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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:betamethasone dipropionate
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Accession:CHEBI:31276 term browser browse the term
Definition:A steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasis in adult patients.
Synonyms:exact_synonym: 9-fluoro-11beta-hydroxy-16beta-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate
 related_synonym: 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione-17,21-dipropionate;   Betamethasone 17,21-dipropionate;   Formula=C28H37FO7;   InChI=1S/C28H37FO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1;   InChIKey=CIWBQSYVNNPZIQ-XYWKZLDCSA-N;   SMILES=[H][C@@]12C[C@H](C)[C@](OC(=O)CC)(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
 xref: Beilstein:3638108;   CAS:5593-20-4;   DrugBank:DB00443;   Drug_Central:353;   KEGG:D01637
 xref_mesh: MESH:C011175
 xref: PMID:23621170;   PMID:24533503;   PMID:24593129;   PMID:24684739;   PMID:24684740;   PMID:24980277;   PMID:25279474;   PMID:25307472;   PMID:25355140;   PMID:25410121;   PMID:25412565;   PMID:25556056;   PMID:25566573;   PMID:25607705;   PMID:26094549;   PMID:26444907;   PMID:26659941;   Reaxys:3638108;   Wikipedia:Betamethasone_Dipropionate


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betamethasone dipropionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO betamethasone-17,21-dipropionate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19783
    role 19728
      application 19419
        anti-asthmatic agent 9203
          betamethasone 25
            betamethasone dipropionate 1
              Enstilar 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19783
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18606
                              organic divalent group 18597
                                organodiyl group 18597
                                  carbonyl group 18510
                                    carbonyl compound 18510
                                      ketone 16828
                                        oxyketone 8663
                                          alpha-oxyketone 8663
                                            alpha-hydroxy ketone 8663
                                              primary alpha-hydroxy ketone 7541
                                                betamethasone 25
                                                  betamethasone dipropionate 1
                                                    Enstilar 0
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