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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of antigen receptor-mediated signaling pathway
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Accession:GO:0050854 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
Synonyms:exact_synonym: regulation of antigen receptor mediated signalling pathway


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negative regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd22 CD22 molecule involved_in IBA
ISO
PMID:21873635
(PMID:24169826), (PMID:26017478)
RGD PMID:24169826 PMID:26017478, PMID:21873635 RGD:13792537 NCBI chr 1:89,313,475...89,329,902
Ensembl chr 1:89,314,558...89,329,418
JBrowse link
G Cd300a Cd300a molecule involved_in ISO (PMID:21482706) RGD PMID:21482706 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb involved_in ISO (PMID:24169826) RGD PMID:24169826 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Fcrl5 Fc receptor-like 5 acts_upstream_of_or_within ISO MGI:96055|MGI:96892 (MGI:5471851|PMID:23509253) RGD PMID:23509253 MGI:5471851 NCBI chr 2:186,776,466...186,797,900
Ensembl chr 2:186,776,605...186,808,078
JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:5896692|PMID:28039360) RGD PMID:28039360 MGI:5896692 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Lpxn leupaxin involved_in IBA
ISO
PMID:21873635
(MGI:3722965|PMID:17640867)
(PMID:17640867)
RGD PMID:17640867, PMID:21873635 MGI:3722965, RGD:13792537 NCBI chr 1:229,642,437...229,674,129
Ensembl chr 1:229,642,412...229,674,134
JBrowse link
G Plcl2 phospholipase C-like 2 acts_upstream_of_or_within ISO MGI:2679632 (MGI:2677607|PMID:14517301) RGD PMID:14517301 MGI:2677607 NCBI chr 9:1,782,536...1,984,654
Ensembl chr 9:1,782,536...1,984,654
JBrowse link
negative regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07035561.2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr12:19,680,712...19,681,832 JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within ISO (MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:5520006 NCBI chr17:43,867,243...43,878,734
Ensembl chr17:43,868,191...43,879,839
JBrowse link
G Btnl2 butyrophilin-like 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3775536|PMID:16751379)
Ensembl
RGD
PMID:16751379 GO_REF:0000107 MGI:3775536 NCBI chr20:4,140,184...4,156,365
Ensembl chr20:4,141,878...4,154,978
JBrowse link
G Cblb Cbl proto-oncogene B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2180572 (MGI:3041371|PMID:14738763)
Ensembl
RGD
PMID:14738763 GO_REF:0000107 MGI:3041371 NCBI chr11:51,037,383...51,202,761
Ensembl chr11:51,037,393...51,202,820
JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:18193050) RGD PMID:18193050 NCBI chr 2:198,933,681...198,965,380
Ensembl chr 2:198,935,133...198,942,732
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO
ISS
(PMID:18424730)
GO_REF:0000024
RGD
UniProt
PMID:18424730 GO_REF:0000024 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in ISS
ISO
GO_REF:0000024
(MGI:2672999|PMID:12883552)
UniProt
RGD
PMID:12883552 GO_REF:0000024 MGI:2672999 NCBI chr 3:80,844,002...80,886,487
Ensembl chr 3:80,844,005...80,875,817
JBrowse link
G Dusp22 dual specificity phosphatase 22 acts_upstream_of_or_within ISO (MGI:5583944|PMID:24714587) RGD PMID:24714587 MGI:5583944 NCBI chr17:34,986,589...35,037,297
Ensembl chr17:34,986,591...35,037,076
JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in IBA
ISO
PMID:21873635
(PMID:12447358)
RGD PMID:12447358, PMID:21873635 RGD:13792537 NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
JBrowse link
G Elf1 E74 like ETS transcription factor 1 acts_upstream_of_or_within ISO MGI:1926074 (MGI:3041371|PMID:14738763) RGD PMID:14738763 MGI:3041371 NCBI chr15:61,772,544...61,868,442
