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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of antigen receptor-mediated signaling pathway
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Accession:GO:0050858 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
Synonyms:exact_synonym: down regulation of antigen receptor-mediated signaling pathway;   downregulation of antigen receptor-mediated signaling pathway;   negative regulation of antigen receptor mediated signalling pathway
 narrow_synonym: inhibition of antigen receptor-mediated signaling pathway


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negative regulation of B cell receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd22 CD22 molecule ISO
IBA
(PMID:24169826), (PMID:26017478)
PMID:21873635
RGD PMID:24169826, PMID:26017478, PMID:21873635 RGD:13792537 NCBI chr 1:89,313,475...89,329,902
Ensembl chr 1:89,314,558...89,329,418
JBrowse link
G Cd300a Cd300a molecule ISO (PMID:21482706) RGD PMID:21482706 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb ISO (PMID:24169826) RGD PMID:24169826 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Fcrl5 Fc receptor-like 5 ISO MGI:MGI:96055|MGI:MGI:96892 (MGI:MGI:5471851|PMID:23509253) RGD PMID:23509253 MGI:MGI:5471851 NCBI chr 2:186,776,466...186,797,900
Ensembl chr 2:186,776,605...186,808,078
JBrowse link
G Gps2 G protein pathway suppressor 2 ISO (MGI:MGI:5896692|PMID:28039360) RGD PMID:28039360 MGI:MGI:5896692 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Lpxn leupaxin ISO
IBA
(PMID:17640867)
PMID:21873635
(MGI:MGI:3722965|PMID:17640867)
RGD PMID:17640867, PMID:21873635 MGI:MGI:3722965, RGD:13792537 NCBI chr 1:229,642,437...229,674,129
Ensembl chr 1:229,642,412...229,674,134
JBrowse link
G Plcl2 phospholipase C-like 2 ISO MGI:MGI:2679632 (MGI:MGI:2677607|PMID:14517301) RGD PMID:14517301 MGI:MGI:2677607 NCBI chr 9:1,782,536...1,984,654
Ensembl chr 9:1,782,536...1,984,654
JBrowse link
negative regulation of T cell receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07035561.2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr12:19,680,712...19,681,832 JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 ISO (MGI:MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:MGI:5520006 NCBI chr17:43,867,243...43,878,734
Ensembl chr17:43,868,191...43,879,839
JBrowse link
G Btnl2 butyrophilin-like 2 ISO
IEA
(MGI:MGI:3775536|PMID:16751379)
GO_REF:0000107
RGD
Ensembl
PMID:16751379 GO_REF:0000107, MGI:MGI:3775536 NCBI chr20:4,140,184...4,156,365
Ensembl chr20:4,141,878...4,154,978
JBrowse link
G Cblb Cbl proto-oncogene B ISO MGI:MGI:2180572 (MGI:MGI:3041371|PMID:14738763) RGD PMID:14738763 MGI:MGI:3041371 NCBI chr11:51,037,383...51,202,761
Ensembl chr11:51,037,393...51,202,820
JBrowse link
G Cd160 CD160 molecule ISO (PMID:18193050) RGD PMID:18193050 NCBI chr 2:198,933,681...198,965,380
Ensembl chr 2:198,935,133...198,942,732
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 ISO
ISS
(PMID:18424730)
GO_REF:0000024
RGD
UniProt
PMID:18424730 GO_REF:0000024 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Dgkz diacylglycerol kinase zeta ISS
ISO
GO_REF:0000024
(MGI:MGI:2672999|PMID:12883552)
UniProt
RGD
PMID:12883552 GO_REF:0000024, MGI:MGI:2672999 NCBI chr 3:80,844,002...80,886,487
Ensembl chr 3:80,844,005...80,875,817
JBrowse link
G Dusp22 dual specificity phosphatase 22 ISO (MGI:MGI:5583944|PMID:24714587) RGD PMID:24714587 MGI:MGI:5583944 NCBI chr17:34,986,589...35,037,297
Ensembl chr17:34,986,591...35,037,076
JBrowse link
G Dusp3 dual specificity phosphatase 3 ISO
IBA
(PMID:12447358)
PMID:21873635
RGD PMID:12447358, PMID:21873635 RGD:13792537 NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
JBrowse link
G Elf1 E74 like ETS transcription factor 1 ISO MGI:MGI:1926074 (MGI:MGI:3041371|PMID:14738763) RGD PMID:14738763 MGI:MGI:3041371 NCBI chr15:61,772,544...61,868,442
Ensembl chr15:61,826,711...61,868,343
JBrowse link
