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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:quetiapine
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Accession:CHEBI:8707 term browser browse the term
Definition:A dibenzothiazepine that has formula C21H25N3O2S.
Synonyms:exact_synonym: 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol
 related_synonym: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol;   Formula=C21H25N3O2S;   InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2;   InChIKey=URKOMYMAXPYINW-UHFFFAOYSA-N;   SMILES=OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12;   quetiapina;   quetiapinum
 xref: CAS:111974-69-7;   DrugBank:DB01224;   Drug_Central:2337;   KEGG:C07397;   KEGG:D08456;   LINCS:LSM-3543;   Patent:EP240228;   Patent:US4879288;   Wikipedia:Quetiapine


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quetiapine fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO Quetiapine Fumarate results in decreased activity of ABCB1 protein CTD PMID:16810505 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Quetiapine Fumarate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Quetiapine Fumarate inhibits the reaction [APP protein modified form affects the activity of CAT protein]; Quetiapine Fumarate inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:15948179 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Quetiapine Fumarate results in increased expression of BAX protein CTD PMID:16462815 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Quetiapine Fumarate results in increased expression of BDNF protein CTD PMID:17442489 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cat catalase multiple interactions EXP Quetiapine Fumarate inhibits the reaction [APP protein modified form affects the activity of CAT protein] CTD PMID:15948179 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression ISO Quetiapine Fumarate results in decreased expression of CNR1 protein CTD PMID:31220554 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression ISO Quetiapine Fumarate results in increased expression of CNR2 protein CTD PMID:31220554 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Quetiapine Fumarate promotes the reaction [Dopamine binds to DRD2 protein] CTD PMID:15716360 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO Quetiapine Fumarate inhibits the reaction [Ketanserin binds to HTR2A protein] CTD PMID:16314884 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Quetiapine Fumarate inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Quetiapine Fumarate results in decreased activity of KCNH2 protein
CTD PMID:21158687, PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases metabolic processing ISO Quetiapine Fumarate results in decreased metabolism of MAP1LC3B protein CTD PMID:31220554 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mbp myelin basic protein multiple interactions ISO Quetiapine Fumarate inhibits the reaction [Cuprizone results in decreased activity of MBP protein] CTD PMID:18938062 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Quetiapine Fumarate affects the localization of MLKL protein]; 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Quetiapine Fumarate results in increased expression of and results in increased phosphorylation of MLKL protein]; AM 1241 inhibits the reaction [Quetiapine Fumarate affects the localization of MLKL protein]; AM 1241 inhibits the reaction [Quetiapine Fumarate results in increased expression of and results in increased phosphorylation of MLKL protein]; AM 281 inhibits the reaction [Quetiapine Fumarate affects the localization of MLKL protein]; AM 281 inhibits the reaction [Quetiapine Fumarate results in increased phosphorylation of MLKL protein]; Quetiapine Fumarate results in increased expression of and affects the localization of MLKL protein; Quetiapine Fumarate results in increased expression of and results in increased phosphorylation of MLKL protein; Rimonabant inhibits the reaction [Quetiapine Fumarate affects the localization of MLKL protein]; Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of and results in increased phosphorylation of MLKL protein] CTD PMID:31220554 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Quetiapine Fumarate results in increased expression of NDUFV2 mRNA CTD PMID:19441803 NCBI chr 9:113,875,718...113,900,169
Ensembl chr 9:113,875,703...113,900,190
JBrowse link
G Ngfr nerve growth factor receptor decreases expression EXP Quetiapine Fumarate results in decreased expression of NGFR mRNA CTD PMID:12111809, PMID:16513140 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Prl prolactin decreases expression
increases secretion
ISO Quetiapine Fumarate results in decreased expression of PRL protein
Quetiapine Fumarate results in increased secretion of PRL protein
CTD PMID:16379509, PMID:18063941 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions
increases expression
ISO AM 281 inhibits the reaction [Quetiapine Fumarate results in increased expression of RIPK1 protein]; Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of RIPK1 protein] CTD PMID:31220554 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions
increases expression
ISO Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of RIPK3 protein] CTD PMID:31220554 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Quetiapine Fumarate inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:30465787 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
ISO
EXP
Quetiapine Fumarate inhibits the reaction [Cuprizone results in decreased activity of SOD1 protein]
Quetiapine Fumarate results in increased expression of SOD1 mRNA
Quetiapine Fumarate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]
CTD PMID:12111809, PMID:12752374, PMID:18938062 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        pharmacological role 18821
          antagonist 16219
            histamine antagonist 4606
              quetiapine 21
                quetiapine fumarate 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            inorganic hydride 17433
                              pnictogen hydride 17405
                                nitrogen hydride 17247
                                  azane 16964
                                    ammonia 16963
                                      organic amino compound 16962
                                        tertiary amino compound 8638
                                          N-alkylpiperazine 3080
                                            quetiapine 21
                                              quetiapine fumarate 21
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