Ensembl chr15:61,826,711...61,868,343
JBrowse link
G Ezr ezrin involved_in ISO (PMID:20551903) RGD PMID:20551903 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Gbp1 guanylate binding protein 1 involved_in ISO (PMID:24337748) RGD PMID:24337748 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:3803048|PMID:18619870) RGD PMID:18619870 MGI:3803048 NCBI chr 5:149,015,793...149,069,719
Ensembl chr 5:149,047,681...149,069,719
JBrowse link
G Lgals3 galectin 3 involved_in ISO (MGI:4355752|PMID:19706535) RGD PMID:19706535 MGI:4355752 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:16493035), (PMID:22387553) RGD PMID:16493035 PMID:22387553 NCBI chr 1:73,393,854...73,399,448
Ensembl chr 1:73,393,850...73,399,579
JBrowse link
G Pawr pro-apoptotic WT1 regulator involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2678021 (MGI:2675524|PMID:12970181)
Ensembl
RGD
PMID:12970181 GO_REF:0000107 MGI:2675524 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Phpt1 phosphohistidine phosphatase 1 involved_in ISO (PMID:18796614) RGD PMID:18796614 NCBI chr 3:2,797,037...2,798,436
Ensembl chr 3:2,796,997...2,798,470
JBrowse link
G Prnp prion protein involved_in ISO (MGI:4943618|PMID:20145049) RGD PMID:20145049 MGI:4943618 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5320871|PMID:22080863)
UniProt
RGD
PMID:22080863 GO_REF:0000024 MGI:5320871 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:18056643) RGD PMID:18056643 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856074 (MGI:82729|PMID:9064344)
Ensembl
RGD
PMID:9064344 GO_REF:0000107 MGI:82729 NCBI chr 4:157,239,141...157,263,890
Ensembl chr 4:157,239,142...157,263,890
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:11259588), (PMID:12913111), (PMID:9780142)
(MGI:4942249|PMID:12913111)
RGD PMID:9780142 PMID:11259588 PMID:12913111 MGI:4942249 NCBI chr 3:79,233,519...79,390,956
Ensembl chr 3:79,233,525...79,390,956
JBrowse link
G Pvrig PVR related immunoglobulin domain containing involved_in ISO (PMID:26755705) RGD PMID:26755705 NCBI chr12:19,679,671...19,681,861 JBrowse link
G Sh2d1a SH2 domain containing 1A involved_in ISO (PMID:9774102) RGD PMID:9774102 NCBI chr  X:128,897,053...128,925,408
Ensembl chr  X:128,897,181...128,925,407
JBrowse link
G Sla2 Src-like-adaptor 2 involved_in ISO (PMID:11891219) RGD PMID:11891219 NCBI chr 3:152,942,838...153,004,047
Ensembl chr 3:152,944,452...153,001,309
JBrowse link
G Thy1 Thy-1 cell surface antigen involved_in ISS
ISO
GO_REF:0000024
(MGI:1096761|PMID:9285719)
UniProt
RGD
PMID:9285719 GO_REF:0000024 MGI:1096761 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing, A involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:107180 (MGI:3041371|PMID:14738763)
RGD PMID:14738763, PMID:21873635 MGI:3041371, RGD:13792537 NCBI chr20:9,941,102...9,986,012
Ensembl chr20:9,948,908...9,985,133
JBrowse link
positive regulation of antigen receptor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISS
ISO
GO_REF:0000024
(MGI:3687418|PMID:8692271)
UniProt
RGD
PMID:8692271 GO_REF:0000024 MGI:3687418 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692
JBrowse link
positive regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:5476553|PMID:23499492)
(PMID:20237408)
UniProt
Ensembl
RGD
PMID:20237408 PMID:23499492 GO_REF:0000024 GO_REF:0000107 MGI:5476553 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Cmtm3 CKLF-like MARVEL transmembrane domain containing 3 acts_upstream_of_or_within ISO (MGI:3047050|PMID:15196959) RGD PMID:15196959 MGI:3047050 NCBI chr19:830,874...838,528
Ensembl chr19:830,877...838,099
JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:30111844) RGD PMID:30111844 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
