PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: acetylsalicylic acid pharmacodynamics pathway
Accession: PW:0001615
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Definition: The actual targets of acetylsalicylic acid known as aspirin were discovered after the drug was marketed. It was believed that it acts upon the central nervous system, but its true mode of action is to irreversibly inhibit cuclooxygenase enzyme COX-1 and to a lesser extent COX-2, thus suppressing the downstream production of prostaglandins and thromboxanes. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms: related_synonym: SMP:00083; aspirin pharmacodynamics pathway
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Akr1c3
aldo-keto reductase family 1, member C3
ISO
SMPDB
SMP:00083
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Alox12
arachidonate 12-lipoxygenase, 12S type
ISO
SMPDB
SMP:00083
NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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Alox12b
arachidonate 12-lipoxygenase, 12R type
ISO
SMPDB
SMP:00083
NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938
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Alox15
arachidonate 15-lipoxygenase
ISO
SMPDB
SMP:00083
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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Alox15b
arachidonate 15-lipoxygenase, type B
ISO
SMPDB
SMP:00083
NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812
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Alox5
arachidonate 5-lipoxygenase
ISO
SMPDB
SMP:00083
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Cbr1
carbonyl reductase 1
ISO
SMPDB
SMP:00083
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
ISO
SMPDB
SMP:00083
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
ISO
SMPDB
SMP:00083
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
ISO
SMPDB
SMP:00083
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
ISO
SMPDB
SMP:00083
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp2u1
cytochrome P450, family 2, subfamily u, polypeptide 1
ISO
SMPDB
SMP:00083
NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882
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Cyp4f18
cytochrome P450, family 4, subfamily f, polypeptide 18
ISO
SMPDB
SMP:00083
NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940
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Cyp4f6
cytochrome P450, family 4, subfamily f, polypeptide 6
ISO
SMPDB
SMP:00083
NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
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Ephx2
epoxide hydrolase 2
ISO
SMPDB
SMP:00083
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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Ggt1
gamma-glutamyltransferase 1
ISO
SMPDB
SMP:00083
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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Gpx1
glutathione peroxidase 1
ISO
SMPDB
SMP:00083
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Lta4h
leukotriene A4 hydrolase
ISO
SMPDB
SMP:00083
NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
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Ltc4s
leukotriene C4 synthase
ISO
SMPDB
SMP:00083
NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
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Pla2g4b
phospholipase A2 group IVB
ISO
SMPDB
SMP:00083
NCBI chr 3:107,004,238...107,013,853
Ensembl chr 3:107,005,489...107,013,853
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Prxl2b
peroxiredoxin like 2B
ISO
SMPDB
SMP:00083
NCBI chr 5:165,462,610...165,465,213
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Ptgds
prostaglandin D2 synthase
ISO
SMPDB
SMP:00083
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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Ptges
prostaglandin E synthase
ISO
SMPDB
SMP:00083
NCBI chr 3:14,177,892...14,189,236
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Ptgis
prostaglandin I2 synthase
ISO
SMPDB
SMP:00083
NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
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Ptgs1
prostaglandin-endoperoxide synthase 1
ISO
SMPDB
SMP:00083
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
SMPDB
SMP:00083
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Tbxas1
thromboxane A synthase 1
ISO
SMPDB
SMP:00083
NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all