Mkks (MKKS centrosomal shuttling protein) - Rat Genome Database

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Gene: Mkks (MKKS centrosomal shuttling protein) Rattus norvegicus
Analyze
Symbol: Mkks
Name: MKKS centrosomal shuttling protein
RGD ID: 1308814
Description: Predicted to have RNA polymerase II repressing transcription factor binding activity. Predicted to be involved in several processes, including blood vessel diameter maintenance; brain development; and regulation of actin filament organization. Predicted to localize to several cellular components, including microtubule organizing center; motile cilium; and nucleus. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 6; McKusick-Kaufman syndrome; congenital heart disease; and obesity. Orthologous to human MKKS (McKusick-Kaufman syndrome); INTERACTS WITH bisphenol A; flutamide; gentamycin.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: LOC311456; McKusick-Kaufman syndrome; McKusick-Kaufman syndrome protein; McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; MGC95109
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23124,201,877 - 124,221,142 (-)NCBI
Rnor_6.0 Ensembl3129,866,545 - 129,884,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03129,866,542 - 129,885,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03136,347,547 - 136,365,815 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43124,975,099 - 124,993,345 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13124,880,674 - 124,898,918 (-)NCBI
Celera3122,920,784 - 122,939,041 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:15772095   PMID:16170314   PMID:17379567   PMID:18032602   PMID:18299575   PMID:18317593   PMID:18443298   PMID:19150989   PMID:19195025   PMID:20080638   PMID:20193073  
PMID:20852044   PMID:22302990   PMID:22446187   PMID:23671934   PMID:23716571   PMID:28753627  


Genomics

Comparative Map Data
Mkks
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23124,201,877 - 124,221,142 (-)NCBI
Rnor_6.0 Ensembl3129,866,545 - 129,884,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03129,866,542 - 129,885,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03136,347,547 - 136,365,815 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43124,975,099 - 124,993,345 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13124,880,674 - 124,898,918 (-)NCBI
Celera3122,920,784 - 122,939,041 (-)NCBICelera
Cytogenetic Map3q36NCBI
MKKS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2010,401,009 - 10,434,222 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2010,420,546 - 10,420,737 (-)EnsemblGRCh38hg38GRCh38
GRCh382010,401,009 - 10,434,222 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372010,381,657 - 10,414,870 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362010,333,832 - 10,362,866 (-)NCBINCBI36hg18NCBI36
Build 342010,333,832 - 10,362,866NCBI
Celera2010,455,827 - 10,484,860 (-)NCBI
Cytogenetic Map20p12.2NCBI
HuRef2010,337,201 - 10,366,656 (-)NCBIHuRef
CHM1_12010,385,992 - 10,415,443 (-)NCBICHM1_1
Mkks
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392136,715,700 - 136,733,422 (-)NCBIGRCm39mm39
GRCm39 Ensembl2136,715,700 - 136,733,309 (-)Ensembl
GRCm382136,873,780 - 136,891,406 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2136,873,780 - 136,891,389 (-)EnsemblGRCm38mm10GRCm38
MGSCv372136,699,516 - 136,717,142 (-)NCBIGRCm37mm9NCBIm37
MGSCv362136,565,505 - 136,582,619 (-)NCBImm8
Celera2138,065,345 - 138,082,981 (-)NCBICelera
Cytogenetic Map2F3NCBI
Mkks
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541520,292,663 - 20,300,797 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541520,292,311 - 20,315,850 (-)NCBIChiLan1.0ChiLan1.0
MKKS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12010,351,246 - 10,380,503 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2010,351,309 - 10,366,863 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02010,346,252 - 10,380,180 (-)NCBIMhudiblu_PPA_v0panPan3
MKKS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12411,887,504 - 11,914,055 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2411,898,236 - 11,913,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2411,706,600 - 11,733,151 (+)NCBI
ROS_Cfam_1.02412,298,493 - 12,325,072 (+)NCBI
UMICH_Zoey_3.12411,905,962 - 11,932,517 (+)NCBI
UNSW_CanFamBas_1.02412,005,123 - 12,031,666 (+)NCBI
UU_Cfam_GSD_1.02412,348,068 - 12,374,624 (+)NCBI
Mkks
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640160,657,713 - 160,683,085 (+)NCBI
SpeTri2.0NW_0049364859,089,118 - 9,114,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MKKS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1719,340,977 - 19,362,871 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11719,341,024 - 19,363,007 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21721,817,124 - 21,839,355 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MKKS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,728,295 - 27,757,569 (+)NCBI
ChlSab1.1 Ensembl227,736,537 - 27,757,237 (+)Ensembl
Vero_WHO_p1.0NW_02366607116,818,364 - 16,851,748 (-)NCBI
Mkks
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474111,323,935 - 11,447,669 (-)NCBI

