RGD Reference Report - Hepatocyte growth factor ameliorates acute graft-versus-host disease and promotes hematopoietic function. - Rat Genome Database

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Hepatocyte growth factor ameliorates acute graft-versus-host disease and promotes hematopoietic function.

Authors: Kuroiwa, T  Kakishita, E  Hamano, T  Kataoka, Y  Seto, Y  Iwata, N  Kaneda, Y  Matsumoto, K  Nakamura, T  Ueki, T  Fujimoto, J  Iwasaki, T 
Citation: Kuroiwa T, etal., J Clin Invest. 2001 Jun;107(11):1365-73.
RGD ID: 8548544
Pubmed: PMID:11390418   (View Abstract at PubMed)
PMCID: PMC209319   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI11808   (Journal Full-text)

Acute graft-versus-host disease (GVHD) is a major complication of bone marrow transplantation (BMT) and is characterized by hematopoietic dysfunction, immunosuppression, and tissue injury in the skin, liver, and intestinal mucosa. Hepatocyte growth factor (HGF), originally identified and cloned as a potent mitogen for hepatocytes, induces mitogenic and antiapoptotic activity in various epithelial cells and promotes hematopoiesis. Working in a murine model of acute GVHD, we performed repeated transfection of the human HGF cDNA into skeletal muscle and showed that this treatment inhibited apoptosis of intestinal epithelial cells and donor T-cell infiltration into the liver, thereby ameliorating the enteropathy and liver injury caused by acute GVHD. HGF also markedly suppressed IFN-gamma and TNF-alpha expression in the intestine and liver and decreased the serum IL-12. Furthermore, extramedullary hematopoiesis by donor cells was increased, and the survival rate was improved. These results suggest that HGF may be useful for controlling acute GVHD after allogeneic BMT.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
graft-versus-host disease treatmentIDA 8548544 RGD 
graft-versus-host disease treatmentISOHGF (Homo sapiens)8548544; 8548544 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hgf  (hepatocyte growth factor)

Genes (Mus musculus)
Hgf  (hepatocyte growth factor)

Genes (Homo sapiens)
HGF  (hepatocyte growth factor)


Additional Information