ONTOLOGY REPORT - ANNOTATIONS |
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Term: | zymogen activation |
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Accession: | GO:0031638
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browse the term
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Definition: | The proteolytic processing of an inactive enzyme to an active form. |
Synonyms: | exact_synonym: | zymogen activation by proteolytic cleavage |
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C1r |
complement C1r |
involved_in |
ISO IBA |
(PMID:20178990) GO_REF:0000033 |
RGD GO_Central |
PMID:20178990 |
GO_REF:0000033 |
NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
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C1rl |
complement C1r subcomponent like |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 4:157,394,183...157,410,771
Ensembl chr 4:157,394,200...157,410,134
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Cd5l |
Cd5 molecule-like |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
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Ctsh |
cathepsin H |
involved_in |
ISS ISO IEA |
GO_REF:0000024 (PMID:20435891) GO_REF:0000107 |
UniProt RGD Ensembl |
PMID:20435891 |
GO_REF:0000024 GO_REF:0000107 |
NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824
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Ctsl |
cathepsin L |
involved_in |
ISO ISS |
(PMID:9468501) GO_REF:0000024 |
RGD UniProt |
PMID:9468501 |
GO_REF:0000024 |
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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F12 |
coagulation factor XII |
involved_in |
IEA IBA ISO |
GO_REF:0000107 GO_REF:0000033 (PMID:18725990), (PMID:6793628), (PMID:89876) |
Ensembl GO_Central RGD |
PMID:89876 PMID:6793628 PMID:18725990 |
GO_REF:0000033 GO_REF:0000107 |
NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
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F9 |
coagulation factor IX |
involved_in |
ISS ISO IEA IBA |
GO_REF:0000024 (PMID:2592373) GO_REF:0000107 GO_REF:0000033 |
UniProt RGD Ensembl GO_Central |
PMID:2592373 |
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 |
NCBI chr X:138,352,334...138,396,835
Ensembl chr X:138,352,298...138,396,835
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Fcrl1 |
Fc receptor-like 1 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 2:172,809,442...172,829,780
Ensembl chr 2:172,790,934...172,829,753
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Furin |
furin (paired basic amino acid cleaving enzyme) |
involved_in |
ISO IEA |
(PMID:11799113), (PMID:9130696) GO_REF:0000107 |
RGD Ensembl |
PMID:9130696 PMID:11799113 |
GO_REF:0000107 |
NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
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Ggt1 |
gamma-glutamyltransferase 1 |
involved_in |
ISS ISO |
GO_REF:0000024 (PMID:23682772) |
UniProt RGD |
PMID:23682772 |
GO_REF:0000024 |
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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Hgfac |
HGF activator |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr14:75,707,588...75,714,182
Ensembl chr14:75,707,591...75,714,278
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Klk1 |
kallikrein 1 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754
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Klk1b3 |
kallikrein 1-related peptidase B3 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 1:94,709,105...94,713,308
Ensembl chr 1:94,709,105...94,713,308
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Klk1c10 |
kallikrein 1-related peptidase C10 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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Klk1c12 |
kallikrein 1-related peptidase C12 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 1:94,378,103...94,382,140
Ensembl chr 1:94,378,054...94,382,176
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Klk1c2 |
kallikrein 1-related peptidase C2 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 1:94,492,332...94,496,480
Ensembl chr 1:94,492,332...94,496,481
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Klk1c3 |
kallikrein 1-related peptidase C3 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 1:94,671,636...94,675,417
Ensembl chr 1:94,671,618...94,675,417
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Klk1c6 |
kallikrein 1-related peptidase C6 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 1:94,467,626...94,475,842
Ensembl chr 1:94,467,672...94,475,806
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Klk1c8 |
kallikrein 1-related peptidase C8 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 1:94,547,774...94,552,287
Ensembl chr 1:94,547,774...94,551,636
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Klk1c9 |
kallikrein 1-related peptidase C9 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 1:94,597,359...94,601,245
Ensembl chr 1:94,597,359...94,601,245
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Masp1 |
MBL associated serine protease 1 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
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Mmp14 |
matrix metallopeptidase 14 |
involved_in acts_upstream_of_or_within |
ISO IBA |
(PMID:20666777) MGI:2386246 (PMID:15572153) GO_REF:0000033 |
RGD GO_Central |
PMID:15572153 PMID:20666777 |
GO_REF:0000033 |
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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Oma1 |
OMA1 zinc metallopeptidase |
involved_in |
ISS ISO IEA |
GO_REF:0000024 (PMID:24550258), (PMID:24719224) GO_REF:0000107 |
UniProt RGD Ensembl |
PMID:24550258 PMID:24719224 |
GO_REF:0000024 GO_REF:0000107 |
NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980
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Or12j2 |
olfactory receptor family 12 subfamily J member 2 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 1:195,209,804...195,210,721
Ensembl chr 1:195,208,141...195,212,120
