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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cladribine
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Accession:CHEBI:567361 term browser browse the term
Definition:2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
Synonyms:exact_synonym: 2-chloro-2'-deoxyadenosine
 related_synonym: (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol;   2-CdA;   2-chloro-2'-deoxy-beta-adenosine;   2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine;   2-chloro-deoxyadenosine;   2-chlorodeoxyadenosine;   2ClAdo;   CldAdo;   Formula=C10H12ClN5O3;   InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1;   InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N;   SMILES=Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1;   cladribina;   cladribinum
 alt_id: CHEBI:31407;   CHEBI:568373
 xref: Beilstein:624220;   CAS:4291-63-8;   DrugBank:DB00242;   Drug_Central:667;   KEGG:D01370;   LINCS:LSM-5976
 xref_mesh: MESH:D017338
 xref: PMID:17526755;   PMID:18570408;   PMID:26024233;   Patent:EP173059;   Patent:US4760137;   Wikipedia:Cladribine


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cladribine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of BCL2 protein; BCL2 affects the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 inhibits the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]
Cladribine results in decreased expression of BCL2 protein		 CTD PMID:15516989 PMID:15582267 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of BIRC3 protein] CTD PMID:12948851 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO BCL2 inhibits the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP3 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP3 protein]; Cladribine results in increased cleavage of and results in increased activity of CASP3 protein
Cladribine results in increased activity of CASP3 protein		 CTD PMID:11672427 PMID:12948851 PMID:15516989 PMID:21679466 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 multiple interactions
increases activity		 ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP6 protein]
Cladribine results in increased activity of CASP6 protein		 CTD PMID:11672427 PMID:12948851 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP7 protein]
Cladribine results in increased activity of CASP7 protein		 CTD PMID:12948851 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases activity		 ISO [Valproic Acid co-treated with Cladribine] results in increased cleavage of CASP8 protein; BCL2 inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP8 protein]
Cladribine results in increased activity of CASP8 protein		 CTD PMID:11672427 PMID:12948851 PMID:15516989 PMID:19006566 PMID:21679466 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO BCL2 affects the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP9 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP9 protein]; Cladribine results in increased cleavage of and results in increased activity of CASP9 protein
Cladribine results in increased activity of CASP9 protein		 CTD PMID:11672427 PMID:12948851 PMID:15516989 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO Cladribine results in increased expression of CDKN1A mRNA
Cladribine promotes the reaction [resveratrol results in increased expression of CDKN1A mRNA]; resveratrol promotes the reaction [Cladribine results in increased expression of CDKN1A mRNA]		 CTD PMID:21801466 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Daxx death-domain associated protein multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of DAXX protein] CTD PMID:12948851 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased localization of DIABLO protein] CTD PMID:12948851 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
decreases expression		 ISO Cholecalciferol promotes the reaction [Cladribine results in decreased expression of DNMT1 mRNA]; Cladribine promotes the reaction [Cholecalciferol results in decreased expression of DNMT1 mRNA] CTD PMID:21801466 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Il4 interleukin 4 increases expression ISO Cladribine results in increased expression of IL4 mRNA CTD PMID:9751108 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Kmt2a lysine methyltransferase 2A increases response to substance ISO KMT2A gene mutant form results in increased susceptibility to Cladribine CTD PMID:14712291 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181 		JBrowse link
G Lmnb1 lamin B1 multiple interactions
increases cleavage		 ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of LMNB1 protein
Cladribine results in increased cleavage of LMNB1 protein		 CTD PMID:15582267 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502 		JBrowse link
G Nt5c1a 5'-nucleotidase, cytosolic IA decreases response to substance
multiple interactions		 ISO NT5C1A protein results in decreased susceptibility to Cladribine
NT5C1A protein results in decreased susceptibility to [Fluorouracil co-treated with Cladribine]		 CTD PMID:16362297 NCBI chr 5:135,473,107...135,494,400
Ensembl chr 5:135,473,231...135,499,338 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of PARP1 protein
Cladribine results in increased cleavage of PARP1 protein		 CTD PMID:15582267 PMID:21679466 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of PAWR protein] CTD PMID:12948851 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression
decreases methylation		 ISO Cholecalciferol promotes the reaction [Cladribine results in increased expression of PTEN mRNA]; Cholecalciferol promotes the reaction [Cladribine results in increased methylation of PTEN promoter]; Cladribine promotes the reaction [Cholecalciferol results in decreased methylation of PTEN promoter]; Cladribine promotes the reaction [Cholecalciferol results in increased expression of PTEN mRNA]; resveratrol promotes the reaction [Cladribine results in decreased methylation of PTEN promoter] CTD PMID:21801466 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Cladribine results in increased phosphorylation of STAT3 protein CTD PMID:21679466 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Cladribine results in increased expression of TNF protein CTD PMID:10540334 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Cladribine affects the activity of TP53 protein; Cladribine metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of XIAP protein] CTD PMID:12948851 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      biological role 19858
        immunomodulator 15064
          immunosuppressive agent 13942
            cladribine 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            heteroorganic entity 19502
                              organochalcogen compound 19264
                                organooxygen compound 19180
                                  carbohydrates and carbohydrate derivatives 15283
                                    carbohydrate 15304
                                      carbohydrate derivative 14317
                                        glycosyl compound 13080
                                          N-glycosyl compound 5878
                                            nucleoside 5735
                                              deoxyribonucleoside 2889
                                                2'-deoxyribonucleoside 2246
                                                  purine 2'-deoxyribonucleoside 34
                                                    cladribine 22
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