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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:graft-versus-host disease
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Accession:DOID:0081267 term browser browse the term
Definition:An immune system disease that is characterized by recognition by mature donor T cells, that contaminate the allogeneic bone marrow, of the recipient's tissue as foreign, causing a severe inflammatory disease characterized by rashes, diarrhea, and liver disease, and that has_material_basis_in an associated with variation in the interleukin-10 gene (IL10) on chromosome 1q32. (DO)
Synonyms:exact_synonym: GVHD;   GVHDS;   Graft vs Host Disease;   Graft-Versus-Host Diseases;   Graft-vs-Host Diseases;   Homologous Wasting Disease;   Runt Disease
 related_synonym: PLATELET-ENDOTHELIAL CELL ADHESION MOLECULE 1 POLYMORPHISM;   graft-versus-host disease, resistance to;   graft-versus-host disease, susceptibility to
 primary_id: MESH:D006086
 alt_id: DOID:9006073;   MIM:614395
 xref: ICD11:4B24;   ORDO:39812


show annotations for term's descendants           Sort by:
graft-versus-host disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABO ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase ISO RGD PMID:3289150 RGD:11100006 NCBI chr 1:272,912,239...272,935,316 JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing severity ISO protein:increased expression:serum RGD PMID:21258011 RGD:5686893 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646 		JBrowse link
G APOA4 apolipoprotein A4 ISO protein:increased expression:blood serum (human) RGD PMID:19379511 RGD:5685691 NCBI chr 9:44,201,587...44,204,072
Ensembl chr 9:44,201,508...44,204,206 		JBrowse link
G CCL8 chemokine (C-C motif) ligand 8 ISO RGD PMID:19571824 RGD:4892067 NCBI chr12:40,740,468...40,741,970
Ensembl chr12:40,740,023...40,742,022 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 severity ISO RGD PMID:17641205 RGD:5688177 NCBI chr13:29,227,218...29,233,862
Ensembl chr13:29,227,222...29,233,960 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO mRNA:increased expression:lung, liver, intestine (mouse) RGD PMID:19571824 RGD:4892067 NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,895 		JBrowse link
G CD40 CD40 molecule treatment ISO RGD PMID:18981161 RGD:7248735 NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528 		JBrowse link
G CD40LG CD40 ligand ISO RGD PMID:12970789 RGD:11352269 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,709 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 treatment ISO CTD Direct Evidence: therapeutic RGD
CTD		 PMID:7515723 PMID:14642129 RGD:11344912 NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,927...107,289,103 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 severity ISO RGD PMID:17264819 RGD:4892014 NCBI chr13:23,944,386...23,957,567
Ensembl chr13:23,944,369...23,957,486 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO mRNA, protein:increased expression:intestine, liver, lung RGD PMID:19218194 RGD:5135435 NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 ISO protein:increased expression:intestine, liver, lung RGD PMID:19218194 RGD:5135435 NCBI chr 8:71,713,790...71,725,669
Ensembl chr 8:71,713,803...71,725,674 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO mRNA, protein:increased expression:intestine, liver, lung RGD PMID:19218194 RGD:5135435 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:19218194 RGD:5135435 NCBI chr  X:57,592,032...57,595,706
Ensembl chr  X:57,592,038...57,595,692 		JBrowse link
G F3 coagulation factor III, tissue factor treatment ISO RGD PMID:20037809 RGD:11340209 NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,644...122,837,666 		JBrowse link
G FAS Fas cell surface death receptor ISO RGD PMID:9404931 RGD:11049160 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716 		JBrowse link
G FASLG Fas ligand ISO mRNA,protein:increased expression:liver: RGD PMID:9404931 PMID:10452880 RGD:11049160 RGD:14700681 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464 		JBrowse link
G FCGR3A Fc fragment of IgG receptor IIIa ISO DNA:polymorphism:cds:p. V158F(rs396991)(human) RGD PMID:20400988 RGD:11040884 NCBI chr 4:88,948,357...88,956,513 JBrowse link
G FOXP3 forkhead box P3 treatment ISO RGD PMID:22344929 RGD:38599140 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,785...43,322,968 		JBrowse link
G HGF hepatocyte growth factor treatment ISO RGD PMID:11390418 RGD:8548544 NCBI chr 9:98,437,771...98,513,573
Ensembl chr 9:98,438,143...98,513,564 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 ISO RGD PMID:9557158 RGD:7242787 NCBI chr 9:49,982,278...49,986,760
Ensembl chr 9:49,982,284...49,990,508 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:liver,bile duct: RGD PMID:10051478 RGD:11520783 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205 		JBrowse link
G IFNG interferon gamma susceptibility ISO associated with Cytomegalovirus Infections; DNA:repeats:intron:
