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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of GTPase activity
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Accession:GO:0034260 term browser browse the term
Definition:Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
Comment:An example of this is P2xA in Dictyostelium (UniProt symbol Q86JM7) in PMID:24335649.
Synonyms:exact_synonym: down regulation of GTPase activity;   downregulation of GTPase activity;   negative regulation of guanosinetriphosphatase activity
 narrow_synonym: down regulation of Rab GTPase activity;   down regulation of Ras GTPase activity;   down regulation of Rho GTPase activity;   down regulation of regulation of Ran GTPase activity;   downregulation of Rab GTPase activity;   downregulation of Ras GTPase activity;   downregulation of Rho GTPase activity;   downregulation of regulation of Ran GTPase activity;   inhibition of GTPase activity;   inhibition of Rab GTPase activity;   inhibition of Ras GTPase activity;   inhibition of Rho GTPase activity;   inhibition of regulation of Ran GTPase activity;   negative regulation of Rab GTPase activity;   negative regulation of Ran GTPase activity;   negative regulation of Ras GTPase activity;   negative regulation of Rho GTPase activity
 alt_id: GO:0034259;   GO:0034261;   GO:1902264;   GO:1902881


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negative regulation of GTPase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 IDA RGD PMID:15870074 RGD:2325307 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Amot angiomotin acts_upstream_of_or_within ISO MGI:2656627 (PMID:17699752) RGD PMID:17699752 NCBI chr  X:108,982,399...109,041,265
Ensembl chr  X:108,984,022...109,041,272 		JBrowse link
G Arfgef1 ARF guanine nucleotide exchange factor 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15644318)		 UniProt
RGD		 PMID:15644318 GO_REF:0000024 NCBI chr 5:8,982,061...9,076,326
Ensembl chr 5:8,981,540...9,076,326 		JBrowse link
G Arl2 ARF like GTPase 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:10831612)		 UniProt
RGD		 PMID:10831612 GO_REF:0000024 NCBI chr 1:203,434,129...203,446,156
Ensembl chr 1:203,434,129...203,446,119 		JBrowse link
G Arrb1 arrestin, beta 1 IDA RGD PMID:1517224 RGD:631708 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 IDA RGD PMID:1517224 RGD:631708 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 acts_upstream_of_or_within ISO MGI:3055492 (PMID:23716571) RGD PMID:23716571 NCBI chr 8:59,731,912...59,765,408
Ensembl chr 8:59,731,912...59,765,607 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:20154697)
(PMID:19948740)		 UniProt
RGD		 PMID:19948740 PMID:20154697 GO_REF:0000024 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Gmip Gem-interacting protein involved_in ISO (PMID:12093360) RGD PMID:12093360 NCBI chr16:19,600,723...19,614,459
Ensembl chr16:19,600,723...19,614,027 		JBrowse link
G Gpsm1 G-protein signaling modulator 1 involved_in ISO (PMID:11024022) RGD PMID:11024022 NCBI chr 3:9,140,816...9,167,828
Ensembl chr 3:9,128,636...9,167,827 		JBrowse link
G Hras HRas proto-oncogene, GTPase involved_in ISO (PMID:23027131) RGD PMID:23027131 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Klre1 killer cell lectin like receptor E1 involved_in ISO (PMID:22585739) RGD PMID:22585739 NCBI chr 4:163,033,581...163,041,641
Ensembl chr 4:163,033,563...163,041,638 		JBrowse link
G Klrk1 killer cell lectin like receptor K1 involved_in ISO (PMID:22585739) RGD PMID:22585739 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459 		JBrowse link
G Lrch1 leucine rich repeats and calponin homology domain containing 1 involved_in ISO (PMID:28028151) RGD PMID:28028151 NCBI chr15:50,070,605...50,249,724
Ensembl chr15:50,071,947...50,249,657 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 acts_upstream_of_or_within ISO (PMID:22423108) RGD PMID:22423108 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Mkks MKKS centrosomal shuttling protein acts_upstream_of_or_within ISO MGI:3608879 (PMID:23716571) RGD PMID:23716571 NCBI chr 3:124,201,877...124,221,142
Ensembl chr 3:124,201,877...124,220,162 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 IDA RGD PMID:17662049 RGD:7240703 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Plxnb3 plexin B3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:20696765)		 UniProt
RGD		 PMID:20696765 GO_REF:0000024 NCBI chr  X:151,493,832...151,508,688
Ensembl chr  X:151,494,207...151,508,674 		JBrowse link
G Ptprn2 protein tyrosine phosphatase, receptor type N2 IDA RGD PMID:16413169 RGD:1625628 NCBI chr 6:137,439,572...138,191,575
Ensembl chr 6:137,439,540...138,191,575 		JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 acts_upstream_of_or_within ISO MGI:3613572 (PMID:26975711), (PMID:29921611) RGD PMID:26975711 PMID:29921611 NCBI chr 2:227,500,366...227,645,213
Ensembl chr 2:227,500,367...227,645,169 		JBrowse link
G Rcc2 regulator of chromosome condensation 2 involved_in ISO (PMID:25074804)
(PMID:19738201), (PMID:25074804)		 RGD PMID:19738201 PMID:25074804 NCBI chr 5:152,994,406...153,017,223
Ensembl chr 5:152,993,665...153,017,205 		JBrowse link
G Rdx radixin involved_in ISO (PMID:22467863) RGD PMID:22467863 NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678 		JBrowse link
G Rgn regucalcin IMP RGD PMID:11510494 RGD:9590205 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Rrp1b ribosomal RNA processing 1B involved_in ISO (PMID:18081427) RGD PMID:18081427 NCBI chr20:10,123,111...10,148,704
Ensembl chr20:10,123,125...10,147,928 		JBrowse link
G Sh3bp4 SH3-domain binding protein 4 involved_in ISS
ISO		 GO_REF:0000024
(PMID:22575674)		 UniProt
RGD		 PMID:22575674 GO_REF:0000024 NCBI chr 9:89,660,156...89,739,163
Ensembl chr 9:89,660,156...89,739,163 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within ISO (PMID:11585837) RGD PMID:11585837 NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within ISO (PMID:11585837) RGD PMID:11585837 NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:10761932)		 UniProt
RGD		 PMID:10761932 GO_REF:0000024 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
G Tsc1 TSC complex subunit 1 IMP RGD PMID:15611338 RGD:1601406 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674 		JBrowse link
G Ttc8 tetratricopeptide repeat domain 8 acts_upstream_of_or_within ISO (PMID:23716571) RGD PMID:23716571 NCBI chr 6:118,198,186...118,252,422
Ensembl chr 6:118,198,201...118,252,418 		JBrowse link
G Usp17la2 ubiquitin specific peptidase 17-like a2 involved_in ISO (PMID:19188362) RGD PMID:19188362 NCBI chr 1:159,151,417...159,155,192
Ensembl chr 1:159,151,432...159,155,192 		JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 acts_upstream_of_or_within ISO (PMID:27400149) RGD PMID:27400149 NCBI chr 4:153,128,334...153,253,905
Ensembl chr 4:153,128,334...153,253,905 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    negative regulation of biological process 5767
      negative regulation of GTPase activity 32
Path 2
Term Annotations click to browse term
  biological_process 20069
    biological regulation 13554
      regulation of molecular function 1784
        regulation of catalytic activity 1187
          regulation of hydrolase activity 520
            regulation of GTPase activity 186
              negative regulation of GTPase activity 32
paths to the root