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ONTOLOGY REPORT - ANNOTATIONS

Term:plasminogen activation
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Accession:GO:0031639 term browser browse the term
Definition:The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
Synonyms:exact_synonym: cleavage of plasminogen to plasmin
 only_in_taxon: NCBITaxon:7742 ! Vertebrata


show annotations for term's descendants           Sort by:
plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoh apolipoprotein H involved_in ISO
IEA		 (PMID:16480936)
GO_REF:0000107		 RGD
Ensembl		 PMID:16480936 GO_REF:0000107 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within ISO MGI:3027024 (PMID:16407971) RGD PMID:16407971 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G F11 coagulation factor XI involved_in ISO (PMID:89876) RGD PMID:89876 NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437 		JBrowse link
G Fga fibrinogen alpha chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgb fibrinogen beta chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgg fibrinogen gamma chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G H2bc1 H2B clustered histone 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:17690254)		 Ensembl
RGD		 PMID:17690254 GO_REF:0000107 NCBI chr17:41,172,041...41,172,510
Ensembl chr17:41,171,903...41,176,782
Ensembl chr17:41,171,903...41,176,782 		JBrowse link
G Klkb1 kallikrein B1 involved_in ISO
IEA		 (PMID:89876)
GO_REF:0000107		 RGD
Ensembl		 PMID:89876 GO_REF:0000107 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 involved_in ISO (PMID:11130727) RGD PMID:11130727 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Plat plasminogen activator, tissue type involved_in IDA
ISO
IEA
IBA		 (PMID:12694198), (PMID:17849409), (PMID:24196407)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033		 RGD
InterPro
Ensembl
GO_Central		 PMID:12694198 PMID:17849409 PMID:24196407 PMID:8343497 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:11537479 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase involved_in ISO
IBA
IEA		 (PMID:25978044)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:25978044 GO_REF:0000033 GO_REF:0000107 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Tmprss9 transmembrane serine protease 9 acts_upstream_of_or_within ISO (PMID:16872279) RGD PMID:16872279 NCBI chr 7:8,810,321...8,831,177
Ensembl chr 7:8,810,320...8,831,177 		JBrowse link
negative regulation of plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpb2 carboxypeptidase B2 IMP RGD PMID:23369837 RGD:7243115 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Ctsz cathepsin Z involved_in ISO
IEA		 (PMID:19433310)
GO_REF:0000107		 RGD
Ensembl		 PMID:19433310 GO_REF:0000107 NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645 		JBrowse link
G Serpine1 serpin family E member 1 involved_in IEA
ISO
IBA		 GO_REF:0000107
(PMID:19855083)
GO_REF:0000033
(PMID:18835034), (PMID:19855083), (PMID:8508955)		 Ensembl
RGD
GO_Central		 PMID:8508955 PMID:18835034 PMID:19855083 GO_REF:0000033 GO_REF:0000107 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpine2 serpin family E member 2 involved_in ISO
IBA
IEA		 (PMID:19855083)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:19855083 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Serpinf2 serpin family F member 2 involved_in ISO (PMID:134998) RGD PMID:134998 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243 		JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:6438154) RGD PMID:6438154 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
positive regulation of plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 involved_in ISO (PMID:9836589) RGD PMID:9836589 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Clec3b C-type lectin domain family 3, member B involved_in ISS
ISO		 GO_REF:0000024
(PMID:12694198)		 UniProt
RGD		 PMID:12694198 GO_REF:0000024 NCBI chr 8:122,810,120...122,815,837
Ensembl chr 8:122,810,149...122,815,835 		JBrowse link
G Eno1 enolase 1 involved_in ISO (PMID:12666133) RGD PMID:12666133 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G F12 coagulation factor XII involved_in ISO
IEA		 (PMID:89876)
GO_REF:0000107		 RGD
Ensembl		 PMID:89876 GO_REF:0000107 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G Hpn hepsin involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:16908524)		 UniProt
Ensembl
RGD		 PMID:16908524 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Meltf melanotransferrin involved_in ISO (PMID:16713448) RGD PMID:16713448 NCBI chr11:68,884,446...68,906,300
Ensembl chr11:68,884,446...68,906,300 		JBrowse link
G Plgrkt plasminogen receptor with a C-terminal lysine involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:19897580)		 GO_Central
RGD		 PMID:19897580 GO_REF:0000033 NCBI chr 1:227,099,005...227,111,277
Ensembl chr 1:227,099,015...227,111,194 		JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 IDA RGD PMID:11027681 RGD:67924 NCBI chr 4:120,932,486...120,967,400
Ensembl chr 4:120,932,417...121,029,384 		JBrowse link
G S100a10 S100 calcium binding protein A10 involved_in ISO
IEA		 (PMID:9836589)
GO_REF:0000107		 RGD
Ensembl		 PMID:9836589 GO_REF:0000107 NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11949
        macromolecule metabolic process 9808
          protein metabolic process 5296
            protein maturation 643
              protein processing 269
                zymogen activation 68
                  plasminogen activation 27
                    negative regulation of plasminogen activation 6
                    positive regulation of plasminogen activation 9
                    regulation of plasminogen activation + 15
Path 2
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11949
        biosynthetic process 8469
          macromolecule biosynthetic process 7494
            gene expression 7050
              protein maturation 643
                protein processing 269
                  zymogen activation 68
                    plasminogen activation 27
                      negative regulation of plasminogen activation 6
                      positive regulation of plasminogen activation 9
                      regulation of plasminogen activation + 15
paths to the root