Usp17la (ubiquitin specific peptidase 17-like A) - Rat Genome Database

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Gene: Usp17la (ubiquitin specific peptidase 17-like A) Rattus norvegicus
Analyze
Symbol: Usp17la
Name: ubiquitin specific peptidase 17-like A
RGD ID: 41059698
Description: Predicted to enable cysteine-type deubiquitinase activity and lncRNA binding activity. Predicted to act upstream of or within protein deubiquitination; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog); 2,2',5,5'-tetrachlorobiphenyl (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC120098474; ubiquitin carboxyl-terminal hydrolase 17-like protein D
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81168,577,824 - 168,581,601 (+)NCBIGRCr8
mRatBN7.21159,165,961 - 159,169,738 (+)NCBImRatBN7.2mRatBN7.2
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp17laRat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOUsp17la (Mus musculus)6480464[2 more ...CTDPMID:25510870
Usp17laRat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOUsp17la (Mus musculus)6480464[2 more ...CTDPMID:25510870
Usp17laRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOUsp17la (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of USP17L5 mRNACTDPMID:21570461
Usp17laRat2,4-diaminotoluene decreases expressionISOUsp17la (Mus musculus)64804642 and 4-diaminotoluene results in decreased expression of USP17LA mRNACTDPMID:20713471
Usp17laRat3-methylcholanthrene affects expressionISOUsp17la (Mus musculus)6480464Methylcholanthrene affects the expression of USP17LA mRNACTDPMID:20713471
Usp17laRatbenzo[a]pyrene decreases expressionISOUsp17la (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of USP17LA mRNACTDPMID:20713471
Usp17laRatbis(2-ethylhexyl) phthalate decreases expressionISOUsp17la (Mus musculus)6480464Diethylhexyl Phthalate results in decreased expression of USP17LA mRNACTDPMID:34319233
Usp17laRatbisphenol A increases methylationISOUsp17la (Mus musculus)6480464bisphenol A results in increased methylation of USP17LA promoterCTDPMID:27312807
Usp17laRatmethyl methacrylate increases expressionISOUsp17la (Mus musculus)6480464Methylmethacrylate results in increased expression of USP17L5 mRNA and Methylmethacrylate results in increased expression of USP17LA mRNACTDPMID:16916219
Usp17laRatPCB138 multiple interactionsISOUsp17la (Mus musculus)6480464[2 more ...CTDPMID:25510870
Usp17laRattert-butyl hydroperoxide increases expressionISOUsp17la (Mus musculus)6480464tert-Butylhydroperoxide results in increased expression of USP17LA mRNACTDPMID:14729362 and PMID:15003993
Usp17laRattriptonide increases expressionISOUsp17la (Mus musculus)6480464triptonide results in increased expression of USP17LA mRNACTDPMID:33045310

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp17laRatprotein deubiquitination acts_upstream_of_or_withinISOUsp17la (Mus musculus)1624291 PMID:8622927RGDPMID:8622927
Usp17laRatprotein deubiquitination involved_inIEAInterPro:IPR0013941600115GO_REF:0000002InterProGO_REF:0000002
Usp17laRatprotein deubiquitination involved_inIEAARBA:ARBA000278791600115GO_REF:0000117UniProtGO_REF:0000117
Usp17laRatproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Usp17laRatregulation of apoptotic process involved_inIBAFB:FBgn0260936 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp17laRatregulation of protein stability involved_inIBAFB:FBgn0016756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp17laRatcytosol is_active_inIBAFB:FBgn0016756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp17laRatnucleus is_active_inIBAFB:FBgn0016756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp17laRatcysteine-type deubiquitinase activity enablesIEAARBA:ARBA000268801600115GO_REF:0000117UniProtGO_REF:0000117
Usp17laRatcysteine-type deubiquitinase activity enablesIEAInterPro:IPR001394 and InterPro:IPR0182001600115GO_REF:0000002InterProGO_REF:0000002
Usp17laRatcysteine-type deubiquitinase activity enablesISOUsp17la (Mus musculus)1624291 PMID:8622927RGDPMID:8622927
Usp17laRatcysteine-type deubiquitinase activity enablesIEAUniRule:UR0008807561600115GO_REF:0000104UniProtGO_REF:0000104
Usp17laRatcysteine-type deubiquitinase activity enablesIBAFB:FBgn0005632 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp17laRatcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Usp17laRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Usp17laRatlncRNA binding enablesISOUsp17la (Mus musculus)1624291 PMID:31674275RGDPMID:31674275
Usp17laRatpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
1 to 9 of 9 rows


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.


Usp17la
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81168,577,824 - 168,581,601 (+)NCBIGRCr8
mRatBN7.21159,165,961 - 159,169,738 (+)NCBImRatBN7.2mRatBN7.2
Cytogenetic Map1q32NCBI
Usp17la
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397104,506,223 - 104,511,874 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7104,506,216 - 104,511,874 (+)EnsemblGRCm39 Ensembl
GRCm387104,857,016 - 104,862,667 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7104,857,009 - 104,862,667 (+)EnsemblGRCm38mm10GRCm38
MGSCv377112,005,530 - 112,011,181 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367104,730,837 - 104,736,488 (+)NCBIMGSCv36mm8
Celera7105,132,029 - 105,137,801 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map755.69NCBI

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1 to 10 of 78 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat

1 to 10 of 78 rows





RefSeq Transcripts XM_039097849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_039097849   ⟹   XP_038953777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,577,824 - 168,581,601 (+)NCBI
mRatBN7.21159,165,961 - 159,169,738 (+)NCBI
Protein RefSeqs XP_038953777 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095262.1
RefSeq Acc Id: XP_038953777   ⟸   XM_039097849
- UniProtKB: A0A8I6AMA7 (UniProtKB/TrEMBL)
USP


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 20 of 20 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58066 BioCyc
Ensembl Genes ENSRNOG00000066547 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000112361.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Peptidase_C19 UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/TrEMBL
  USP_CS UniProtKB/TrEMBL
  USP_dom UniProtKB/TrEMBL
NCBI Gene LOC120098474 ENTREZGENE
PANTHER INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 7-RELATED UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
Pfam UCH UniProtKB/TrEMBL
PhenoGen Usp17la PhenoGen
PROSITE USP_1 UniProtKB/TrEMBL
  USP_2 UniProtKB/TrEMBL
  USP_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000066547 RatGTEx
Superfamily-SCOP Cysteine proteinases UniProtKB/TrEMBL
UniProt A0A8I6AMA7 ENTREZGENE, UniProtKB/TrEMBL
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-10 Usp17la  ubiquitin specific peptidase 17-like A  LOC120098474  ubiquitin carboxyl-terminal hydrolase 17-like protein D  Name and Symbol changed 629549 APPROVED
2021-01-27 LOC120098474  ubiquitin carboxyl-terminal hydrolase 17-like protein D      Symbol and Name status set to provisional 70820 PROVISIONAL