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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of antigen receptor-mediated signaling pathway
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Accession:GO:0050854 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
Synonyms:exact_synonym: regulation of antigen receptor mediated signalling pathway



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negative regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd22 CD22 molecule involved_in IBA
ISO
PMID:21873635
(PMID:24169826), (PMID:26017478)
RGD PMID:24169826 PMID:26017478 PMID:21873635 RGD:13792537 NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322
JBrowse link
G Cd300a Cd300a molecule involved_in ISO (PMID:21482706) RGD PMID:21482706 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
JBrowse link
G Fcgr2b Fc gamma receptor 2B involved_in ISO (PMID:24169826) RGD PMID:24169826 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Fcrl5 Fc receptor-like 5 acts_upstream_of_or_within ISO MGI:96055|MGI:96892 (MGI:5471851|PMID:23509253) RGD PMID:23509253 MGI:5471851 NCBI chr 2:172,881,763...172,912,912
Ensembl chr 2:172,881,448...172,913,148
JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:5896692|PMID:28039360) RGD PMID:28039360 MGI:5896692 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
JBrowse link
G Lpxn leupaxin involved_in IBA
ISO
PMID:21873635
(MGI:3722965|PMID:17640867)
(PMID:17640867)
RGD PMID:17640867 PMID:21873635 MGI:3722965, RGD:13792537 NCBI chr 1:209,928,297...209,963,085
Ensembl chr 1:209,929,202...209,963,084
JBrowse link
G Mir34a microRNA 34a involved_in ISO (PMID:30111844) RGD PMID:30111844 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
JBrowse link
G Plcl2 phospholipase C-like 2 acts_upstream_of_or_within ISO MGI:2679632 (MGI:2677607|PMID:14517301) RGD PMID:14517301 MGI:2677607 NCBI chr 9:3,292,564...3,477,009
Ensembl chr 9:3,292,695...3,477,009
JBrowse link
negative regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07035561.2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr12:17,364,080...17,365,280 JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within ISO (MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:5520006 NCBI chr17:41,620,807...41,632,621
Ensembl chr17:41,620,839...41,632,618
JBrowse link
G Btnl2 butyrophilin-like 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3775536|PMID:16751379)
Ensembl
RGD
PMID:16751379 GO_REF:0000107 MGI:3775536 NCBI chr20:4,490,904...4,502,557
Ensembl chr20:4,489,517...4,503,341
JBrowse link
G Cblb Cbl proto-oncogene B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2180572 (MGI:3041371|PMID:14738763)
Ensembl
RGD
PMID:14738763 GO_REF:0000107 MGI:3041371 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:18193050) RGD PMID:18193050 NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO
ISS
(PMID:18424730)
GO_REF:0000024
RGD
UniProt
PMID:18424730 GO_REF:0000024 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in ISS
ISO
GO_REF:0000024
(MGI:2672999|PMID:12883552)
UniProt
RGD
PMID:12883552 GO_REF:0000024 MGI:2672999 NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:77,904,150...77,946,099
JBrowse link
G Dusp22 dual specificity phosphatase 22 acts_upstream_of_or_within ISO (MGI:5583944|PMID:24714587) RGD PMID:24714587 MGI:5583944 NCBI chr17:33,780,980...33,831,540
Ensembl chr17:33,780,981...33,831,321
JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in IBA
ISO
PMID:21873635
(PMID:12447358)
RGD PMID:12447358 PMID:21873635 RGD:13792537 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962
JBrowse link
G Elf1 E74 like ETS transcription factor 1 acts_upstream_of_or_within ISO MGI:1926074 (MGI:3041371|PMID:14738763) RGD PMID:14738763 MGI:3041371 NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699
JBrowse link
G Ezr ezrin involved_in ISO (PMID:20551903) RGD PMID:20551903 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G Gbp1 guanylate binding protein 1 involved_in ISO (PMID:24337748) RGD PMID:24337748 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:3803048|PMID:18619870) RGD PMID:18619870 MGI:3803048 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807
JBrowse link
G Lgals3 galectin 3 involved_in ISO (MGI:4355752|PMID:19706535) RGD PMID:19706535 MGI:4355752 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:16493035), (PMID:22387553) RGD PMID:16493035 PMID:22387553 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
G Pawr pro-apoptotic WT1 regulator acts_upstream_of_or_within ISO MGI:2678021 (MGI:2675524|PMID:12970181) RGD PMID:12970181 MGI:2675524 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Phpt1 phosphohistidine phosphatase 1 involved_in ISO (PMID:18796614) RGD PMID:18796614 NCBI chr 3:8,392,926...8,394,325 JBrowse link
