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ONTOLOGY REPORT - ANNOTATIONS


Term:zymogen activation
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Accession:GO:0031638 term browser browse the term
Definition:The proteolytic processing of an inactive enzyme to an active form.
Synonyms:exact_synonym: zymogen activation by proteolytic cleavage



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zymogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1r complement C1r involved_in IBA
ISO
PMID:21873635
(PMID:20178990)
RGD PMID:20178990 PMID:21873635 RGD:13792537 NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
JBrowse link
G C1rl complement C1r subcomponent like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:157,394,183...157,410,771
Ensembl chr 4:157,394,200...157,410,134
JBrowse link
G Cd5l Cd5 molecule-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
JBrowse link
G Ctsh cathepsin H involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:20435891)
(MGI:4838939|PMID:20435891)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:20435891 GO_REF:0000024 GO_REF:0000107 MGI:4838939 NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824
JBrowse link
G Ctsl cathepsin L involved_in ISO
ISS
(PMID:9468501)
GO_REF:0000024
RGD
UniProt
PMID:9468501 GO_REF:0000024 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Dcbld1 discoidin, CUB and LCCL domain containing 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:31,618,556...31,711,697
Ensembl chr20:31,618,542...31,711,692
JBrowse link
G ENSRNOG00000069479 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:94,459,406...94,464,664 JBrowse link
G F10 coagulation factor X involved_in ISO (PMID:14982929) RGD PMID:14982929 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F12 coagulation factor XII involved_in IEA
ISO
IBA
GO_REF:0000107
(PMID:6793628), (PMID:89876)
(PMID:18725990)
PMID:21873635
(PMID:18725990), (PMID:6793628), (PMID:89876)
Ensembl
RGD
PMID:89876 PMID:6793628 PMID:18725990 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
JBrowse link
G F2 coagulation factor II involved_in ISO (PMID:22457833) RGD PMID:22457833 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F5 coagulation factor V involved_in ISO (PMID:14982929) RGD PMID:14982929 NCBI chr13:76,513,463...76,583,106
Ensembl chr13:76,513,255...76,582,317
JBrowse link
G F9 coagulation factor IX involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:8632006)
PMID:21873635
(PMID:2592373)
UniProt
RGD
PMID:2592373 PMID:8632006 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) involved_in ISO (PMID:11799113), (PMID:9130696) RGD PMID:9130696 PMID:11799113 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:23682772)
UniProt
RGD
PMID:23682772 GO_REF:0000024 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Hgfac HGF activator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:75,707,588...75,714,182
Ensembl chr14:75,707,591...75,714,278
JBrowse link
G Hp haptoglobin involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Klk1 kallikrein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:94,642,722...94,646,714
Ensembl chr 1:94,642,687...94,646,754
JBrowse link
G Klk1b3 kallikrein 1-related peptidase B3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:94,709,105...94,713,308
Ensembl chr 1:94,709,105...94,713,308
JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
JBrowse link
G Klk1c12 kallikrein 1-related peptidase C12 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:94,378,103...94,382,140
Ensembl chr 1:94,378,054...94,382,176
JBrowse link
G Klk1c2 kallikrein 1-related peptidase C2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:94,492,332...94,496,480
Ensembl chr 1:94,492,332...94,496,481
JBrowse link
G Klk1c3 kallikrein 1-related peptidase C3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:94,671,636...94,675,417
Ensembl chr 1:94,671,618...94,675,417
JBrowse link
G Klk1c6 kallikrein 1-related peptidase C6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:94,467,639...94,475,806
Ensembl chr 1:94,467,672...94,475,806
JBrowse link
G Klk1c8 kallikrein 1-related peptidase C8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:94,547,774...94,552,287
Ensembl chr 1:94,547,774...94,551,636
JBrowse link
G Klk1c9 kallikrein 1-related peptidase C9 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:94,597,359...94,601,245
Ensembl chr 1:94,597,359...94,601,245
JBrowse link
G Klkb1 kallikrein B1 involved_in ISO (PMID:874082) RGD PMID:874082 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
JBrowse link
G Mmp14 matrix metallopeptidase 14 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:20666777)
MGI:2386246 (MGI:3527919|PMID:15572153)
PMID:21873635
RGD PMID:15572153 PMID:20666777 PMID:21873635 MGI:3527919, RGD:13792537 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Oma1 OMA1 zinc metallopeptidase involved_in ISS
