NOD2 (nucleotide binding oligomerization domain containing 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: NOD2 (nucleotide binding oligomerization domain containing 2) Sus scrofa
Analyze
Symbol: NOD2
Name: nucleotide binding oligomerization domain containing 2
RGD ID: 14127255
Description: ENCODES a protein that exhibits enzyme binding (ortholog); muramyl dipeptide binding (ortholog); INVOLVED IN activation of immune response (ortholog); cellular response to organic cyclic compound (ortholog); cellular response to peptidoglycan (ortholog); PARTICIPATES IN NOD-like receptor signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH acne (ortholog); Acute Lung Injury (ortholog); allergic rhinitis (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog); vesicle (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,130,938 - 34,177,534 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,132,127 - 34,167,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
Acute Lung Injury  (ISO)
allergic rhinitis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Blau syndrome  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
dermatitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
familial Mediterranean fever  (ISO)
gastritis  (ISO)
gastrointestinal carcinoma  (ISO)
genetic disease  (ISO)
Graft vs Host Disease  (ISO)
Granuloma  (ISO)
hidradenitis suppurativa  (ISO)
inflammatory bowel disease  (ISO)
inflammatory bowel disease 1  (ISO)
intestinal disease  (ISO)
larynx cancer  (ISO)
Legionnaires' disease  (ISO)
leprosy  (ISO)
lung cancer  (ISO)
Lyme disease  (ISO)
meningococcal meningitis  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (ISO)
Ocular Toxoplasmosis  (ISO)
ovarian cancer  (ISO)
pancreatitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
PFAPA Syndrome  (ISO)
Pneumococcal Meningitis  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pyoderma gangrenosum  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
Reperfusion Injury  (ISO)
rhinitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Splenomegaly  (ISO)
Staphylococcal Pneumonia  (ISO)
systemic lupus erythematosus  (ISO)
transient cerebral ischemia  (ISO)
ulcerative colitis  (ISO)
uveitis  (ISO)
YAO SYNDROME  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of immune response  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA)
cellular response to muramyl dipeptide  (IEA)
cellular response to organic cyclic compound  (ISO)
cellular response to peptidoglycan  (IEA,ISO)
defense response to bacterium  (ISO)
defense response to Gram-positive bacterium  (IEA,ISO)
detection of bacterium  (IEA)
detection of muramyl dipeptide  (IEA,ISO)
innate immune response  (ISO)
innate immune response in mucosa  (IEA,ISO)
intracellular signal transduction  (ISO)
maintenance of gastrointestinal epithelium  (IEA)
negative regulation of inflammatory response to antigenic stimulus  (IEA,ISO)
negative regulation of interferon-gamma production  (IEA,ISO)
negative regulation of interleukin-12 production  (IEA,ISO)
negative regulation of interleukin-18 production  (IEA,ISO)
negative regulation of interleukin-2 production  (IEA,ISO)
negative regulation of macrophage apoptotic process  (IEA)
negative regulation of NF-kappaB transcription factor activity  (IEA,ISO)
negative regulation of T cell mediated immunity  (IEA,ISO)
negative regulation of toll-like receptor 2 signaling pathway  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
pattern recognition receptor signaling pathway  (ISO)
positive regulation of antibacterial peptide biosynthetic process  (ISO)
positive regulation of B cell activation  (IEA)
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production involved in immune response  (IEA)
positive regulation of cytokine production involved in inflammatory response  (IEA)
positive regulation of dendritic cell antigen processing and presentation  (IEA)
positive regulation of dendritic cell cytokine production  (ISO)
positive regulation of epithelial cell proliferation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of humoral immune response mediated by circulating immunoglobulin  (IEA,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISO)
positive regulation of innate immune response  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-17 production  (IEA)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of MAP kinase activity  (IEA)
positive regulation of MAPK cascade  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (IEA)
positive regulation of NF-kappaB transcription factor activity  (IEA,ISO)
positive regulation of NIK/NF-kappaB signaling  (IEA,ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (IEA)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of oxidoreductase activity  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phagocytosis  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (IEA)
positive regulation of prostaglandin-E synthase activity  (IEA)
positive regulation of prostaglandin-endoperoxide synthase activity  (IEA)
positive regulation of protein K63-linked ubiquitination  (IEA)
positive regulation of protein ubiquitination  (ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type 2 immune response  (IEA)
positive regulation of xenophagy  (IEA,ISO)
regulation of apoptotic process  (IEA)
regulation of inflammatory response  (ISO)
regulation of neutrophil chemotaxis  (IEA,ISO)
response to exogenous dsRNA  (IEA,ISO)
response to lipopolysaccharide  (ISO)
response to muramyl dipeptide  (ISO)
response to nutrient  (ISO)
response to peptidoglycan  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17559936   PMID:19099299   PMID:19822368   PMID:31030118  


Genomics

Comparative Map Data
NOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,130,938 - 34,177,534 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,132,127 - 34,167,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1650,693,588 - 50,734,041 (+)EnsemblGRCh38hg38GRCh38