G Prnp prion protein involved_in ISO (MGI:4943618|PMID:20145049) RGD PMID:20145049 MGI:4943618 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5320871|PMID:22080863)
UniProt
RGD
PMID:22080863 GO_REF:0000024 MGI:5320871 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:18056643) RGD PMID:18056643 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856074 (MGI:82729|PMID:9064344)
Ensembl
RGD
PMID:9064344 GO_REF:0000107 MGI:82729 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:11259588), (PMID:12913111), (PMID:9780142)
(MGI:4942249|PMID:12913111)
RGD PMID:9780142 PMID:11259588 PMID:12913111 MGI:4942249 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260
JBrowse link
G Pvrig PVR related immunoglobulin domain containing involved_in ISO
IBA
(PMID:26755705)
PMID:21873635
RGD PMID:26755705 PMID:21873635 RGD:13792537 NCBI chr12:17,363,721...17,365,577
Ensembl chr12:17,364,080...17,365,280
JBrowse link
G Sh2d1a SH2 domain containing 1A involved_in ISO (PMID:9774102) RGD PMID:9774102 NCBI chr  X:121,373,693...121,401,923 JBrowse link
G Sla2 Src-like-adaptor 2 involved_in ISO (PMID:11891219) RGD PMID:11891219 NCBI chr 3:145,367,070...145,383,586
Ensembl chr 3:145,368,598...145,382,480
JBrowse link
G Thy1 Thy-1 cell surface antigen involved_in ISS
ISO
GO_REF:0000024
(MGI:1096761|PMID:9285719)
UniProt
RGD
PMID:9285719 GO_REF:0000024 MGI:1096761 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing, A involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:107180 (MGI:3041371|PMID:14738763)
RGD PMID:14738763 PMID:21873635 MGI:3041371, RGD:13792537 NCBI chr20:9,291,471...9,334,685
Ensembl chr20:9,292,139...9,329,224
JBrowse link
positive regulation of antigen receptor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISS
ISO
GO_REF:0000024
(MGI:3687418|PMID:8692271)
UniProt
RGD
PMID:8692271 GO_REF:0000024 MGI:3687418 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
positive regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISS
ISO
GO_REF:0000024
(MGI:5476553|PMID:23499492)
(PMID:20237408)
UniProt
RGD
PMID:20237408 PMID:23499492 GO_REF:0000024 MGI:5476553 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660
JBrowse link
G Cmtm3 CKLF-like MARVEL transmembrane domain containing 3 acts_upstream_of_or_within ISO (MGI:3047050|PMID:15196959) RGD PMID:15196959 MGI:3047050 NCBI chr19:622,563...630,721
Ensembl chr19:604,458...629,790
JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:30111844) RGD PMID:30111844 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
JBrowse link
G Mir18a microRNA 18a involved_in ISO (PMID:24169826) RGD PMID:24169826 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
JBrowse link
G Mir19a microRNA 19a involved_in ISO (PMID:24169826), (PMID:26017478) RGD PMID:24169826 PMID:26017478 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
JBrowse link
G Nfam1 NFAT activating protein with ITAM motif 1 involved_in ISO (MGI:3044463|PMID:15143214) RGD PMID:15143214 MGI:3044463 NCBI chr 7:114,139,318...114,175,395
Ensembl chr 7:114,139,345...114,175,442
JBrowse link
G Prkcb protein kinase C, beta involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:3700457|PMID:16301747)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:16301747 GO_REF:0000024 GO_REF:0000107 MGI:3700457 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkch protein kinase C, eta involved_in ISO
ISS
(PMID:18780722)
GO_REF:0000024
RGD
UniProt
PMID:18780722 GO_REF:0000024 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
JBrowse link
G Slc39a10 solute carrier family 39 member 10 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:5642299 (MGI:5586914|PMID:25074919)
RGD PMID:25074919 PMID:21873635 MGI:5586914, RGD:13792537 NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325
JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in ISO
IBA
(PMID:10518561)
PMID:21873635
RGD PMID:10518561 PMID:21873635 RGD:13792537 NCBI chr14:21,950,466...21,981,395
Ensembl chr14:21,952,496...21,981,245
JBrowse link
positive regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO MGI:1857117|MGI:2683027 (MGI:3640996|PMID:11435465) RGD PMID:11435465 MGI:3640996 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Bcl10 BCL10, immune signaling adaptor involved_in ISS
ISO
GO_REF:0000024
(PMID:18287044), (PMID:27777308)
UniProt
RGD
PMID:18287044 PMID:27777308 GO_REF:0000024 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
JBrowse link
G Card11 caspase recruitment domain family, member 11 involved_in ISO (PMID:12154360)
(MGI:6695669|PMID:12154356)
RGD PMID:12154356 PMID:12154360 MGI:6695669 NCBI chr12:13,620,979...13,758,115
Ensembl chr12:13,621,087...13,758,112
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (MGI:3847607|PMID:17785582) RGD PMID:17785582 MGI:3847607 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cd226 CD226 molecule involved_in ISO
IBA
(PMID:26755705)
PMID:21873635