ISO
GO_REF:0000024
(MGI:5560823|PMID:24550258), (MGI:6436376|PMID:24719224)
UniProt
RGD
PMID:24550258 PMID:24719224 GO_REF:0000024 MGI:5560823 MGI:6436376 NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980
JBrowse link
G Prss12 serine protease 12 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3698899|PMID:17223089)
RGD PMID:17223089 PMID:21873635 MGI:3698899, RGD:13792537 NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126
JBrowse link
G Prss3 serine protease 3 involved_in ISO (PMID:6698368) RGD PMID:6698368 NCBI chr 4:70,203,088...70,206,562
Ensembl chr 4:70,203,088...70,206,562
JBrowse link
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:20666777) RGD PMID:20666777 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878
JBrowse link
activation of cysteine-type endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 involved_in ISO (PMID:10206961) RGD PMID:10206961 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Asph aspartate-beta-hydroxylase involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr 5:22,603,879...22,814,107
Ensembl chr 5:22,603,486...22,813,876
JBrowse link
G Bad BCL2-associated agonist of cell death involved_in ISO
IBA
(PMID:18387192)
PMID:21873635
RGD PMID:18387192 PMID:21873635 RGD:13792537 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Casp6 caspase 6 involved_in ISO (PMID:9922454) RGD PMID:9922454 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp8 caspase 8 involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 involved_in ISO (PMID:10206961), (PMID:27882936) RGD PMID:10206961 PMID:27882936 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cideb cell death-inducing DFFA-like effector b involved_in ISO (PMID:12595532) RGD PMID:12595532 NCBI chr15:29,252,203...29,256,759
Ensembl chr15:29,252,213...29,256,605
JBrowse link
G Cycs cytochrome c, somatic involved_in ISO (PMID:10206961) RGD PMID:10206961 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 involved_in IBA
ISO
PMID:21873635
(PMID:18387192)
RGD PMID:18387192 PMID:21873635 RGD:13792537 NCBI chr10:30,621,318...30,741,113
Ensembl chr10:30,621,318...30,741,113
JBrowse link
G Fadd Fas associated via death domain involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Lgmn legumain involved_in ISO
IEA
(PMID:18374643), (PMID:9821970)
GO_REF:0000107
RGD
Ensembl
PMID:9821970 PMID:18374643 GO_REF:0000107 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 involved_in ISO UniProtKB:P10749|UniProtKB:P29466 (PMID:15882992) RGD PMID:15882992 NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248
JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 acts_upstream_of_or_within ISO (MGI:6453663|PMID:30248149) RGD PMID:30248149 MGI:6453663 NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113
JBrowse link
G Pawr pro-apoptotic WT1 regulator IMP RGD PMID:10349840 RGD:9835366 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Perp p53 apoptosis effector related to PMP22 involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (MGI:5491128|PMID:23302887) RGD PMID:23302887 MGI:5491128 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 involved_in ISO (PMID:11821383) RGD PMID:11821383 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Tbc1d10a TBC1 domain family, member 10a involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr14:79,051,822...79,083,603
Ensembl chr14:79,055,432...79,083,600
JBrowse link
negative regulation of plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpb2 carboxypeptidase B2 IMP RGD PMID:23369837 RGD:7243115 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556
JBrowse link
G Ctsz cathepsin Z involved_in ISO (PMID:19433310) RGD PMID:19433310 NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645
JBrowse link
G Serpine1 serpin family E member 1 involved_in IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(MGI:4418017|PMID:19855083)
(PMID:18835034), (PMID:19855083), (PMID:8508955)
Ensembl
RGD
PMID:8508955 PMID:18835034 PMID:19855083 PMID:21873635 GO_REF:0000107 MGI:4418017, RGD:13792537 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serpine2 serpin family E member 2 involved_in ISO
IBA
IEA
(PMID:19855083)
PMID:21873635
GO_REF:0000107
(MGI:4418017|PMID:19855083)
RGD
Ensembl
PMID:19855083 PMID:21873635 GO_REF:0000107 MGI:4418017, RGD:13792537 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Serpinf2 serpin family F member 2 involved_in ISO (PMID:134998) RGD PMID:134998 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243
JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:6438154) RGD PMID:6438154 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoh apolipoprotein H involved_in ISO
IEA
(PMID:16480936)
GO_REF:0000107
RGD
Ensembl