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Prss12 |
serine protease 12 |
involved_in acts_upstream_of_or_within |
IBA ISO |
GO_REF:0000033 (PMID:17223089) |
GO_Central RGD |
PMID:17223089 |
GO_REF:0000033 |
NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126
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Prss3 |
serine protease 3 |
involved_in |
ISO |
(PMID:6698368) |
RGD |
PMID:6698368 |
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NCBI chr 4:70,203,088...70,206,562
Ensembl chr 4:70,203,088...70,206,562
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Prss3b |
protease, serine, 3B |
involved_in |
IEA |
GO_REF:0000107 |
Ensembl |
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GO_REF:0000107 |
NCBI chr 4:69,871,810...69,875,518
Ensembl chr 4:69,871,797...69,875,549
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Vsir |
V-set immunoregulatory receptor |
involved_in |
ISO |
(PMID:20666777) |
RGD |
PMID:20666777 |
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NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878
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Asph |
aspartate-beta-hydroxylase |
involved_in |
ISO |
(PMID:18387192) |
RGD |
PMID:18387192 |
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NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876
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Bad |
BCL2-associated agonist of cell death |
involved_in |
ISO |
(PMID:18387192) |
RGD |
PMID:18387192 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bak1 |
BCL2-antagonist/killer 1 |
involved_in |
ISO |
(PMID:18387192) |
RGD |
PMID:18387192 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Casp8 |
caspase 8 |
involved_in |
ISO |
(PMID:18387192) |
RGD |
PMID:18387192 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Cyfip2 |
cytoplasmic FMR1 interacting protein 2 |
involved_in |
ISO |
(PMID:18387192) |
RGD |
PMID:18387192 |
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NCBI chr10:30,621,318...30,741,113
Ensembl chr10:30,621,318...30,741,113
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Fadd |
Fas associated via death domain |
involved_in |
ISO |
(PMID:18387192) |
RGD |
PMID:18387192 |
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NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Lgmn |
legumain |
involved_in |
ISO |
(PMID:9821970) |
RGD |
PMID:9821970 |
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NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
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Nlrc4 |
NLR family, CARD domain containing 4 |
involved_in |
ISO |
UniProtKB:P10749|UniProtKB:P29466 (PMID:15882992) |
RGD |
PMID:15882992 |
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NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248
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Nlrp6 |
NLR family, pyrin domain containing 6 |
acts_upstream_of_or_within |
ISO |
(PMID:30248149) |
RGD |
PMID:30248149 |
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NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113
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Perp |
p53 apoptosis effector related to PMP22 |
involved_in |
ISO |
(PMID:18387192) |
RGD |
PMID:18387192 |
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NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
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Pycard |
PYD and CARD domain containing |
involved_in |
ISO |
(PMID:23302887) |
RGD |
PMID:23302887 |
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NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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Ripk2 |
receptor-interacting serine-threonine kinase 2 |
involved_in |
ISO |
(PMID:11821383) |
RGD |
PMID:11821383 |
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NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
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Tbc1d10a |
TBC1 domain family, member 10a |
involved_in |
ISO |
(PMID:18387192) |
RGD |
PMID:18387192 |
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NCBI chr14:79,051,822...79,083,603
Ensembl chr14:79,055,432...79,083,600
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Cpb2 |
carboxypeptidase B2 |
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IMP |
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RGD |
PMID:23369837 |
RGD:7243115 |
NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556
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Ctsz |
cathepsin Z |
involved_in |
ISO IEA |
(PMID:19433310) GO_REF:0000107 |
RGD Ensembl |
PMID:19433310 |
GO_REF:0000107 |
NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645
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Serpine1 |
serpin family E member 1 |
involved_in |
IEA ISO IBA |
GO_REF:0000107 (PMID:19855083) GO_REF:0000033 (PMID:18835034), (PMID:19855083), (PMID:8508955) |
Ensembl RGD GO_Central |
PMID:8508955 PMID:18835034 PMID:19855083 |
GO_REF:0000033 GO_REF:0000107 |
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Serpine2 |
serpin family E member 2 |
involved_in |
ISO IBA IEA |
(PMID:19855083) GO_REF:0000033 GO_REF:0000107 |
RGD GO_Central Ensembl |
PMID:19855083 |
GO_REF:0000033 GO_REF:0000107 |
NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
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Serpinf2 |
serpin family F member 2 |
involved_in |
ISO |
(PMID:134998) |
RGD |
PMID:134998 |
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NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243
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Thbs1 |
thrombospondin 1 |
involved_in |
ISO |
(PMID:6438154) |
RGD |
PMID:6438154 |
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NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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Apoh |
apolipoprotein H |
involved_in |
ISO IEA |
(PMID:16480936) GO_REF:0000107 |
RGD Ensembl |
PMID:16480936 |
GO_REF:0000107 |
NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329
