betamethasone valerate - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	betamethasone valerate	go back to main search page
Accession:	CHEBI:31277	browse the term
Definition:	A steroid ester that is betamethasone in which the hydroxy group at the 17alpha position has been converted to the corresponding pentanoate ester.
Synonyms:	exact_synonym:	9-fluoro-11beta,21-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl pentanoate
	related_synonym:	9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione-17-valerate; 9-fluoro-11beta,21-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl valerate; Betamethasone 17-valerate; Formula=C27H37FO6; InChI=1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1; InChIKey=SNHRLVCMMWUAJD-SUYDQAKGSA-N; SMILES=[H][C@@]12C[C@H](C)[C@](OC(=O)CCCC)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
	xref:	Beilstein:4240001; CAS:2152-44-5; DrugBank:DB00443; Drug_Central:354; KEGG:D01357
	xref_mesh:	MESH:D001624
	xref:	Patent:NL6406615

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Rat (9) Mouse (9) Human (9) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (9)

betamethasone valerate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD40 molecule

decreases expression

Betamethasone Valerate results in decreased expression of CD40 protein

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD83 molecule

decreases expression

Betamethasone Valerate results in decreased expression of CD83 protein

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

G

CD86 molecule

decreases expression

Betamethasone Valerate results in decreased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

colony stimulating factor 2

decreases expression

Betamethasone Valerate results in decreased expression of CSF2 protein

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

interferon gamma

decreases expression

Betamethasone Valerate results in decreased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 2

decreases expression

Betamethasone Valerate results in decreased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 3

decreases expression

Betamethasone Valerate results in decreased expression of IL3 protein

NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066

G

interleukin 4

decreases expression

Betamethasone Valerate results in decreased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

decreases expression

Betamethasone Valerate results in decreased expression of IL5 protein

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20059
role	20009
application	19747
anti-asthmatic agent	9254
betamethasone	25
betamethasone valerate	9
Path 2
Term	Annotations
CHEBI ontology	20059
subatomic particle	20056
composite particle	20056
hadron	20056
baryon	20056
nucleon	20056
atomic nucleus	20056
atom	20056
main group element atom	19956
p-block element atom	19956
carbon group element atom	19882
carbon atom	19873
organic molecular entity	19873
organic group	18943
organic divalent group	18928
organodiyl group	18928
carbonyl group	18877
carbonyl compound	18877
ketone	17090
oxyketone	8732
alpha-oxyketone	8732
alpha-hydroxy ketone	8732
primary alpha-hydroxy ketone	7594
betamethasone	25
betamethasone valerate	9

paths to the root