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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:betamethasone
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Accession:CHEBI:3077 term browser browse the term
Definition:A glucocorticoid that has formula C22H29FO5.
Synonyms:exact_synonym: 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
 related_synonym: 16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione;   9-Fluoro-16beta-methylprednisolone;   9alpha-Fluoro-16beta-methylprednisolone;   Betadexamethasone;   Formula=C22H29FO5;   InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1;   InChIKey=UREBDLICKHMUKA-DVTGEIKXSA-N;   Rinderon;   SMILES=[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C;   beta-Methasone alcohol;   betametasona;   betamethasonum
 xref: Beilstein:3176546;   CAS:378-44-9;   DrugBank:DB00443;   Drug_Central:348;   KEGG:D00244
 xref_mesh: MESH:D001623
 xref: Patent:US3053865;   Patent:US3104246;   VSDB:1854;   Wikipedia:Betamethasone



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betamethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp4 aquaporin 4 increases expression EXP Betamethasone results in increased expression of AQP4 mRNA CTD PMID:9409467 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Ar androgen receptor multiple interactions ISO Betamethasone binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Betamethasone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Betamethasone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Betamethasone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Egr1 early growth response 1 affects expression ISO Betamethasone affects the expression of EGR1 mRNA CTD PMID:23461915 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Betamethasone results in decreased expression of FSHB protein CTD PMID:27132128 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Fxn frataxin increases expression ISO Betamethasone results in increased expression of FXN mRNA CTD PMID:23418481 NCBI chr 1:221,874,007...221,897,841
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO Betamethasone results in increased expression of and results in increased activity of HPGD protein CTD PMID:15680906 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
increases metabolic processing
EXP
ISO
Betamethasone inhibits the reaction [HSD11B2 protein affects the metabolism of Corticosterone]
HSD11B2 protein results in increased metabolism of Betamethasone
CTD PMID:16549198 PMID:19490994 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO Betamethasone results in increased expression of HSD17B4 mRNA CTD PMID:29901742 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Betamethasone results in increased expression of LHB protein CTD PMID:27132128 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity
affects binding
ISO NR3C1 protein alternative form inhibits the reaction [Betamethasone results in increased activity of NR3C1 protein alternative form]
Betamethasone binds to NR3C1 protein
CTD PMID:15362971 PMID:15755863 PMID:16507850 PMID:21543282 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Betamethasone results in increased activity of NR3C2 protein CTD PMID:15362971 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Betamethasone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
betamethasone dipropionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO betamethasone-17,21-dipropionate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
betamethasone valerate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule decreases expression ISO Betamethasone Valerate results in decreased expression of CD40 protein CTD PMID:15940147 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd83 CD83 molecule decreases expression ISO Betamethasone Valerate results in decreased expression of CD83 protein CTD PMID:15940147 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cd86 CD86 molecule decreases expression ISO Betamethasone Valerate results in decreased expression of CD86 protein CTD PMID:15940147 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO Betamethasone Valerate results in decreased expression of CSF2 protein CTD PMID:11407316 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ifng interferon gamma decreases expression ISO Betamethasone Valerate results in decreased expression of IFNG protein CTD PMID:11407316 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il2 interleukin 2 decreases expression ISO Betamethasone Valerate results in decreased expression of IL2 protein CTD PMID:11407316 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il3 interleukin 3 decreases expression ISO Betamethasone Valerate results in decreased expression of IL3 protein CTD PMID:11407316 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il4 interleukin 4 decreases expression ISO Betamethasone Valerate results in decreased expression of IL4 protein CTD PMID:11407316 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 decreases expression ISO Betamethasone Valerate results in decreased expression of IL5 protein CTD PMID:11407316 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        anti-asthmatic agent 9241
          betamethasone 25
            betamethasone acetate 0
            betamethasone acibutate 0
            betamethasone dipropionate + 1
            betamethasone phosphate 0
            betamethasone valerate 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      ketone 16926
                                        oxyketone 8664
                                          alpha-oxyketone 8664
                                            alpha-hydroxy ketone 8664
                                              primary alpha-hydroxy ketone 7547
                                                betamethasone 25
                                                  betamethasone acetate 0
                                                  betamethasone acibutate 0
                                                  betamethasone dipropionate + 1
                                                  betamethasone phosphate 0
                                                  betamethasone valerate 9
paths to the root