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Dhcr24 |
24-dehydrocholesterol reductase |
acts_upstream_of_or_within |
ISO |
MGI:3027024 (PMID:16407971) |
RGD |
PMID:16407971 |
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NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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F11 |
coagulation factor XI |
involved_in |
ISO |
(PMID:89876) |
RGD |
PMID:89876 |
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NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437
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Fga |
fibrinogen alpha chain |
involved_in |
ISO |
(PMID:16846481) |
RGD |
PMID:16846481 |
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NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
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Fgb |
fibrinogen beta chain |
involved_in |
ISO |
(PMID:16846481) |
RGD |
PMID:16846481 |
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NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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Fgg |
fibrinogen gamma chain |
involved_in |
ISO |
(PMID:16846481) |
RGD |
PMID:16846481 |
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NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
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H2bc1 |
H2B clustered histone 1 |
involved_in acts_upstream_of_or_within |
IEA ISO |
GO_REF:0000107 (PMID:17690254) |
Ensembl RGD |
PMID:17690254 |
GO_REF:0000107 |
NCBI chr17:41,172,041...41,172,510
Ensembl chr17:41,171,903...41,176,782 Ensembl chr17:41,171,903...41,176,782
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Klkb1 |
kallikrein B1 |
involved_in |
ISO IEA |
(PMID:89876) GO_REF:0000107 |
RGD Ensembl |
PMID:89876 |
GO_REF:0000107 |
NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
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Pgk1 |
phosphoglycerate kinase 1 |
involved_in |
ISO |
(PMID:11130727) |
RGD |
PMID:11130727 |
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NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
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Plat |
plasminogen activator, tissue type |
involved_in |
IDA ISO IEA IBA |
(PMID:12694198), (PMID:17849409), (PMID:24196407) GO_REF:0000002 GO_REF:0000107 GO_REF:0000033 |
RGD InterPro Ensembl GO_Central |
PMID:12694198 PMID:17849409 PMID:24196407 PMID:8343497 |
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:11537479 |
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Plau |
plasminogen activator, urokinase |
involved_in |
ISO IBA IEA |
(PMID:25978044) GO_REF:0000033 GO_REF:0000107 |
RGD GO_Central Ensembl |
PMID:25978044 |
GO_REF:0000033 GO_REF:0000107 |
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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Tmprss9 |
transmembrane serine protease 9 |
acts_upstream_of_or_within |
ISO |
(PMID:16872279) |
RGD |
PMID:16872279 |
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NCBI chr 7:8,810,321...8,831,177
Ensembl chr 7:8,810,320...8,831,177
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Anxa2 |
annexin A2 |
involved_in |
ISO |
(PMID:9836589) |
RGD |
PMID:9836589 |
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NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
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Clec3b |
C-type lectin domain family 3, member B |
involved_in |
ISS ISO |
GO_REF:0000024 (PMID:12694198) |
UniProt RGD |
PMID:12694198 |
GO_REF:0000024 |
NCBI chr 8:122,810,120...122,815,837
Ensembl chr 8:122,810,149...122,815,835
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Eno1 |
enolase 1 |
involved_in |
ISO |
(PMID:12666133) |
RGD |
PMID:12666133 |
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NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 Ensembl chr 3:160,719,951...160,731,336
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F12 |
coagulation factor XII |
involved_in |
ISO IEA |
(PMID:89876) GO_REF:0000107 |
RGD Ensembl |
PMID:89876 |
GO_REF:0000107 |
NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
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Hpn |
hepsin |
involved_in |
ISS IEA ISO |
GO_REF:0000024 GO_REF:0000107 (PMID:16908524) |
UniProt Ensembl RGD |
PMID:16908524 |
GO_REF:0000024 GO_REF:0000107 |
NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
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Meltf |
melanotransferrin |
involved_in |
ISO |
(PMID:16713448) |
RGD |
PMID:16713448 |
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NCBI chr11:68,884,446...68,906,300
Ensembl chr11:68,884,446...68,906,300
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Plgrkt |
plasminogen receptor with a C-terminal lysine |
involved_in acts_upstream_of_or_within |
IBA ISO |
GO_REF:0000033 (PMID:19897580) |
GO_Central RGD |
PMID:19897580 |
GO_REF:0000033 |
NCBI chr 1:227,099,005...227,111,277
Ensembl chr 1:227,099,015...227,111,194
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Ruvbl1 |
RuvB-like AAA ATPase 1 |
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IDA |
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RGD |
PMID:11027681 |
RGD:67924 |
NCBI chr 4:120,932,486...120,967,400
Ensembl chr 4:120,932,417...121,029,384
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S100a10 |
S100 calcium binding protein A10 |
involved_in |
ISO IEA |
(PMID:9836589) GO_REF:0000107 |
RGD Ensembl |
PMID:9836589 |
GO_REF:0000107 |
NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661
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Cuzd1 |
CUB and zona pellucida-like domains 1 |
involved_in |
ISS IEA ISO |
GO_REF:0000024 GO_REF:0000107 (PMID:12401800) |
UniProt Ensembl RGD |
PMID:12401800 |
GO_REF:0000024 GO_REF:0000107 |
NCBI chr 1:186,089,422...186,130,536
Ensembl chr 1:186,089,423...186,102,546
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Term paths to the root
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