JBrowse link
G Nfam1 NFAT activating protein with ITAM motif 1 involved_in ISO (MGI:3044463|PMID:15143214) RGD PMID:15143214 MGI:3044463 NCBI chr 7:123,856,718...123,893,790
Ensembl chr 7:123,856,567...123,892,429
JBrowse link
G Prkcb protein kinase C, beta involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:3700457|PMID:16301747)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:16301747 GO_REF:0000024 GO_REF:0000107 MGI:3700457 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkch protein kinase C, eta involved_in ISS
ISO
GO_REF:0000024
(PMID:18780722)
UniProt
RGD
PMID:18780722 GO_REF:0000024 NCBI chr 6:96,479,243...96,677,368
Ensembl chr 6:96,479,430...96,676,225
JBrowse link
G Slc39a10 solute carrier family 39 member 10 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:5642299 (MGI:5586914|PMID:25074919)
RGD PMID:25074919, PMID:21873635 MGI:5586914, RGD:13792537 NCBI chr 9:59,947,562...60,070,549
Ensembl chr 9:60,021,534...60,070,552
JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in ISO
IBA
(PMID:10518561)
PMID:21873635
RGD PMID:10518561, PMID:21873635 RGD:13792537 NCBI chr14:23,575,400...23,604,984
Ensembl chr14:23,576,085...23,604,834
JBrowse link
positive regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07032888.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr18:87,415,531...87,415,884 JBrowse link
G Ada adenosine deaminase acts_upstream_of_or_within ISO MGI:1857117|MGI:2683027 (MGI:3640996|PMID:11435465) RGD PMID:11435465 MGI:3640996 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Bcl10 BCL10, immune signaling adaptor involved_in ISS
ISO
GO_REF:0000024
(PMID:18287044), (PMID:27777308)
UniProt
RGD
PMID:18287044 PMID:27777308 GO_REF:0000024 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Card11 caspase recruitment domain family, member 11 involved_in ISO (PMID:12154360)
(MGI:6695669|PMID:12154356)
RGD PMID:12154356 PMID:12154360 MGI:6695669 NCBI chr12:15,700,600...15,844,512
Ensembl chr12:15,700,825...15,844,512
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (MGI:3847607|PMID:17785582) RGD PMID:17785582 MGI:3847607 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Cd226 CD226 molecule involved_in ISO
IBA
(PMID:26755705)
PMID:21873635
RGD PMID:26755705, PMID:21873635 RGD:13792537 NCBI chr18:86,299,392...86,394,772
Ensembl chr18:86,299,463...86,394,765
JBrowse link
G Cd81 Cd81 molecule involved_in ISO
IEA
ISS
(PMID:23858057)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:23858057 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO MGI:3664438 (MGI:3656194|PMID:16501569) RGD PMID:16501569 MGI:3656194 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma involved_in ISS
ISO
GO_REF:0000024
(PMID:18287044), (PMID:27777308)
UniProt
RGD
PMID:18287044 PMID:27777308 GO_REF:0000024 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:18796614)
Ensembl
RGD
PMID:18796614 GO_REF:0000107 NCBI chr 1:81,227,855...81,245,986
Ensembl chr 1:81,230,612...81,245,996
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO
IBA
(PMID:26755705)
PMID:21873635
RGD PMID:26755705, PMID:21873635 RGD:13792537 NCBI chr 1:80,631,449...80,666,617
Ensembl chr 1:80,631,450...80,666,585
JBrowse link
G Prkd2 protein kinase D2 involved_in ISS
ISO
GO_REF:0000024
(MGI:4849903|PMID:20819079)
UniProt
RGD
PMID:20819079 GO_REF:0000024 MGI:4849903 NCBI chr 1:78,767,911...78,796,223
Ensembl chr 1:78,767,911...78,796,231
JBrowse link
G Rab29 RAB29, member RAS oncogene family involved_in ISO (PMID:26021297) RGD PMID:26021297 NCBI chr13:48,644,575...48,650,229
Ensembl chr13:48,644,604...48,650,220
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in ISO (PMID:18045535) RGD PMID:18045535 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:18045535) RGD PMID:18045535 NCBI chr 1:164,435,868...164,441,167
Ensembl chr 1:164,435,878...164,441,167
JBrowse link
G Trat1 T cell receptor associated transmembrane adaptor 1 acts_upstream_of_or_within ISO (PMID:11390434) RGD PMID:11390434 NCBI chr11:54,619,169...54,661,284
Ensembl chr11:54,619,129...54,662,353
JBrowse link
regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blk BLK proto-oncogene, Src family tyrosine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:46,555,552...46,593,778
Ensembl chr15:46,555,188...46,593,653
JBrowse link
G Cd19 CD19 molecule involved_in ISO (PMID:9382888)
(MGI:1100180|PMID:9382888)
RGD PMID:9382888 MGI:1100180 NCBI chr 1:197,815,422...197,822,123
Ensembl chr 1:197,815,413...197,821,936
JBrowse link
G Gcsam germinal center-associated, signaling and motility involved_in IBA
ISO
PMID:21873635
(PMID:23299888)
RGD PMID:23299888, PMID:21873635 RGD:13792537 NCBI chr11:60,168,938...60,180,191
Ensembl chr11:60,170,985...60,180,118
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IBA
ISO
ISS
PMID:21873635
(MGI:2152233|PMID:11672542)
GO_REF:0000024
RGD
UniProt
PMID:11672542, PMID:21873635 GO_REF:0000024 MGI:2152233, RGD:13792537 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl10 BCL10, immune signaling adaptor acts_upstream_of_or_within ISO MGI:2158304 (MGI:3629264|PMID:14614861) RGD PMID:14614861 MGI:3629264 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Cd300a Cd300a molecule involved_in ISO (PMID:22046970) RGD PMID:22046970 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO (MGI:3042327|PMID:14752163) RGD PMID:14752163 MGI:3042327 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Malt1 MALT1 paracaspase acts_upstream_of_or_within ISO MGI:3639305 (MGI:3629264|PMID:14614861) RGD PMID:14614861 MGI:3629264 NCBI chr18:61,108,712...61,162,446
Ensembl chr18:61,109,069...61,162,445
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:3580753|PMID:15917799) RGD PMID:15917799 MGI:3580753 NCBI chr13:78,723,028...78,794,663
Ensembl chr13:78,722,763...78,789,266
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    immune system process 2886
      immune response 1891
        regulation of immune response 864
          regulation of antigen receptor-mediated signaling pathway 65
            negative regulation of antigen receptor-mediated signaling pathway + 34
            positive regulation of antigen receptor-mediated signaling pathway + 24
            regulation of B cell receptor signaling pathway + 19
            regulation of T cell receptor signaling pathway + 47
Path 2
Term Annotations click to browse term
  biological_process 19612
    biological regulation 13584
      regulation of biological process 12857
        positive regulation of biological process 6587
          positive regulation of immune system process 996
            positive regulation of immune response 638
              activation of immune response 406
                immune response-activating signal transduction 324
                  immune response-activating cell surface receptor signaling pathway 323
                    antigen receptor-mediated signaling pathway 286
                      regulation of antigen receptor-mediated signaling pathway 65
                        negative regulation of antigen receptor-mediated signaling pathway + 34
                        positive regulation of antigen receptor-mediated signaling pathway + 24
                        regulation of B cell receptor signaling pathway + 19
                        regulation of T cell receptor signaling pathway + 47
paths to the root