345113 | LINC00161 | long intergenic non-protein coding RNA 161 | INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; aflatoxin B1; benzo[a]pyrene | 21 | 28539318 | 28540355 | Human | 7 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 12386107 | CDK16 | cyclin dependent kinase 16 | ENCODES a protein that exhibits ATP binding (inferred); cyclin-dependent protein serine/threonine kinase activity (inferred); cysteine-type deubiquitinase activity (inferred); INVOLVED IN exocytosis (ortholog); growth hormone secretion (ortholog); neuron projection development (ortholog); ASSOCIATED WITH Asthenozoospermia (ortholog); oligospermia (ortholog); Teratozoospermia (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); plasma membrane (ortholog); synaptic vesicle (ortholog) | X | 40810107 | 40822130 | Dog | 59 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12044085 | QARS1 | glutaminyl-tRNA synthetase 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein kinase inhibitor activity (ortholog); INVOLVED IN brain development (ortholog); negative regulation of apoptotic signaling pathway (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN 2-h ydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); autosomal dominant intellectual developmental disorder 43 (ortholog); epilepsy (ortholog); FOUND IN protein-containing complex (ortholog) | 3 | 49020310 | 49029443 | Bonobo | 49 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1317441 | USP30 | ubiquitin specific peptidase 30 | USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008] | 12 | 109023089 | 109088023 | Human | 84 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 16566772 | AF129075.2 | novel transcript, antisense to USP16 | | | | | Human | | name | gene, lncrna |
| 16560639 | AC130365.1 | ubiquitin specific peptidase 17 (USP17) pseudogene | | 8 | 7967344 | 7968544 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16561465 | AL512310.7 | ubiquitin specific peptidase 10 (USP10) pseudogene | | | | | Human | | name | gene, transcribed_processed_pseudogene |
| 16552194 | AP000533.2 | ubiquitin specific peptidase 10 (USP10) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16561219 | CR383656.1 | ubiquitin specific peptidase 10 (USP10) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16560824 | AC087203.2 | ubiquitin specific peptidase 17-like 2 (USP17L2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16560232 | AC087203.1 | ubiquitin specific peptidase 17-like 2 ( USP17L2) pseudogene | | 8 | 12374354 | 12375546 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 1619991 | Ggnbp1 | gametogenetin binding protein 1 | Involved in mitochondrial fission. Located in Golgi apparatus; mitochondrial intermembrane space; and plasma membrane. Is expressed in ductus deferens; epididymis; jejunum; and testis. Orthologous to human GGNBP1 (gametogenetin binding protein 1 (pseudogene)). [provided by Alliance of Genome Resourc es, Jul 2025] | 17 | 27237009 | 27255352 | Mouse | 53 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1315150 | WDR20 | WD repeat domain 20 | This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 20 11] | 14 | 102139423 | 102224839 | Human | 69 | description | gene, protein-coding, REVIEWED [RefSeq] |