RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: urethral obstruction
Accession: DOID:12577
browse the term
Definition: Partial or complete blockage in any part of the URETHRA that can lead to difficulty or inability to empty the URINARY BLADDER. It is characterized by an enlarged, often damaged, bladder with frequent urges to void.
Synonyms: exact_synonym: obstruction of urethra; urethral obstructions
primary_id: MESH:D014524
xref: NCI:C79804
For additional species annotation, visit the
Alliance of Genome Resources .
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
ISO
RGD
PMID:12050560
RGD:7257713
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Gja1
gap junction protein, alpha 1
IEP
mRNA,protein:increased expression:smooth muscle cell:
RGD
PMID:11900482
RGD:11568666
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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Gjb2
gap junction protein, beta 2
IEP
mRNA,protein:increased expression:urothelium:
RGD
PMID:11900482
RGD:11568666
NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
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Mapk1
mitogen activated protein kinase 1
IEP
RGD
PMID:23698112
RGD:7244171
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Nos1
nitric oxide synthase 1
IEP
protein:increased expression:urinary bladder
RGD
PMID:23766828
RGD:7257604
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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Tgfb1
transforming growth factor, beta 1
treatment
IEP
RGD
PMID:24066596
RGD:7394856
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Adra1a
adrenoceptor alpha 1A
IMP
RGD
PMID:20886573
RGD:5688368
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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Col1a1
collagen type I alpha 1 chain
treatment
IEP
RGD
PMID:23313213
RGD:7257549
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col3a1
collagen type III alpha 1 chain
treatment
IEP
RGD
PMID:23313213
RGD:7257549
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
ISO
RGD
PMID:21356374
RGD:7257709
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Eln
elastin
treatment
IEP
RGD
PMID:23313213
RGD:7257549
NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
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Hif1a
hypoxia inducible factor 1 subunit alpha
IEP
protein:increased expression:urinary bladder (rat)
RGD
PMID:12118092
RGD:9068887
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Htr2a
5-hydroxytryptamine receptor 2A
IEP
mRNA:increased expression:urinary bladder
RGD
PMID:23344575
RGD:7257660
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Mmp7
matrix metallopeptidase 7
treatment
IEP
RGD
PMID:23313213
RGD:7257549
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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Ngf
nerve growth factor
treatment
IDA
RGD
PMID:22795377
RGD:7242774
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Nos3
nitric oxide synthase 3
IEP
mRNA:decreased expression:urinary bladder
RGD
PMID:21256554
RGD:4891960
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Optn
optineurin
IEP
protein:increased expression:urinary bladder:
RGD
PMID:16361812
RGD:7775024
NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15311063
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Sod2
superoxide dismutase 2
IEP
RGD
PMID:21060756
RGD:7175518
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Bnc2
basonuclin zinc finger protein 2
ISO
ClinVar Annotator: match by term: Lower urinary tract obstruction, congenital
OMIM ClinVar
PMID:25741868 PMID:28492532 PMID:31051115
NCBI chr 5:98,679,071...99,016,044
Ensembl chr 5:98,687,410...99,079,426
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Ppic
peptidylprolyl isomerase C
ISO
ClinVar Annotator: match by term: Lower urinary tract obstruction, congenital
ClinVar
PMID:31690835
NCBI chr18:46,842,410...46,855,016
Ensembl chr18:46,842,409...46,855,017
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Prdm6
PR/SET domain 6
ISO
ClinVar Annotator: match by term: Lower urinary tract obstruction, congenital
ClinVar
PMID:31690835
NCBI chr18:46,904,115...47,008,482
Ensembl chr18:46,904,127...47,007,823
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Sncaip
synuclein, alpha interacting protein
ISO
ClinVar Annotator: match by term: Lower urinary tract obstruction, congenital
ClinVar
PMID:31690835
NCBI chr18:46,205,846...46,343,932
Ensembl chr18:46,207,152...46,343,929
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Snx2
sorting nexin 2
ISO
ClinVar Annotator: match by term: Lower urinary tract obstruction, congenital
ClinVar
PMID:31690835
NCBI chr18:46,602,223...46,643,870
Ensembl chr18:46,602,284...46,643,865
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Snx24
sorting nexin 24
ISO
ClinVar Annotator: match by term: Lower urinary tract obstruction, congenital
ClinVar
PMID:31690835
NCBI chr18:46,670,987...46,826,070
Ensembl chr18:46,671,443...46,826,068
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