PMID:16480936 GO_REF:0000107 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within ISO MGI:3027024 (MGI:3614236|PMID:16407971) RGD PMID:16407971 MGI:3614236 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G F11 coagulation factor XI involved_in ISO (PMID:89876) RGD PMID:89876 NCBI chr16:46,986,107...47,009,015
Ensembl chr16:46,986,107...47,008,437
JBrowse link
G Fga fibrinogen alpha chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgg fibrinogen gamma chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G H2bc1 H2B clustered histone 1 acts_upstream_of_or_within ISO (MGI:3847621|PMID:17690254) RGD PMID:17690254 MGI:3847621 NCBI chr17:41,172,041...41,172,510
Ensembl chr17:41,171,903...41,176,782
Ensembl chr17:41,171,903...41,176,782
JBrowse link
G Klkb1 kallikrein B1 involved_in ISO
IEA
(PMID:89876)
GO_REF:0000107
RGD
Ensembl
PMID:89876 GO_REF:0000107 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
JBrowse link
G Pgk1 phosphoglycerate kinase 1 involved_in ISO (PMID:11130727) RGD PMID:11130727 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Plat plasminogen activator, tissue type involved_in IDA
IEA
ISO
IBA
GO_REF:0000002
(PMID:12694198), (PMID:17849409), (PMID:24196407)
PMID:21873635
InterPro
RGD
PMID:12694198 PMID:17849409 PMID:24196407 PMID:8343497 PMID:21873635 GO_REF:0000002, RGD:11537479, RGD:13792537 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plau plasminogen activator, urokinase involved_in ISO
IBA
IEA
(PMID:25978044)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:25978044 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Tmprss9 transmembrane serine protease 9 acts_upstream_of_or_within ISO (MGI:3694407|PMID:16872279) RGD PMID:16872279 MGI:3694407 NCBI chr 7:8,810,320...8,834,914
Ensembl chr 7:8,810,320...8,831,177
JBrowse link
positive regulation of plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 involved_in ISO (PMID:9836589) RGD PMID:9836589 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Clec3b C-type lectin domain family 3, member B involved_in ISS
ISO
GO_REF:0000024
(MGI:5447625|PMID:12694198)
UniProt
RGD
PMID:12694198 GO_REF:0000024 MGI:5447625 NCBI chr 8:122,810,091...122,817,039
Ensembl chr 8:122,810,149...122,815,835
JBrowse link
G Eno1 enolase 1 involved_in ISO (PMID:12666133) RGD PMID:12666133 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G F12 coagulation factor XII involved_in ISO
IEA
(PMID:89876)
GO_REF:0000107
RGD
Ensembl
PMID:89876 GO_REF:0000107 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
JBrowse link
G Hpn hepsin involved_in ISS
ISO
GO_REF:0000024
(PMID:16908524)
UniProt
RGD
PMID:16908524 GO_REF:0000024 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Meltf melanotransferrin involved_in ISO (PMID:16713448) RGD PMID:16713448 NCBI chr11:68,884,446...68,906,300
Ensembl chr11:68,884,446...68,906,300
JBrowse link
G Plgrkt plasminogen receptor with a C-terminal lysine involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:4437195|PMID:19897580)
RGD PMID:19897580 PMID:21873635 MGI:4437195, RGD:13792537 NCBI chr 1:227,099,005...227,111,277
Ensembl chr 1:227,099,015...227,111,194
JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 IDA RGD PMID:11027681 RGD:67924 NCBI chr 4:120,932,486...120,967,400
Ensembl chr 4:120,932,417...121,029,384
JBrowse link
G S100a10 S100 calcium binding protein A10 involved_in ISO (PMID:9836589) RGD PMID:9836589 NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661
JBrowse link
trypsinogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cuzd1 CUB and zona pellucida-like domains 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:2447912|PMID:12401800)
UniProt
RGD
PMID:12401800 GO_REF:0000024 MGI:2447912 NCBI chr 1:186,089,422...186,130,536
Ensembl chr 1:186,089,423...186,102,546
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18872
    metabolic process 11588
      primary metabolic process 10391
        protein metabolic process 5861
          proteolysis 1868
            protein processing 267
              zymogen activation 76
                activation of cysteine-type endopeptidase activity 19
                plasminogen activation + 27
                trypsinogen activation 1
                zymogen activation in another organism + 0
Path 2
Term Annotations click to browse term
  biological_process 18872
    metabolic process 11588
      organic substance metabolic process 11147
        macromolecule metabolic process 9583
          protein metabolic process 5861
            proteolysis 1868
              protein processing 267
                zymogen activation 76
                  activation of cysteine-type endopeptidase activity 19
                  plasminogen activation + 27
                  trypsinogen activation 1
                  zymogen activation in another organism + 0
paths to the root