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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:betamethasone
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Accession:CHEBI:3077 term browser browse the term
Definition:A glucocorticoid that has formula C22H29FO5.
Synonyms:exact_synonym: 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
 related_synonym: 16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione;   9-Fluoro-16beta-methylprednisolone;   9alpha-Fluoro-16beta-methylprednisolone;   Betadexamethasone;   Formula=C22H29FO5;   InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1;   InChIKey=UREBDLICKHMUKA-DVTGEIKXSA-N;   Rinderon;   SMILES=[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C;   beta-Methasone alcohol;   betametasona;   betamethasonum
 xref: Beilstein:3176546;   CAS:378-44-9;   DrugBank:DB00443;   Drug_Central:348;   KEGG:D00244
 xref_mesh: MESH:D001623
 xref: Patent:US3053865;   Patent:US3104246;   VSDB:1854;   Wikipedia:Betamethasone


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betamethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp4 aquaporin 4 increases expression EXP Betamethasone results in increased expression of AQP4 mRNA CTD PMID:9409467 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Ar androgen receptor multiple interactions ISO Betamethasone binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Betamethasone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Betamethasone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Betamethasone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Egr1 early growth response 1 affects expression ISO Betamethasone affects the expression of EGR1 mRNA CTD PMID:23461915 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Betamethasone results in decreased expression of FSHB protein CTD PMID:27132128 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fxn frataxin increases expression ISO Betamethasone results in increased expression of FXN mRNA CTD PMID:23418481 NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO Betamethasone results in increased expression of and results in increased activity of HPGD protein CTD PMID:15680906 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
increases metabolic processing
EXP
ISO
Betamethasone inhibits the reaction [HSD11B2 protein affects the metabolism of Corticosterone]
HSD11B2 protein results in increased metabolism of Betamethasone
CTD PMID:16549198, PMID:19490994 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Betamethasone results in increased expression of LHB protein CTD PMID:27132128 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity
affects binding
ISO NR3C1 protein alternative form inhibits the reaction [Betamethasone results in increased activity of NR3C1 protein alternative form]
Betamethasone binds to NR3C1 protein
CTD PMID:15362971, PMID:15755863, PMID:16507850, PMID:21543282 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Betamethasone results in increased activity of NR3C2 protein CTD PMID:15362971 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Betamethasone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
betamethasone dipropionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO betamethasone-17,21-dipropionate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
betamethasone valerate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule decreases expression ISO Betamethasone Valerate results in decreased expression of CD40 protein CTD PMID:15940147 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd83 CD83 molecule decreases expression ISO Betamethasone Valerate results in decreased expression of CD83 protein CTD PMID:15940147 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cd86 CD86 molecule decreases expression ISO Betamethasone Valerate results in decreased expression of CD86 protein CTD PMID:15940147 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO Betamethasone Valerate results in decreased expression of CSF2 protein CTD PMID:11407316 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ifng interferon gamma decreases expression ISO Betamethasone Valerate results in decreased expression of IFNG protein CTD PMID:11407316 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il2 interleukin 2 decreases expression ISO Betamethasone Valerate results in decreased expression of IL2 protein CTD PMID:11407316 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il3 interleukin 3 decreases expression ISO Betamethasone Valerate results in decreased expression of IL3 protein CTD PMID:11407316 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il4 interleukin 4 decreases expression ISO Betamethasone Valerate results in decreased expression of IL4 protein CTD PMID:11407316 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 decreases expression ISO Betamethasone Valerate results in decreased expression of IL5 protein CTD PMID:11407316 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        anti-asthmatic agent 9174
          betamethasone 24
            betamethasone acetate 0
            betamethasone acibutate 0
            betamethasone dipropionate + 1
            betamethasone phosphate 0
            betamethasone valerate 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        oxyketone 8631
                                          alpha-oxyketone 8631
                                            alpha-hydroxy ketone 8631
                                              primary alpha-hydroxy ketone 7516
                                                betamethasone 24
                                                  betamethasone acetate 0
                                                  betamethasone acibutate 0
                                                  betamethasone dipropionate + 1
                                                  betamethasone phosphate 0
                                                  betamethasone valerate 9
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