Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Phpt1 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Phpt1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PHPT1 mRNA | CTD | PMID:22206623 | Phpt1 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Phpt1 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of PHPT1 mRNA | CTD | PMID:17555576 | Phpt1 | Rat | 17beta-estradiol 3-benzoate | decreases methylation | EXP | | 6480464 | estradiol 3-benzoate results in decreased methylation of PHPT1 promoter | CTD | PMID:27415467 | Phpt1 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Phpt1 | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of PHPT1 protein | CTD | PMID:31675489 | Phpt1 | Rat | 5-aza-2'-deoxycytidine | affects expression | ISO | PHPT1 (Homo sapiens) | 6480464 | Decitabine affects the expression of PHPT1 mRNA | CTD | PMID:23300844 | Phpt1 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of PHPT1 mRNA | CTD | PMID:30047161 | Phpt1 | Rat | actinomycin D | multiple interactions | ISO | PHPT1 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of PHPT1 protein | CTD | PMID:38460933 | Phpt1 | Rat | aflatoxin B1 | increases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of PHPT1 mRNA | CTD | PMID:27153756 | Phpt1 | Rat | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of PHPT1 mRNA | CTD | PMID:30047161 | Phpt1 | Rat | aristolochic acid A | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PHPT1 mRNA | CTD | PMID:33212167 | Phpt1 | Rat | Aroclor 1254 | increases expression | ISO | Phpt1 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of PHPT1 mRNA | CTD | PMID:23650126 | Phpt1 | Rat | benzo[a]pyrene | affects methylation | ISO | PHPT1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PHPT1 promoter | CTD | PMID:27901495 | Phpt1 | Rat | beta-lapachone | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of PHPT1 mRNA | CTD | PMID:38218311 | Phpt1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PHPT1 mRNA | CTD | PMID:25181051 more ... | Phpt1 | Rat | bisphenol A | increases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PHPT1 protein | CTD | PMID:37567409 | Phpt1 | Rat | bisphenol A | affects expression | ISO | PHPT1 (Homo sapiens) | 6480464 | bisphenol A affects the expression of PHPT1 mRNA | CTD | PMID:30903817 | Phpt1 | Rat | cadmium dichloride | affects methylation | EXP | | 6480464 | Cadmium Chloride affects the methylation of PHPT1 promoter | CTD | PMID:22457795 | Phpt1 | Rat | cadmium dichloride | increases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of PHPT1 mRNA | CTD | PMID:26472689 | Phpt1 | Rat | chlordecone | decreases expression | ISO | Phpt1 (Mus musculus) | 6480464 | Chlordecone results in decreased expression of PHPT1 mRNA | CTD | PMID:33711761 | Phpt1 | Rat | chloropicrin | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | chloropicrin results in decreased expression of PHPT1 mRNA | CTD | PMID:26352163 | Phpt1 | Rat | choline | multiple interactions | EXP | | 6480464 | [Folic Acid deficiency co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of PHPT1 protein | CTD | PMID:19566968 | Phpt1 | Rat | chromium(6+) | affects expression | ISO | Phpt1 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of PHPT1 mRNA | CTD | PMID:28472532 | Phpt1 | Rat | cisplatin | affects expression | ISO | PHPT1 (Homo sapiens) | 6480464 | Cisplatin affects the expression of PHPT1 mRNA | CTD | PMID:23300844 | Phpt1 | Rat | copper(II) sulfate | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of PHPT1 mRNA | CTD | PMID:19549813 | Phpt1 | Rat | decabromodiphenyl ether | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of PHPT1 protein | CTD | PMID:31675489 | Phpt1 | Rat | diazinon | increases methylation | ISO | PHPT1 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of PHPT1 gene | CTD | PMID:22964155 | Phpt1 | Rat | Dibutyl phosphate | affects expression | ISO | PHPT1 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PHPT1 mRNA | CTD | PMID:37042841 | Phpt1 | Rat | dibutyl phthalate | decreases expression | ISO | Phpt1 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of PHPT1 mRNA | CTD | PMID:21266533 | Phpt1 | Rat | doxorubicin | increases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of PHPT1 mRNA | CTD | PMID:29803840 | Phpt1 | Rat | epoxiconazole | increases expression | ISO | Phpt1 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of PHPT1 mRNA | CTD | PMID:35436446 | Phpt1 | Rat | ethyl methanesulfonate | increases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of PHPT1 mRNA | CTD | PMID:23649840 | Phpt1 | Rat | fenthion | increases expression | ISO | Phpt1 (Mus musculus) | 6480464 | Fenthion results in increased expression of PHPT1 mRNA | CTD | PMID:34813904 | Phpt1 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of