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solasodine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:solasodine
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Accession:CHEBI:9190 term browser browse the term
Definition:An oxaspiro compound and steroid alkaloid sapogenin with formula C27H43NO2 found in the Solanum (nightshade) family. It is used as a precursor in the synthesis of complex steroidal compounds such as contraceptive pills.
Synonyms:exact_synonym: (25R)-22alpha-spirosol-5-en-3beta-ol
 related_synonym: (2S,2'R,4aR,4bS,5'R,6aS,6bR,7S,9aS,10aS,10bS)-4a,5',6a,7-tetramethyl-1,2,3,4,4a,4b,5,6,6a,6b,7,9a,10,10a,10b,11-hexadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-8,2'-piperidin]-2-ol;   (3beta,22alpha,25R)-spirosol-5-en-3-ol;   Formula=C27H43NO2;   InChI=1S/C27H43NO2/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28-29H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1;   InChIKey=KWVISVAMQJWJSZ-VKROHFNGSA-N;   SMILES=[C@]12([C@]3([C@@]([C@@]4(C(C[C@@H](O)CC4)=CC3)C)(CC[C@]2(C)[C@]5([C@@H]([C@@]6(O[C@]5(C1)[H])NC[C@H](C)CC6)C)[H])[H])[H])[H];   purapuridine;   solasod-5-en-3beta-ol;   spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-piperidine]
 alt_id: CHEBI:95154
 xref: AGR:IND500680912;   AGR:IND605429126;   CAS:126-17-0;   FooDB:FDB013944;   HMDB:HMDB0035282;   KEGG:C10822;   KNApSAcK:C00002264;   LINCS:LSM-6427
 xref_mesh: MESH:C012037
 xref: MetaCyc:CPD-13080;   PMID:21062107;   PMID:21496476;   PMID:21605251;   PMID:22399274;   PMID:22460423;   PMID:23954587;   PMID:24444441;   PMID:24922600;   PMID:26162798;   PMID:27462871;   PMID:28283413;   PMID:28552788;   PMID:28779706;   PMID:28803443;   PMID:28887171;   PMID:28919409;   PMID:30268504;   PMID:30614239;   PMID:30901960;   PMID:31234274;   PMID:31580372;   Wikipedia:Solasodine
 cyclic_relationship: is_conjugate_base_of CHEBI:145043

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solasodine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO solasodine results in decreased phosphorylation of AKT1 protein CTD PMID:28283413 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO solasodine results in decreased activity of BCHE protein CTD PMID:31152736 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bsg basigin decreases expression ISO solasodine results in decreased expression of BSG mRNA CTD PMID:28283413 NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:9,993,170...10,000,387 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO solasodine results in increased cleavage of and results in decreased expression of CASP3 protein CTD PMID:37121296 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO solasodine results in increased cleavage of and results in decreased expression of CASP7 protein CTD PMID:37121296 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO solasodine results in increased cleavage of and results in decreased expression of CASP9 protein CTD PMID:37121296 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions		 ISO solasodine results in increased expression of CDH1 protein
CLDN2 protein inhibits the reaction [solasodine results in increased expression of CDH1 protein]		 CTD PMID:37121296 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions		 ISO solasodine results in decreased expression of CDH2 mRNA; solasodine results in decreased expression of CDH2 protein
CLDN2 protein inhibits the reaction [solasodine results in decreased expression of CDH2 protein]		 CTD PMID:37121296 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cldn2 claudin 2 multiple interactions
decreases expression		 ISO acadesine promotes the reaction [solasodine results in decreased expression of CLDN2 protein]; CLDN2 protein inhibits the reaction [solasodine results in decreased expression of CDH2 protein]; CLDN2 protein inhibits the reaction [solasodine results in decreased expression of VIM protein]; CLDN2 protein inhibits the reaction [solasodine results in increased expression of CDH1 protein]
solasodine results in decreased expression of CLDN2 mRNA; solasodine results in decreased expression of CLDN2 protein		 CTD PMID:37121296 NCBI chr  X:108,248,383...108,258,847
Ensembl chr  X:103,459,780...103,474,838 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO solasodine results in decreased expression of GPX4 protein CTD PMID:37121296 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP solasodine inhibits the reaction [Ovalbumin results in increased secretion of IL1B protein] CTD PMID:36084726 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP solasodine inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] CTD PMID:36084726 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions EXP solasodine inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein] CTD PMID:36084726 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Mir21 microRNA 21 decreases expression ISO solasodine results in decreased expression of MIR21; solasodine results in decreased expression of MIR21 mRNA CTD PMID:28283413 PMID:37121296 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO solasodine results in decreased expression of MMP2 mRNA CTD PMID:28283413 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO solasodine results in decreased expression of MMP9 mRNA CTD PMID:28283413 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO solasodine results in increased cleavage of and results in decreased expression of PARP1 protein CTD PMID:37121296 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO solasodine results in increased phosphorylation of PRKAA1 protein CTD PMID:37121296 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs increases expression ISO solasodine results in increased expression of RECK mRNA CTD PMID:28283413 NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:58,102,981...58,169,502 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases localization ISO solasodine results in decreased localization of RELA protein CTD PMID:37121296 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO solasodine results in decreased expression of RHOA protein CTD PMID:37121296 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO solasodine results in decreased expression of SLC7A11 protein CTD PMID:37121296 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO solasodine results in decreased phosphorylation of STAT3 protein CTD PMID:37121296 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO solasodine results in increased expression of TIMP1 mRNA CTD PMID:28283413 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO solasodine results in increased expression of TIMP2 mRNA CTD PMID:28283413 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP solasodine inhibits the reaction [Ovalbumin results in increased secretion of TNF protein] CTD PMID:36084726 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vim vimentin decreases expression
multiple interactions		 ISO solasodine results in decreased expression of VIM mRNA; solasodine results in decreased expression of VIM protein
CLDN2 protein inhibits the reaction [solasodine results in decreased expression of VIM protein]		 CTD PMID:37121296 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        antispermatogenic agent 1166
          solasodine 27
            solasodine 3-beta-D-glucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    main group molecular entity 19824
                      s-block molecular entity 19658
                        hydrogen molecular entity 19640
                          hydrides 19145
                            inorganic hydride 18162
                              pnictogen hydride 18152
                                nitrogen hydride 18059
                                  azane 17869
                                    ammonia 17868
                                      organic amino compound 17868
                                        hemiaminal 728
                                          hemiaminal ether 651
                                            solasodine 27
                                              solasodine 3-beta-D-glucoside 0
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