RGD PMID:26755705 PMID:21873635 RGD:13792537 NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051
JBrowse link
G Cd81 Cd81 molecule involved_in ISO
ISS
(PMID:23858057)
GO_REF:0000024
RGD
UniProt
PMID:23858057 GO_REF:0000024 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO MGI:3664438 (MGI:3656194|PMID:16501569) RGD PMID:16501569 MGI:3656194 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma involved_in ISS
ISO
GO_REF:0000024
(PMID:18287044), (PMID:27777308)
UniProt
RGD
PMID:18287044 PMID:27777308 GO_REF:0000024 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 involved_in ISO
IEA
(PMID:18796614)
GO_REF:0000107
RGD
Ensembl
PMID:18796614 GO_REF:0000107 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO
IBA
(PMID:26755705)
PMID:21873635
RGD PMID:26755705 PMID:21873635 RGD:13792537 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
JBrowse link
G Prkd2 protein kinase D2 involved_in ISS
ISO
GO_REF:0000024
(MGI:4849903|PMID:20819079)
UniProt
RGD
PMID:20819079 GO_REF:0000024 MGI:4849903 NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376
JBrowse link
G Rab29 RAB29, member RAS oncogene family involved_in ISO (PMID:26021297) RGD PMID:26021297 NCBI chr13:43,307,757...43,313,420
Ensembl chr13:43,307,775...43,313,417
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in ISO (PMID:18045535) RGD PMID:18045535 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:18045535) RGD PMID:18045535 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680
JBrowse link
G Trat1 T cell receptor associated transmembrane adaptor 1 acts_upstream_of_or_within
involved_in
ISO
IBA
(PMID:11390434)
PMID:21873635
RGD PMID:11390434 PMID:21873635 RGD:13792537 NCBI chr11:52,035,750...52,077,805
Ensembl chr11:52,035,750...52,077,805
JBrowse link
regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blk BLK proto-oncogene, Src family tyrosine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031
JBrowse link
G Cd19 CD19 molecule involved_in ISO (PMID:9382888)
(MGI:1100180|PMID:9382888)
RGD PMID:9382888 MGI:1100180 NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975
JBrowse link
G Gcsam germinal center-associated, signaling and motility involved_in IBA
ISO
PMID:21873635
(PMID:23299888)
RGD PMID:23299888 PMID:21873635 RGD:13792537 NCBI chr11:55,195,757...55,207,011
Ensembl chr11:55,196,712...55,206,992
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IBA
ISO
ISS
PMID:21873635
(MGI:2152233|PMID:11672542)
GO_REF:0000024
RGD
UniProt
PMID:11672542 PMID:21873635 GO_REF:0000024 MGI:2152233, RGD:13792537 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl10 BCL10, immune signaling adaptor acts_upstream_of_or_within ISO MGI:2158304 (MGI:3629264|PMID:14614861) RGD PMID:14614861 MGI:3629264 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
JBrowse link
G Cd300a Cd300a molecule involved_in ISO (PMID:22046970) RGD PMID:22046970 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO (MGI:3042327|PMID:14752163) RGD PMID:14752163 MGI:3042327 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Malt1 MALT1 paracaspase acts_upstream_of_or_within ISO MGI:3639305 (MGI:3629264|PMID:14614861) RGD PMID:14614861 MGI:3629264 NCBI chr18:58,942,282...58,996,318
Ensembl chr18:58,942,299...58,994,260
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:3580753|PMID:15917799) RGD PMID:15917799 MGI:3580753 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    immune system process 2730
      immune response 1667
        regulation of immune response 883
          regulation of antigen receptor-mediated signaling pathway 67
            negative regulation of antigen receptor-mediated signaling pathway + 35
            positive regulation of antigen receptor-mediated signaling pathway + 25
            regulation of B cell receptor signaling pathway + 22
            regulation of T cell receptor signaling pathway + 46
Path 2
Term Annotations click to browse term
  biological_process 18737
    biological regulation 13318
      regulation of biological process 12598
        positive regulation of biological process 6664
          positive regulation of immune system process 963
            positive regulation of immune response 568
              activation of immune response 340
                immune response-activating signal transduction 261
                  immune response-activating cell surface receptor signaling pathway 260
                    antigen receptor-mediated signaling pathway 213
                      regulation of antigen receptor-mediated signaling pathway 67
                        negative regulation of antigen receptor-mediated signaling pathway + 35
                        positive regulation of antigen receptor-mediated signaling pathway + 25
                        regulation of B cell receptor signaling pathway + 22
                        regulation of T cell receptor signaling pathway + 46
paths to the root