G Ezr ezrin ISO (PMID:20551903) RGD PMID:20551903 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Gbp1 guanylate binding protein 1 ISO (PMID:24337748) RGD PMID:24337748 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Lgals3 galectin 3 ISO (MGI:MGI:4355752|PMID:19706535) RGD PMID:19706535 MGI:MGI:4355752 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 ISO (PMID:22387553) RGD PMID:22387553 NCBI chr 1:73,393,854...73,399,448
Ensembl chr 1:73,393,850...73,399,579
JBrowse link
G Pawr pro-apoptotic WT1 regulator ISO
IEA
MGI:MGI:2678021 (MGI:MGI:2675524|PMID:12970181)
GO_REF:0000107
RGD
Ensembl
PMID:12970181 GO_REF:0000107, MGI:MGI:2675524 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Phpt1 phosphohistidine phosphatase 1 ISO (PMID:18796614) RGD PMID:18796614 NCBI chr 3:2,797,037...2,798,436
Ensembl chr 3:2,796,997...2,798,470
JBrowse link
G Prnp prion protein ISO (MGI:MGI:4943618|PMID:20145049) RGD PMID:20145049 MGI:MGI:4943618 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(MGI:MGI:5320871|PMID:22080863)
GO_REF:0000024
RGD
UniProt
PMID:22080863 GO_REF:0000024, MGI:MGI:5320871 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO (PMID:18056643) RGD PMID:18056643 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO
IEA
MGI:MGI:1856074 (MGI:MGI:82729|PMID:9064344)
GO_REF:0000107
RGD
Ensembl
PMID:9064344 GO_REF:0000107, MGI:MGI:82729 NCBI chr 4:157,239,141...157,263,890
Ensembl chr 4:157,239,142...157,263,890
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J ISO (MGI:MGI:4942249|PMID:12913111)
(PMID:11259588), (PMID:12913111), (PMID:9780142)
RGD PMID:9780142, PMID:11259588, PMID:12913111 MGI:MGI:4942249 NCBI chr 3:79,233,519...79,390,956
Ensembl chr 3:79,233,525...79,390,956
JBrowse link
G Pvrig PVR related immunoglobulin domain containing ISO (PMID:26755705) RGD PMID:26755705 NCBI chr12:19,679,671...19,681,861 JBrowse link
G Sh2d1a SH2 domain containing 1A ISO
IEA
(PMID:9774102)
GO_REF:0000107
RGD
Ensembl
PMID:9774102 GO_REF:0000107 NCBI chr  X:128,897,053...128,925,408
Ensembl chr  X:128,897,181...128,925,407
JBrowse link
G Sla2 Src-like-adaptor 2 ISO (PMID:11891219) RGD PMID:11891219 NCBI chr 3:152,942,838...153,004,047
Ensembl chr 3:152,944,452...153,001,309
JBrowse link
G Thy1 Thy-1 cell surface antigen ISO
ISS
(MGI:MGI:1096761|PMID:9285719)
GO_REF:0000024
RGD
UniProt
PMID:9285719 GO_REF:0000024, MGI:MGI:1096761 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing, A ISO
IBA
MGI:MGI:107180 (MGI:MGI:3041371|PMID:14738763)
PMID:21873635
RGD PMID:14738763, PMID:21873635 MGI:MGI:3041371, RGD:13792537 NCBI chr20:9,941,102...9,986,012
Ensembl chr20:9,948,908...9,985,133
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    immune system process 2838
      negative regulation of immune system process 479
        negative regulation of antigen receptor-mediated signaling pathway 33
          negative regulation of B cell receptor signaling pathway 7
          negative regulation of T cell receptor signaling pathway + 26
Path 2
Term Annotations click to browse term
  biological_process 20015
    biological regulation 13760
      regulation of biological process 13073
        regulation of immune system process 1505
          positive regulation of immune system process 1061
            positive regulation of immune response 671
              activation of immune response 417
                immune response-activating signal transduction 318
                  immune response-activating cell surface receptor signaling pathway 317
                    antigen receptor-mediated signaling pathway 283
                      regulation of antigen receptor-mediated signaling pathway 64
                        negative regulation of antigen receptor-mediated signaling pathway 33
                          negative regulation of B cell receptor signaling pathway 7
                          negative regulation of T cell receptor signaling pathway + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.