GRCh381650,693,587 - 50,733,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371650,727,517 - 50,766,986 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361649,288,551 - 49,324,488 (+)NCBINCBI36hg18NCBI36
Build 341649,288,550 - 49,324,488NCBI
Celera1635,246,377 - 35,282,313 (+)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1636,618,016 - 36,653,950 (+)NCBIHuRef
CHM1_11652,138,579 - 52,174,513 (+)NCBICHM1_1
Nod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39889,373,943 - 89,415,103 (+)NCBIGRCm39mm39
GRCm39 Ensembl889,373,943 - 89,415,102 (+)Ensembl
GRCm38888,647,315 - 88,688,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37891,171,246 - 91,212,373 (+)NCBIGRCm37mm9NCBIm37
MGSCv36891,537,452 - 91,578,579 (+)NCBImm8
Celera892,927,621 - 92,968,882 (+)NCBICelera
Cytogenetic Map8C3NCBI
Nod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21918,379,720 - 18,422,817 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1918,382,439 - 18,417,177 (-)Ensembl
Rnor_6.01919,342,061 - 19,389,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,332,594 - 19,377,492 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,375,065 - 30,409,527 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41919,662,337 - 19,697,341 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11919,670,606 - 19,715,845 (-)NCBI
Celera1918,269,940 - 18,304,004 (-)NCBICelera
Cytogenetic Map19p11NCBI
Nod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,746,004 - 8,782,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,746,213 - 8,780,119 (+)NCBIChiLan1.0ChiLan1.0
NOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11649,834,385 - 49,873,783 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,837,891 - 49,873,773 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01630,955,976 - 30,995,451 (+)NCBIMhudiblu_PPA_v0panPan3
NOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,636,850 - 64,667,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,209,788 - 61,240,085 (-)NCBI
ROS_Cfam_1.0265,182,339 - 65,218,538 (-)NCBI
UMICH_Zoey_3.1262,006,039 - 62,036,328 (-)NCBI
UNSW_CanFamBas_1.0263,025,931 - 63,056,292 (-)NCBI
UU_Cfam_GSD_1.0263,913,478 - 63,943,824 (-)NCBI
Nod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934955,844,066 - 55,881,006 (-)NCBI
SpeTri2.0NW_0049364753,708,069 - 3,742,845 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1536,492,158 - 36,531,766 (+)NCBI
ChlSab1.1 Ensembl536,496,414 - 36,530,499 (+)Ensembl
Vero_WHO_p1.0NW_02366604739,970,704 - 40,009,792 (-)NCBI
Nod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247575,956,873 - 6,000,052 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 6 2 1 5 15 2 3
Below cutoff 4 2 2 2 8 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000041200   ⟹   ENSSSCP00000057048
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl634,132,109 - 34,177,534 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000061032   ⟹   ENSSSCP00000053651
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl634,132,109 - 34,177,534 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000078479   ⟹   ENSSSCP00000070121
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl634,132,109 - 34,177,534 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000081424   ⟹   ENSSSCP00000069042
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl634,130,938 - 34,173,127 (-)Ensembl
RefSeq Acc Id: NM_001105295   ⟹   NP_001098765
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1634,132,127 - 34,167,446 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001098765 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABY61044 (Get FASTA)   NCBI Sequence Viewer  
  BAF76325 (Get FASTA)   NCBI Sequence Viewer  
  BAH24204 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001098765   ⟸   NM_001105295
- UniProtKB: A7VJM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000070121   ⟸   ENSSSCT00000078479
RefSeq Acc Id: ENSSSCP00000057048   ⟸   ENSSSCT00000041200
RefSeq Acc Id: ENSSSCP00000053651   ⟸   ENSSSCT00000061032
RefSeq Acc Id: ENSSSCP00000069042   ⟸   ENSSSCT00000081424
Protein Domains
CARD   NACHT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000038073 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070013849 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000053651 UniProtKB/TrEMBL
  ENSSSCP00000057048 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000069042 UniProtKB/TrEMBL
  ENSSSCP00000070121 UniProtKB/TrEMBL
  ENSSSCP00070022624 UniProtKB/TrEMBL
  ENSSSCP00070022631 UniProtKB/TrEMBL
  ENSSSCP00070022648 UniProtKB/TrEMBL
  ENSSSCP00070022666 UniProtKB/TrEMBL
  ENSSSCP00070022675 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000041200 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000061032 UniProtKB/TrEMBL
  ENSSSCT00000078479 UniProtKB/TrEMBL
  ENSSSCT00000081424 UniProtKB/TrEMBL
  ENSSSCT00070027200 UniProtKB/TrEMBL
  ENSSSCT00070027209 UniProtKB/TrEMBL
  ENSSSCT00070027233 UniProtKB/TrEMBL
  ENSSSCT00070027260 UniProtKB/TrEMBL
  ENSSSCT00070027271 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  NLRC_HD2 UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report ssc:100125838 UniProtKB/TrEMBL
NCBI Gene NOD2 ENTREZGENE
Pfam CARD UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A287BAS5_PIG UniProtKB/TrEMBL
  A0A287BKC9_PIG UniProtKB/TrEMBL
  A0A4X1TYT5_PIG UniProtKB/TrEMBL
  A0A4X1TYY6_PIG UniProtKB/TrEMBL
  A0A4X1U1J1_PIG UniProtKB/TrEMBL
  A0A4X1U1M6_PIG UniProtKB/TrEMBL
  A0A4X1U4E4_PIG UniProtKB/TrEMBL
  A0A5G2QYZ6_PIG UniProtKB/TrEMBL
  A0A5G2RE17_PIG UniProtKB/TrEMBL
  A7VJM2 ENTREZGENE, UniProtKB/TrEMBL
  B0FSM8_PIG UniProtKB/TrEMBL
  B9WZD7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:98520 ENTREZGENE