RGD Reference Report - Investigation of functional IL-10 gene polymorphism and IL-10 levels in acute graft-versus-host disease. - Rat Genome Database

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Investigation of functional IL-10 gene polymorphism and IL-10 levels in acute graft-versus-host disease.

Authors: Resende, RG  Correia-Silva Jde, F  Arao, TC  Silva, TA  Abreu, MH  Bittencourt, H  Gomez, RS 
Citation: Resende RG, etal., J Clin Immunol. 2010 May;30(3):465-73. doi: 10.1007/s10875-010-9377-6. Epub 2010 Mar 2.
RGD ID: 11049177
Pubmed: PMID:20195716   (View Abstract at PubMed)
DOI: DOI:10.1007/s10875-010-9377-6   (Journal Full-text)

BACKGROUND: Graft-versus-host disease (GVHD) represents a major complication in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. Although studies have been conducted concerning the investigation of cytokine polymorphisms in the development of acute GVHD (aGVHD), the contribution of recipients and donors as regards cytokine levels has not yet been thoroughly assessed. OBJECTIVE: The aim of this study was to investigate the impact of IL-10 polymorphisms on cytokine levels in blood and saliva, in addition to the occurrence and severity of aGVHD. METHODS: Fifty-eight consecutive allo-HSCT recipients and their donors were included in this prospective study. Saliva and/or blood samples were obtained from recipients and donors to determine IL10 polymorphisms. The IL-10 levels in the blood and saliva were also assessed. The samples were collected from seven days before transplant (day -7) to 100 days after allo-HSCT (day +100), once a week or until the death of recipient. RESULTS: No association was found between recipient and donor IL10 polymorphism and IL-10 levels in the saliva with aGVHD. In contrast, IL-10 levels in the blood were associated with the occurrence of aGVHD. The high producer phenotype in the recipient was also associated with high levels of IL-10 in the blood and saliva. CONCLUSION: Although IL10 polymorphisms were not associated with the occurrence and severity of aGVHD, the genetic background of the recipient did in fact influence the production of the cytokine. Furthermore, as IL-10 levels in the blood were associated with the disease development, this parameter may well be a useful predictor of aGVHD development.




  
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Original Reference(s)
IL10Humangraft-versus-host disease no_associationIAGP DNA:polymorphismsRGD 
Il10Ratgraft-versus-host disease no_associationISOIL10 (Homo sapiens)DNA:polymorphismsRGD 
Il10Mousegraft-versus-host disease no_associationISOIL10 (Homo sapiens)DNA:polymorphismsRGD 


Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)