Position Markers
RH143044  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23124,210,270 - 124,210,416 (+)MAPPER
Rnor_6.03129,874,936 - 129,875,081NCBIRnor6.0
Rnor_5.03136,355,941 - 136,356,086UniSTSRnor5.0
RGSC_v3.43124,983,493 - 124,983,638UniSTSRGSC3.4
Celera3122,929,178 - 122,929,323UniSTS
RH 3.4 Map31087.3UniSTS
Cytogenetic Map3q36UniSTS
RH137010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23124,201,932 - 124,202,105 (+)MAPPER
Rnor_6.03129,866,598 - 129,866,770NCBIRnor6.0
Rnor_5.03136,347,603 - 136,347,775UniSTSRnor5.0
RGSC_v3.43124,975,155 - 124,975,327UniSTSRGSC3.4
Celera3122,920,840 - 122,921,012UniSTS
RH 3.4 Map31077.3UniSTS
Cytogenetic Map3q36UniSTS
RH137166  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23124,208,718 - 124,208,907 (+)MAPPER
Rnor_6.03129,873,384 - 129,873,572NCBIRnor6.0
Rnor_5.03136,354,389 - 136,354,577UniSTSRnor5.0
RGSC_v3.43124,981,941 - 124,982,129UniSTSRGSC3.4
Celera3122,927,626 - 122,927,814UniSTS
Cytogenetic Map3q36UniSTS
MARC_17187-17188:1021314368:3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23124,207,864 - 124,208,324 (+)MAPPER
Rnor_6.03129,872,530 - 129,872,989NCBIRnor6.0
Rnor_5.03136,353,535 - 136,353,994UniSTSRnor5.0
RGSC_v3.43124,981,087 - 124,981,546UniSTSRGSC3.4
Celera3122,926,772 - 122,927,231UniSTS
Cytogenetic Map3q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)339248391140271184Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)381136227154416635Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)388910015133910015Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)394788365139788365Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)397009185142009185Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3101058963146058963Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3102152812155263151Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3102466149147466149Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3114376250159376250Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3117303473141971336Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3119471263164471263Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3120917788141971336Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3120917788141971336Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3125848628170848628Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3126575595153412619Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3126575595165355668Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128986468173986468Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3129787213177699992Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:170
Count of miRNA genes:120
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000009540
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 39 30 18 30 1 74 35 34 11
Low 8 18 11 1 11 8 10 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009540   ⟹   ENSRNOP00000009540
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3129,866,545 - 129,884,810 (-)Ensembl
RefSeq Acc Id: NM_001008353   ⟹   NP_001008354
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23124,201,877 - 124,220,153 (-)NCBI
Rnor_6.03129,866,542 - 129,884,810 (-)NCBI
Rnor_5.03136,347,547 - 136,365,815 (-)NCBI
RGSC_v3.43124,975,099 - 124,993,345 (-)RGD
Celera3122,920,784 - 122,939,041 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762254   ⟹   XP_008760476
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23124,202,382 - 124,221,142 (-)NCBI
Rnor_6.03129,867,047 - 129,885,213 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001008354 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760476 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83863 (Get FASTA)   NCBI Sequence Viewer  
  EDL80305 (Get FASTA)   NCBI Sequence Viewer  
  EDL80306 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001008354   ⟸   NM_001008353
- UniProtKB: Q5XI30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760476   ⟸   XM_008762254
- Peptide Label: isoform X1
- UniProtKB: Q5XI30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009540   ⟸   ENSRNOT00000009540

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692465
Promoter ID:EPDNEW_R2989
Type:initiation region
Name:Mkks_1
Description:McKusick-Kaufman syndrome
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03129,884,817 - 129,884,877EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 136350427 136350428 G A snv DOB/Oda (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308814 AgrOrtholog
Ensembl Genes ENSRNOG00000006705 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009540 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009540 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.560.10 UniProtKB/TrEMBL
  3.30.260.10 UniProtKB/TrEMBL
  3.50.7.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127425 IMAGE-MGC_LOAD
InterPro Cpn60/TCP-1 UniProtKB/TrEMBL
  GroEL-like_apical_dom UniProtKB/TrEMBL
  GROEL-like_equatorial UniProtKB/TrEMBL
  MKKS UniProtKB/TrEMBL
  TCP-1-like_intermed_sf UniProtKB/TrEMBL
KEGG Report rno:311456 UniProtKB/TrEMBL
MGC_CLONE MGC:95109 IMAGE-MGC_LOAD
NCBI Gene 311456 ENTREZGENE
PANTHER PTHR46787 UniProtKB/TrEMBL
Pfam Cpn60_TCP1 UniProtKB/TrEMBL
PhenoGen Mkks PhenoGen
Superfamily-SCOP SSF48592 UniProtKB/TrEMBL
  SSF52029 UniProtKB/TrEMBL
UniProt Q5XI30 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Mkks  MKKS centrosomal shuttling protein  Mkks  McKusick-Kaufman syndrome  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Mkks  McKusick-Kaufman syndrome  Mkks  McKusick-Kaufman syndrome protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Mkks  McKusick-Kaufman syndrome protein  Mkks_predicted  McKusick-Kaufman syndrome protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mkks_predicted  McKusick-Kaufman syndrome protein (predicted)      Symbol and Name status set to approved 70820 APPROVED