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:16409297 PMID:19747638 PMID:22077062 RGD:10755684 RGD:10755687 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL10 interleukin 10 severity
no_association
treatment
disease_progression		 ISO DNA:repeat:promoter
DNA:polymorphisms
DNA:SNP: :rs1800872 (human)
ClinVar Annotator: match by term: Graft-versus-host disease, resistance to | ClinVar Annotator: match by term: Graft-versus-host disease, susceptibility to		 RGD
ClinVar
OMIM		 PMID:9808588 PMID:11121048 PMID:14657422 PMID:14657427 PMID:18550579 More... RGD:11041897 RGD:11046269 RGD:11049177 RGD:2316565 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL10RB interleukin 10 receptor subunit beta disease_progression ISO DNA:SNP: :rs28341676 (human) RGD PMID:19409109 RGD:11046269 NCBI chr13:196,853,606...196,884,237
Ensembl chr13:196,853,467...196,884,928 		JBrowse link
G IL17A interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD PMID:22077062 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153 		JBrowse link
G IL19 interleukin 19 ISO ClinVar Annotator: match by term: Graft-versus-host disease, resistance to | ClinVar Annotator: match by term: Graft-versus-host disease, susceptibility to ClinVar PMID:11121048 PMID:14657422 PMID:14657427 PMID:18550579 PMID:25741868 More... NCBI chr 9:67,469,519...67,479,597
Ensembl chr 9:67,469,524...67,479,813 		JBrowse link
G IL1A interleukin 1 alpha ISO DNA:SNP:promoter:-889T>C (rs1800587) (human) RGD PMID:23645090 RGD:11049180 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,121 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO RGD PMID:8049450 RGD:6909143
G IL2 interleukin 2 ISO RGD PMID:8704686 PMID:21734238 RGD:5147911 RGD:8662974 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609 		JBrowse link
G IL21R interleukin 21 receptor ISO RGD PMID:21596854 RGD:6892927 NCBI chr 3:19,447,488...19,489,201
Ensembl chr 3:19,443,359...19,489,152 		JBrowse link
G ITGA2 integrin subunit alpha 2 treatment ISO RGD PMID:11489992 RGD:8693305 NCBI chr16:32,336,240...32,440,311
Ensembl chr16:32,336,292...32,437,103 		JBrowse link
G JAK3 Janus kinase 3 treatment ISO RGD PMID:11781254 PMID:12010825 RGD:11531124 RGD:1600262 NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495 		JBrowse link
G LST1 leukocyte specific transcript 1 ISO DNA:repeat:intron:IVS3dupGA (human) RGD PMID:9808588 RGD:2316565 NCBI chr 7:23,705,491...23,712,987 JBrowse link
G MKI67 marker of proliferation Ki-67 ISO RGD PMID:21440078 RGD:6483534 NCBI chr14:137,266,622...137,296,312 JBrowse link
G MTHFR methylenetetrahydrofolate reductase treatment ISO CTD Direct Evidence: marker/mechanism
DNA:transition:cds:g.677C>T (human)		 CTD
RGD		 PMID:16518429 PMID:19005482 RGD:6893635 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 severity ISO DNA:snps, insertion:exons:p.R675W, p.G1881R, c.2936_2937insC (human) RGD PMID:15090455 RGD:8158050 NCBI chr 6:34,132,127...34,167,446
Ensembl chr 6:34,130,938...34,177,534 		JBrowse link
G PDGFB platelet derived growth factor subunit B ISO RGD PMID:21211989 RGD:6482796 Ensembl chr 5:8,986,462...9,007,435 JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO ClinVar Annotator: match by term: PLATELET-ENDOTHELIAL CELL ADHESION MOLECULE 1 POLYMORPHISM ClinVar PMID:8532023 NCBI chr12:14,667,643...14,723,296
Ensembl chr12:14,649,044...14,723,293 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:21402770 RGD:6482681 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 susceptibility ISO DNA:snp:promoter:g.-1123G>C (rs2488457) (human) RGD PMID:23025987 RGD:11534005 NCBI chr 4:106,692,102...106,758,101
Ensembl chr 4:106,686,604...106,758,099 		JBrowse link
G SELL selectin L ISO RGD PMID:21635226 RGD:5685693 NCBI chr 4:81,306,363...81,325,296
Ensembl chr 4:81,306,353...81,326,444 		JBrowse link
G SERPINE1 serpin family E member 1 Treatment ISO RGD PMID:26414805 RGD:11343779 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547 		JBrowse link
G TFPI tissue factor pathway inhibitor treatment ISO RGD PMID:20037809 RGD:11340209 NCBI chr15:92,345,083...92,409,962
Ensembl chr15:92,345,075...92,409,905 		JBrowse link
G TNFRSF8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15322151 NCBI chr 6:72,103,309...72,174,882 JBrowse link
G TNFSF8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15322151 NCBI chr 1:255,436,206...255,459,020
Ensembl chr 1:255,432,969...255,459,073 		JBrowse link
G TP53 tumor protein p53 ISO protein:increased expression:epithelium RGD PMID:16393253 RGD:8547841 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO protein:decreased expression:serum: RGD PMID:25759146 RGD:11079181 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15390
    disease of anatomical entity 15084
      immune system disease 4544
        graft-versus-host disease 48
          Bronchiolitis Obliterans Syndrome 0
Path 2
Term Annotations click to browse term
  disease 15390
    disease of anatomical entity 15084
      Immune & Inflammatory Diseases 5142
        immune system disease 4544
          graft-versus-host disease 48
            Bronchiolitis Obliterans Syndrome 0
paths to the root