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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of antigen receptor-mediated signaling pathway
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Accession:GO:0050858 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
Synonyms:exact_synonym: down regulation of antigen receptor-mediated signaling pathway;   downregulation of antigen receptor-mediated signaling pathway;   negative regulation of antigen receptor mediated signalling pathway
 narrow_synonym: inhibition of antigen receptor-mediated signaling pathway


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negative regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd22 CD22 molecule involved_in IBA
ISO
PMID:21873635
(PMID:24169826), (PMID:26017478)
RGD PMID:24169826 PMID:26017478 PMID:21873635 RGD:13792537 NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322
JBrowse link
G Cd300a Cd300a molecule involved_in ISO (PMID:21482706) RGD PMID:21482706 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb involved_in ISO (PMID:24169826) RGD PMID:24169826 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Fcrl5 Fc receptor-like 5 acts_upstream_of_or_within ISO MGI:96055|MGI:96892 (MGI:5471851|PMID:23509253) RGD PMID:23509253 MGI:5471851 NCBI chr 2:172,881,763...172,912,912
Ensembl chr 2:172,881,448...172,913,148
JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:5896692|PMID:28039360) RGD PMID:28039360 MGI:5896692 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
JBrowse link
G Lpxn leupaxin involved_in IBA
ISO
PMID:21873635
(MGI:3722965|PMID:17640867)
(PMID:17640867)
RGD PMID:17640867 PMID:21873635 MGI:3722965, RGD:13792537 NCBI chr 1:209,928,297...209,963,085
Ensembl chr 1:209,929,202...209,963,084
JBrowse link
G Plcl2 phospholipase C-like 2 acts_upstream_of_or_within ISO MGI:2679632 (MGI:2677607|PMID:14517301) RGD PMID:14517301 MGI:2677607 NCBI chr 9:3,292,564...3,477,009
Ensembl chr 9:3,292,695...3,477,009
JBrowse link
negative regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07035561.2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr12:17,364,080...17,365,280 JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within ISO (MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:5520006 NCBI chr17:41,620,807...41,632,621
Ensembl chr17:41,620,839...41,632,618
JBrowse link
G Btnl2 butyrophilin-like 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3775536|PMID:16751379)
Ensembl
RGD
PMID:16751379 GO_REF:0000107 MGI:3775536 NCBI chr20:4,490,904...4,502,557
Ensembl chr20:4,489,517...4,503,341
JBrowse link
G Cblb Cbl proto-oncogene B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2180572 (MGI:3041371|PMID:14738763)
Ensembl
RGD
PMID:14738763 GO_REF:0000107 MGI:3041371 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:18193050) RGD PMID:18193050 NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO
ISS
(PMID:18424730)
GO_REF:0000024
RGD
UniProt
PMID:18424730 GO_REF:0000024 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in ISS
ISO
GO_REF:0000024
(MGI:2672999|PMID:12883552)
UniProt
RGD
PMID:12883552 GO_REF:0000024 MGI:2672999 NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:77,904,150...77,946,099
JBrowse link
G Dusp22 dual specificity phosphatase 22 acts_upstream_of_or_within ISO (MGI:5583944|PMID:24714587) RGD PMID:24714587 MGI:5583944 NCBI chr17:33,780,980...33,831,540
Ensembl chr17:33,780,981...33,831,321
JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in IBA
ISO
PMID:21873635
(PMID:12447358)
RGD PMID:12447358 PMID:21873635 RGD:13792537 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962
JBrowse link
G Elf1 E74 like ETS transcription factor 1 acts_upstream_of_or_within ISO MGI:1926074 (MGI:3041371|PMID:14738763) RGD PMID:14738763 MGI:3041371 NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699
JBrowse link
G Ezr ezrin involved_in ISO (PMID:20551903) RGD PMID:20551903 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G Gbp1 guanylate binding protein 1 involved_in ISO (PMID:24337748) RGD PMID:24337748 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,517,398...231,529,600
JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:3803048|PMID:18619870) RGD PMID:18619870 MGI:3803048 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807
JBrowse link
G Lgals3 galectin 3 involved_in ISO (MGI:4355752|PMID:19706535) RGD PMID:19706535 MGI:4355752 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:16493035), (PMID:22387553) RGD PMID:16493035 PMID:22387553 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
G Pawr pro-apoptotic WT1 regulator involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2678021 (MGI:2675524|PMID:12970181)
Ensembl
RGD
PMID:12970181 GO_REF:0000107 MGI:2675524 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Phpt1 phosphohistidine phosphatase 1 involved_in ISO (PMID:18796614) RGD PMID:18796614 NCBI chr 3:8,392,926...8,394,325 JBrowse link
G Prnp prion protein involved_in ISO (MGI:4943618|PMID:20145049) RGD PMID:20145049 MGI:4943618 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5320871|PMID:22080863)
UniProt
RGD
PMID:22080863 GO_REF:0000024 MGI:5320871 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:18056643) RGD PMID:18056643 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856074 (MGI:82729|PMID:9064344)
Ensembl
RGD
PMID:9064344 GO_REF:0000107 MGI:82729 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:11259588), (PMID:12913111), (PMID:9780142)
(MGI:4942249|PMID:12913111)
RGD PMID:9780142 PMID:11259588 PMID:12913111 MGI:4942249 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260
JBrowse link
G Pvrig PVR related immunoglobulin domain containing involved_in ISO (PMID:26755705) RGD PMID:26755705 NCBI chr12:17,363,721...17,365,577 JBrowse link
G Sh2d1a SH2 domain containing 1A involved_in ISO (PMID:9774102) RGD PMID:9774102 NCBI chr  X:121,373,693...121,401,923 JBrowse link
G Sla2 Src-like-adaptor 2 involved_in ISO (PMID:11891219) RGD PMID:11891219 NCBI chr 3:145,367,070...145,383,586
Ensembl chr 3:145,368,598...145,382,480
JBrowse link
G Thy1 Thy-1 cell surface antigen involved_in ISS
ISO
GO_REF:0000024
(MGI:1096761|PMID:9285719)
UniProt
RGD
PMID:9285719 GO_REF:0000024 MGI:1096761 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing, A involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:107180 (MGI:3041371|PMID:14738763)
RGD PMID:14738763 PMID:21873635 MGI:3041371, RGD:13792537 NCBI chr20:9,291,471...9,334,685
Ensembl chr20:9,292,139...9,329,224
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    immune system process 2911
      negative regulation of immune system process 452
        negative regulation of antigen receptor-mediated signaling pathway 34
          negative regulation of B cell receptor signaling pathway 7
          negative regulation of T cell receptor signaling pathway + 27
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological process 12769
        regulation of immune system process 1531
          positive regulation of immune system process 994
            positive regulation of immune response 631
              activation of immune response 402
                immune response-activating signal transduction 321
                  immune response-activating cell surface receptor signaling pathway 320
                    antigen receptor-mediated signaling pathway 280
                      regulation of antigen receptor-mediated signaling pathway 65
                        negative regulation of antigen receptor-mediated signaling pathway 34
                          negative regulation of B cell receptor signaling pathway 7
                          negative regulation of T cell receptor signaling pathway + 27
paths to the root