PHPT1 mRNA | CTD | PMID:24136188 | Phpt1 | Rat | folic acid | multiple interactions | EXP | | 6480464 | [Folic Acid deficiency co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of PHPT1 protein | CTD | PMID:19566968 | Phpt1 | Rat | folic acid | multiple interactions | ISO | Phpt1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PHPT1 mRNA | CTD | PMID:22206623 | Phpt1 | Rat | folpet | increases expression | ISO | Phpt1 (Mus musculus) | 6480464 | folpet results in increased expression of PHPT1 mRNA | CTD | PMID:31558096 | Phpt1 | Rat | formaldehyde | increases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of PHPT1 mRNA | CTD | PMID:23649840 | Phpt1 | Rat | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of PHPT1 mRNA | CTD | PMID:24136188 | Phpt1 | Rat | hypochlorous acid | decreases expression | ISO | Phpt1 (Mus musculus) | 6480464 | Hypochlorous Acid results in decreased expression of PHPT1 mRNA | CTD | PMID:19376150 | Phpt1 | Rat | ivermectin | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PHPT1 protein | CTD | PMID:32959892 | Phpt1 | Rat | L-methionine | multiple interactions | EXP | | 6480464 | [Folic Acid deficiency co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of PHPT1 protein | CTD | PMID:19566968 | Phpt1 | Rat | methidathion | increases expression | ISO | Phpt1 (Mus musculus) | 6480464 | methidathion results in increased expression of PHPT1 mRNA | CTD | PMID:34813904 | Phpt1 | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of PHPT1 mRNA | CTD | PMID:30047161 | Phpt1 | Rat | methyl methanesulfonate | increases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of PHPT1 mRNA | CTD | PMID:23649840 | Phpt1 | Rat | methylparaben | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | methylparaben results in decreased expression of PHPT1 mRNA | CTD | PMID:38568856 | Phpt1 | Rat | microcystin RR | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | microcystin RR results in decreased expression of PHPT1 protein | CTD | PMID:19111056 | Phpt1 | Rat | Nutlin-3 | multiple interactions | ISO | PHPT1 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of PHPT1 protein | CTD | PMID:38460933 | Phpt1 | Rat | perfluorooctane-1-sulfonic acid | decreases expression | ISO | Phpt1 (Mus musculus) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of PHPT1 protein | CTD | PMID:26178269 | Phpt1 | Rat | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of PHPT1 mRNA | CTD | PMID:30047161 | Phpt1 | Rat | SB 431542 | multiple interactions | ISO | PHPT1 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of PHPT1 protein | CTD | PMID:37664457 | Phpt1 | Rat | sodium arsenite | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PHPT1 mRNA and sodium arsenite results in decreased expression of PHPT1 protein | CTD | PMID:25879800 more ... | Phpt1 | Rat | sodium fluoride | decreases expression | ISO | Phpt1 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of PHPT1 protein | CTD | PMID:28918527 | Phpt1 | Rat | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of PHPT1 mRNA | CTD | PMID:30047161 | Phpt1 | Rat | sulforaphane | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of PHPT1 mRNA | CTD | PMID:31838189 | Phpt1 | Rat | tamoxifen | affects expression | ISO | Phpt1 (Mus musculus) | 6480464 | Tamoxifen affects the expression of PHPT1 mRNA | CTD | PMID:17555576 | Phpt1 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | [Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of PHPT1 protein | CTD | PMID:25303780 | Phpt1 | Rat | titanium dioxide | increases methylation | ISO | Phpt1 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of PHPT1 gene | CTD | PMID:35295148 | Phpt1 | Rat | titanium dioxide | decreases methylation | ISO | Phpt1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of PHPT1 gene | CTD | PMID:35295148 | Phpt1 | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of PHPT1 mRNA | CTD | PMID:33387578 | Phpt1 | Rat | tungsten | increases expression | ISO | Phpt1 (Mus musculus) | 6480464 | Tungsten results in increased expression of PHPT1 mRNA | CTD | PMID:30912803 | Phpt1 | Rat | valproic acid | increases methylation | ISO | PHPT1 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of PHPT1 gene | CTD | PMID:29154799 | Phpt1 | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of PHPT1 mRNA | CTD | PMID:29427782 | Phpt1 | Rat | valproic acid | decreases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PHPT1 mRNA | CTD | PMID:23179753 and PMID:29154799 | Phpt1 | Rat | valproic acid | affects expression | ISO | PHPT1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PHPT1 mRNA | CTD | PMID:25979313 | Phpt1 | Rat | zoledronic acid | increases expression | ISO | PHPT1 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of PHPT1 mRNA | CTD | PMID:20977926 | |