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Gene: USP16 (ubiquitin specific peptidase 16) Homo sapiens
Symbol: USP16
Name: ubiquitin specific peptidase 16
RGD ID: 1316236
Description: Exhibits several functions, including peptidase activity; transcription coactivator activity; and zinc ion binding activity. Involved in several processes, including histone H2A K63-linked deubiquitination; positive regulation of macromolecule biosynthetic process; and protein homotetramerization. Localizes to nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: deubiquitinating enzyme 16; ubiquitin carboxyl-terminal hydrolase 16; ubiquitin specific protease 16; ubiquitin thioesterase 16; ubiquitin thiolesterase 16; ubiquitin-processing protease UBP-M; ubiquitin-specific processing protease 16; ubiquitin-specific-processing protease 16; UBP-M; UBPM
Mus musculus (house mouse) : Usp16 (ubiquitin specific peptidase 16)  MGI  Alliance
Rattus norvegicus (Norway rat) : Usp16 (ubiquitin specific peptidase 16)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp16 (ubiquitin specific peptidase 16)
Pan paniscus (bonobo/pygmy chimpanzee) : USP16 (ubiquitin specific peptidase 16)
Canis lupus familiaris (dog) : USP16 (ubiquitin specific peptidase 16)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp16 (ubiquitin specific peptidase 16)
Sus scrofa (pig) : USP16 (ubiquitin specific peptidase 16)
Chlorocebus sabaeus (African green monkey) : USP16 (ubiquitin specific peptidase 16)
Heterocephalus glaber (naked mole-rat) : Usp16 (ubiquitin specific peptidase 16)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2129,024,629 - 29,054,488 (+)EnsemblGRCh38hg38GRCh38
GRCh382129,024,651 - 29,054,488 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372130,396,938 - 30,426,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362129,318,809 - 29,348,680 (+)NCBINCBI36hg18NCBI36
Build 342129,318,808 - 29,348,676NCBI
Celera2115,580,416 - 15,610,282 (+)NCBI
Cytogenetic Map21q21.3NCBI
HuRef2115,803,158 - 15,833,022 (+)NCBIHuRef
CHM1_12129,959,294 - 29,989,158 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on USP16
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316236
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.