Phpt1 (phosphohistidine phosphatase 1) - Rat Genome Database

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Gene: Phpt1 (phosphohistidine phosphatase 1) Rattus norvegicus
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Symbol: Phpt1
Name: phosphohistidine phosphatase 1
RGD ID: 1311355
Description: Predicted to enable calcium channel inhibitor activity; protein histidine phosphatase activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of ATP citrate synthase activity; negative regulation of T cell receptor signaling pathway; and peptidyl-histidine dephosphorylation. Predicted to be located in nuclear body and plasma membrane. Predicted to be active in cytosol. Orthologous to human PHPT1 (phosphohistidine phosphatase 1); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 14 kDa phosphohistidine phosphatase; LOC296571
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,392,926 - 8,394,325 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx311,498,106 - 11,499,505 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0320,084,332 - 20,085,731 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,274,175 - 18,275,574 (-)NCBIRnor_WKY
Rnor_6.032,797,037 - 2,798,436 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,796,997 - 2,798,470 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,778,450 - 2,779,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,744,947 - 3,746,346 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,745,120 - 3,746,334 (-)NCBI
Celera33,217,877 - 3,219,276 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells. Kamath V, etal., Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E276-86. doi: 10.1152/ajpendo.00091.2010. Epub 2010 May 25.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12383260   PMID:12477932   PMID:16219293   PMID:18656514   PMID:18796614   PMID:19056867   PMID:19138678   PMID:19344975   PMID:20110805   PMID:23376485  


Genomics

Comparative Map Data
Phpt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,392,926 - 8,394,325 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx311,498,106 - 11,499,505 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0320,084,332 - 20,085,731 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,274,175 - 18,275,574 (-)NCBIRnor_WKY
Rnor_6.032,797,037 - 2,798,436 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,796,997 - 2,798,470 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,778,450 - 2,779,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,744,947 - 3,746,346 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,745,120 - 3,746,334 (-)NCBI
Celera33,217,877 - 3,219,276 (-)NCBICelera
Cytogenetic Map3p13NCBI
PHPT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,849,409 - 136,851,024 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9136,848,724 - 136,851,027 (+)EnsemblGRCh38hg38GRCh38
GRCh379139,743,861 - 139,745,476 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,863,367 - 138,865,311 (+)NCBINCBI36Build 36hg18NCBI36
Build 349137,019,382 - 137,021,327NCBI
Celera9110,257,046 - 110,259,279 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,202,666 - 109,204,708 (+)NCBIHuRef
CHM1_19139,891,999 - 139,894,223 (+)NCBICHM1_1
T2T-CHM13v2.09149,083,591 - 149,085,206 (+)NCBIT2T-CHM13v2.0
Phpt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,463,442 - 25,465,602 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,463,442 - 25,465,236 (-)EnsemblGRCm39 Ensembl
GRCm38225,573,430 - 25,575,514 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,573,430 - 25,575,224 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,428,951 - 25,430,391 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,395,440 - 25,396,880 (-)NCBIMGSCv36mm8
Celera225,301,192 - 25,302,632 (-)NCBICelera
Cytogenetic Map2A3NCBI
Phpt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,930,951 - 4,932,509 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,930,951 - 4,932,509 (+)NCBIChiLan1.0ChiLan1.0
PHPT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19136,877,274 - 136,878,317 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v09107,906,160 - 107,908,130 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PHPT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,736,310 - 48,737,771 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,736,333 - 48,737,725 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,949,921 - 47,951,381 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,614,346 - 49,615,806 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,614,371 - 49,615,763 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,390,569 - 48,392,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,689,275 - 48,690,734 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,736,240 - 48,737,700 (-)NCBIUU_Cfam_GSD_1.0
Phpt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,307,826 - 202,309,158 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,065,900 - 1,067,214 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366691,065,901 - 1,067,214 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHPT1
(Sus scrofa - pig)
No map positions available.
PHPT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,338,205 - 1,340,143 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,338,388 - 1,339,753 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660583,936,606 - 3,938,603 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000022495
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat

Markers in Region
RH137697  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,395,110 - 8,395,272 (+)MAPPERmRatBN7.2
Rnor_6.032,799,222 - 2,799,383NCBIRnor6.0
Rnor_5.032,780,635 - 2,780,796UniSTSRnor5.0
RGSC_v3.433,747,132 - 3,747,293UniSTSRGSC3.4
Celera33,220,062 - 3,220,223UniSTS
Cytogenetic Map3p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022495   ⟹   ENSRNOP00000022495
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl32,796,997 - 2,798,470 (-)Ensembl
RefSeq Acc Id: NM_001106558   ⟹   NP_001100028
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,392,926 - 8,394,325 (-)NCBI
Rnor_6.032,797,037 - 2,798,436 (-)NCBI
Rnor_5.032,778,450 - 2,779,849 (-)NCBI
RGSC_v3.433,744,947 - 3,746,346 (-)RGD
Celera33,217,877 - 3,219,276 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93563 (Get FASTA)   NCBI Sequence Viewer  
  EDL93564 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100028   ⟸   NM_001106558
- UniProtKB: D3ZP47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022495   ⟸   ENSRNOT00000022495

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZP47-F1-model_v2 AlphaFold D3ZP47 1-124 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691884
Promoter ID:EPDNEW_R2408
Type:multiple initiation site
Name:Phpt1_1
Description:phosphohistidine phosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,798,439 - 2,798,499EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311355 AgrOrtholog
BioCyc Gene G2FUF-50439 BioCyc
Ensembl Genes ENSRNOG00000016723 Ensembl
NCBI Gene 296571 ENTREZGENE
PhenoGen Phpt1 PhenoGen
UniProt D3ZP47 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Phpt1  phosphohistidine phosphatase 1   Phpt1_predicted  phosphohistidine phosphatase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Phpt1_predicted  phosphohistidine phosphatase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED