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leukocyte tethering or rolling - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:leukocyte tethering or rolling
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Accession:GO:0050901 term browser browse the term
Definition:Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).

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show annotations for term's descendants           Sort by:
leukocyte tethering or rolling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Add2 adducin 2 involved_in ISO
IEA 		(PMID:25425738)
GO_REF:0000107 		RGD
Ensembl		 PMID:25425738 GO_REF:0000107 NCBI chr 4:118,444,594...118,538,505
Ensembl chr 4:118,497,416...118,538,505 		JBrowse link
G Chst4 carbohydrate sulfotransferase 4 acts_upstream_of_or_within ISO MGI:2682796 (PMID:14597732) RGD PMID:14597732 NCBI chr19:37,993,471...38,002,123
Ensembl chr19:37,991,417...38,003,608 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 involved_in ISO UniProtKB:O00585|UniProtKB:P19320 (PMID:10187784) RGD PMID:10187784 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO
IEA 		(PMID:21093315)
GO_REF:0000107 		RGD
Ensembl		 PMID:21093315 GO_REF:0000107 NCBI chr 7:86,265,651...86,544,488
Ensembl chr 7:84,375,784...84,655,357 		JBrowse link
G Gcnt1 glucosaminyl (N-acetyl) transferase 1 involved_in ISO (PMID:23027862) RGD PMID:23027862 NCBI chr 1:214,718,344...214,755,735
Ensembl chr 1:214,718,293...214,758,776 		JBrowse link
G Golph3 golgi phosphoprotein 3 involved_in ISO
ISS 		(PMID:23027862)
GO_REF:0000024 		RGD
UniProt		 PMID:23027862 GO_REF:0000024 NCBI chr 2:61,348,030...61,376,051
Ensembl chr 2:61,348,030...61,376,049 		JBrowse link
G Itga4 integrin subunit alpha 4 involved_in ISO
IEA 		(PMID:18308860)
GO_REF:0000107 		RGD
Ensembl		 PMID:18308860 GO_REF:0000107 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Itgb1 integrin subunit beta 1 involved_in ISO (PMID:18308860) RGD PMID:18308860 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itgb7 integrin subunit beta 7 involved_in ISO
IEA 		(PMID:18308860)
GO_REF:0000107 		RGD
Ensembl		 PMID:18308860 GO_REF:0000107 NCBI chr 7:133,347,927...133,364,955
Ensembl chr 7:133,347,960...133,364,876 		JBrowse link
G Jam2 junctional adhesion molecule 2 involved_in ISO
IEA 		(PMID:19740376)
GO_REF:0000107 		RGD
Ensembl		 PMID:19740376 GO_REF:0000107 NCBI chr11:23,830,820...23,880,071
Ensembl chr11:23,831,106...23,880,063 		JBrowse link
G Lep leptin IDA RGD PMID:20150963 RGD:5128596 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 involved_in ISO
IBA 		(PMID:18308860)
GO_REF:0000033 		RGD
GO_Central		 PMID:18308860 GO_REF:0000033 NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703 		JBrowse link
G Podxl2 podocalyxin-like 2 involved_in ISO
IEA
IBA 		(PMID:18606703)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:18606703 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:121,306,224...121,338,070
Ensembl chr 4:121,306,224...121,338,112 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:12082081) 		Ensembl
RGD		 PMID:12082081 GO_REF:0000107 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Sele selectin E involved_in ISO
IBA 		(PMID:18029551)
GO_REF:0000033 		RGD
GO_Central		 PMID:18029551 GO_REF:0000033 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sell selectin L involved_in ISO
IBA
IEA
ISS 		(PMID:28011641)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024 		RGD
GO_Central
Ensembl
UniProt		 PMID:28011641 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Selp selectin P involved_in
acts_upstream_of_or_within 		IEA
IBA
ISO
ISS 		GO_REF:0000107
GO_REF:0000033
MGI:1857245 (PMID:15956287)
GO_REF:0000024
(PMID:28011641) 		Ensembl
GO_Central
RGD
UniProt		 PMID:15956287 PMID:28011641 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Selplg selectin P ligand involved_in
acts_upstream_of_or_within 		ISO
IBA 		(PMID:25425738)
MGI:2176571 (PMID:15956287)
GO_REF:0000033 		RGD
GO_Central		 PMID:15956287 PMID:25425738 GO_REF:0000033 NCBI chr12:42,796,690...42,809,908
Ensembl chr12:42,796,580...42,812,585 		JBrowse link
G Spn sialophorin involved_in ISS
ISO 		GO_REF:0000024
(PMID:26700769) 		UniProt
RGD		 PMID:26700769 GO_REF:0000024 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO
IEA 		(PMID:10820279)
GO_REF:0000107 		RGD
Ensembl		 PMID:10820279 GO_REF:0000107 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 involved_in ISO
IEA 		(PMID:18308860), (PMID:2688898)
GO_REF:0000107 		RGD
Ensembl		 PMID:2688898 PMID:18308860 GO_REF:0000107 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
negative regulation of leukocyte tethering or rolling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO
IEA 		(PMID:18308860)
GO_REF:0000107 		RGD
Ensembl		 PMID:18308860 GO_REF:0000107 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686 		JBrowse link
G Ccl25 C-C motif chemokine ligand 25 involved_in ISO (PMID:18308860) RGD PMID:18308860 NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554 		JBrowse link
G Ccl28 C-C motif chemokine ligand 28 involved_in ISO
IEA 		(PMID:18308860)
GO_REF:0000107 		RGD
Ensembl		 PMID:18308860 GO_REF:0000107 NCBI chr 2:51,601,354...51,625,999
Ensembl chr 2:51,601,331...51,625,997 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 involved_in ISO
IEA 		(PMID:18308860)
GO_REF:0000107 		RGD
Ensembl		 PMID:18308860 GO_REF:0000107 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Sell selectin L IMP RGD PMID:7690324 RGD:597015766 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
positive regulation of leukocyte tethering or rolling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn1 calpain 1 IMP RGD PMID:21415394 RGD:13792556 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 acts_upstream_of_or_within ISO MGI:2158345 (PMID:9342361) RGD PMID:9342361 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Chst2 carbohydrate sulfotransferase 2 involved_in ISO (PMID:16227985) RGD PMID:16227985 NCBI chr 8:95,960,067...95,966,312
Ensembl chr 8:95,959,826...95,966,955 		JBrowse link
G Chst4 carbohydrate sulfotransferase 4 involved_in ISO (PMID:16227985) RGD PMID:16227985 NCBI chr19:37,993,471...38,002,123
Ensembl chr19:37,991,417...38,003,608 		JBrowse link
G Dcps decapping enzyme, scavenger involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 8:33,468,669...33,524,407
Ensembl chr 8:33,415,671...33,524,389 		JBrowse link
G Elane elastase, neutrophil expressed IMP RGD PMID:20860667 RGD:10450565 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Fut4 fucosyltransferase 4 involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:10894166), (PMID:11485743) 		Ensembl
UniProt
RGD		 PMID:10894166 PMID:11485743 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:11,586,721...11,590,682
Ensembl chr 8:11,586,721...11,590,682 		JBrowse link
G Fut7 fucosyltransferase 7 involved_in ISS
ISO 		GO_REF:0000024
(PMID:10894166), (PMID:11485743), (PMID:15843584) 		UniProt
RGD		 PMID:10894166 PMID:11485743 PMID:15843584 GO_REF:0000024 NCBI chr 3:8,237,687...8,242,273
Ensembl chr 3:8,239,384...8,242,260 		JBrowse link
G Gcnt1 glucosaminyl (N-acetyl) transferase 1 involved_in ISO (PMID:9881978) RGD PMID:9881978 NCBI chr 1:214,718,344...214,755,735
Ensembl chr 1:214,718,293...214,758,776 		JBrowse link
G Gp1ba glycoprotein Ib platelet subunit alpha IMP RGD PMID:12218538 RGD:150527852 NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774 		JBrowse link
G Itga4 integrin subunit alpha 4 IMP RGD PMID:9394821 RGD:9698423 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Pawr pro-apoptotic WT1 regulator IDA RGD PMID:12133973 RGD:9835372 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Ptafr platelet-activating factor receptor IMP RGD PMID:10528212 RGD:10041051 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Sele selectin E involved_in ISS
ISO 		GO_REF:0000024
(PMID:10894166) 		UniProt
RGD		 PMID:10894166 GO_REF:0000024 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Selp selectin P involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:10894166) 		UniProt
Ensembl
RGD		 PMID:10894166 GO_REF:0000024 GO_REF:0000107 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 involved_in ISO
ISS
IEA 		(PMID:25498912)
GO_REF:0000024
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:25498912 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:33,415,666...33,465,319
Ensembl chr 8:33,415,671...33,524,389 		JBrowse link
regulation of leukocyte tethering or rolling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fut7 fucosyltransferase 7 involved_in ISO (PMID:23192350) RGD PMID:23192350 NCBI chr 3:8,237,687...8,242,273
Ensembl chr 3:8,239,384...8,242,260 		JBrowse link
G Fut9 fucosyltransferase 9 involved_in ISO
ISS 		(PMID:23192350)
GO_REF:0000024 		RGD
UniProt		 PMID:23192350 GO_REF:0000024 NCBI chr 5:39,351,815...39,565,256
Ensembl chr 5:39,351,819...39,565,130 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    immune system process 3133
      leukocyte migration 408
        cellular extravasation 79
          leukocyte tethering or rolling 37
            negative regulation of leukocyte tethering or rolling 5
            positive regulation of leukocyte tethering or rolling 16
            regulation of leukocyte tethering or rolling + 22
Path 2
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cell motility 2027
        cell migration 1744
          leukocyte migration 408
            cellular extravasation 79
              leukocyte tethering or rolling 37
                negative regulation of leukocyte tethering or rolling 5
                positive regulation of leukocyte tethering or rolling 16
                regulation of leukocyte tethering or rolling + 22
paths to the root